NT1 Neurotrophin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: NT1provided by FlyBase
Official Full Name: Neurotrophin 1provided by FlyBase
Primary source: FLYBASE:FBgn0261526
Locus tag: Dmel_CG42576
See related: AllianceGenome:FB:FBgn0261526
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18318; CG32242; CG32244; CG42576; CT30097; Dmel\CG42576; dNT1; DNT1; Spz; Spz-2; spz2; Spz2; SPZ2
Old locus tag: Dmel_CG32242; Dmel_CG32244
Summary: Enables Toll binding activity and growth factor activity. Involved in several processes, including Toll signaling pathway; nervous system development; and regulation of neuronal synaptic plasticity in response to neurotrophin. Located in extracellular space. Is expressed in several structures, including A1-7 ventral longitudinal muscle cell; adult brain; epithelium; midline glial cell; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4501652..4508433, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4501652..4508433, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila DNT1 mRNA levels are high during development but suppressed in adulthood.
Title: The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ.
Data suggest that Spz functions with neuron-type specificity at the muscle 4 NMJ, and DNT1 and DNT2 function together at the muscles 6,7 NMJ.
Title: Neuron-type specific functions of DNT1, DNT2 and Spz at the Drosophila neuromuscular junction.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables Toll binding	IBA Inferred from Biological aspect of Ancestor more info
enables Toll binding	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neuronal synaptic plasticity in response to neurotrophin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

Names: CG42576-PB; CG42576-PC; CG42576-PD; CG42576-PE; CG42576-PF; CG42576-PG; CG42576-PH; NT1-PB; NT1-PC; NT1-PD; NT1-PE; NT1-PF; NT1-PG; NT1-PH; drosophila Neurotrophin1; spatzle 2; spatzle2; spz2