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Conserved domains on  [gi|281365658|ref|NP_729009|]
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neurotrophin 1, isoform F [Drosophila melanogaster]

Protein Classification

spaetzle family protein( domain architecture ID 11240682)

spaetzle family protein similar to Drosophila melanogaster protein spaetzle, component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo; it binds to the Toll receptor and activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Spaetzle pfam16077
Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway ...
508-595 1.97e-39

Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway that establishes the dorsal-ventral pattern of the embryo. They form a cystine knot structure.


:

Pssm-ID: 465007  Cd Length: 93  Bit Score: 140.92  E-value: 1.97e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365658   508 MCQSVVRYARPQKAKSASGEWKYIVNTGQHTQTLRLEKCSNPVESCSYL---AQTYRSHCSQVYNYHRLLSWDKV-RGLH 583
Cdd:pfam16077    2 LCPSRERYIRPKRAKNTDGEWRVIVNTDEYTQGVRIETCSNPGQPCSFLdgfPPGYSSKCKQKYVYRRLLAIDDNgEGIF 81
                           90
                   ....*....|..
gi 281365658   584 VDIFKVPTCCSC 595
Cdd:pfam16077   82 TDSFKFPSCCSC 93
 
Name Accession Description Interval E-value
Spaetzle pfam16077
Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway ...
508-595 1.97e-39

Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway that establishes the dorsal-ventral pattern of the embryo. They form a cystine knot structure.


Pssm-ID: 465007  Cd Length: 93  Bit Score: 140.92  E-value: 1.97e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365658   508 MCQSVVRYARPQKAKSASGEWKYIVNTGQHTQTLRLEKCSNPVESCSYL---AQTYRSHCSQVYNYHRLLSWDKV-RGLH 583
Cdd:pfam16077    2 LCPSRERYIRPKRAKNTDGEWRVIVNTDEYTQGVRIETCSNPGQPCSFLdgfPPGYSSKCKQKYVYRRLLAIDDNgEGIF 81
                           90
                   ....*....|..
gi 281365658   584 VDIFKVPTCCSC 595
Cdd:pfam16077   82 TDSFKFPSCCSC 93
 
Name Accession Description Interval E-value
Spaetzle pfam16077
Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway ...
508-595 1.97e-39

Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway that establishes the dorsal-ventral pattern of the embryo. They form a cystine knot structure.


Pssm-ID: 465007  Cd Length: 93  Bit Score: 140.92  E-value: 1.97e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281365658   508 MCQSVVRYARPQKAKSASGEWKYIVNTGQHTQTLRLEKCSNPVESCSYL---AQTYRSHCSQVYNYHRLLSWDKV-RGLH 583
Cdd:pfam16077    2 LCPSRERYIRPKRAKNTDGEWRVIVNTDEYTQGVRIETCSNPGQPCSFLdgfPPGYSSKCKQKYVYRRLLAIDDNgEGIF 81
                           90
                   ....*....|..
gi 281365658   584 VDIFKVPTCCSC 595
Cdd:pfam16077   82 TDSFKFPSCCSC 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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