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CG3776 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37996, updated on 4-Jan-2025

Summary

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Official Symbol
CG3776provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035088
Locus tag
Dmel_CG3776
See related
AllianceGenome:FB:FBgn0035088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG3776; DmP29; EP(2)0835; Jhebp29; P29
Summary
Predicted to enable ribosome binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human MAIP1 (matrix AAA peptidase interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG3776 in Genome Data Viewer
Location:
60E11-60E11; 2-107 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24969678..24970855)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20857201..20858378)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene cGAS-like receptor 2 Neighboring gene Ribosomal protein L19 Neighboring gene Pherokine 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45252

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Localization of a Drosophila melanogaster homolog of the putative juvenile hormone esterase binding protein of Manduca sexta. Liu Z, et al. Insect Biochem Mol Biol, 2007 Feb. PMID 17244544
  2. Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance. Liu Z, et al. Gen Comp Endocrinol, 2008 Mar 1. PMID 18275960
  3. Potential ligands of DmP29, a putative juvenile hormone esterase binding protein of Drosophila melanogaster. Liu Z, et al. Insect Biochem Mol Biol, 2007 Aug. PMID 17628282
  4. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article
  5. A misexpression study examining dorsal thorax formation in Drosophila melanogaster. Peña-Rangel MT, et al. Genetics, 2002 Mar. PMID 11901120, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Underexpression of DmP29 resulted in reduced longevity, increased fecundity and reduced titers of pupal juvenile hormone esterase.
    Title: Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance.
  2. Recombinant DmP29 was shown by ligand blot and co-immunoprecipitation analyses to bind recombinant juvenile hormone esterase as well as to larval serum proteins (LSP).
    Title: Potential ligands of DmP29, a putative juvenile hormone esterase binding protein of Drosophila melanogaster.
  3. homolog of P29, a putative juvenile hormone esterase binding protein isolated from the tobacco hornworm Manduca sexta
    Title: Localization of a Drosophila melanogaster homolog of the putative juvenile hormone esterase binding protein of Manduca sexta.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein insertion into mitochondrial inner membrane from matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG3776-PA
CG3776-PB
CG3776-PC
drosophila P29
juvenile hormone esterase binding protein 29

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24969678..24970855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299939.1 → NP_001286868.1  uncharacterized protein Dmel_CG3776, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0X3
    Conserved Domains (1) summary
    cl09208
    Location:101 → 144
    Tim44; Tim44-like domain

  2. NM_138145.3 → NP_611989.1  uncharacterized protein Dmel_CG3776, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611989.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W0X3
    Related
    FBpp0072302
    Conserved Domains (1) summary
    cl09208
    Location:101 → 144
    Tim44; Tim44-like domain

  3. NM_001299940.1 → NP_001286869.1  uncharacterized protein Dmel_CG3776, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHN1
    Conserved Domains (1) summary
    cl09208
    Location:101 → 144
    Tim44; Tim44-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHN1 A0A0B4LHN1
Q9W0X3 Q9W0X3

Gene LinkOut

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