uncharacterized protein Dmel_CG3776, isoform C [Drosophila melanogaster]
Protein Classification
Tim44 domain-containing protein( domain architecture ID 5133)
Tim44 domain-containing protein similar to mitochondrial 39S ribosomal protein L45 and to mitochondrial import inner membrane translocase subunit Tim44, an essential component of the eukaryotic PAM complex which is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Tim44 super family | cl09208 | Tim44-like domain; Tim44 is an essential component of the machinery that mediates the ... |
101-166 | 9.37e-03 | ||
Tim44-like domain; Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane. Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region. This family includes the C-terminal region of Tim44 that has been shown to form a stable proteolytic fragment in yeast. This region is also found in a set of smaller bacterial proteins. The molecular function of the bacterial members of this family is unknown but transport seems likely. The crystal structure of the C terminal of Tim44 has revealed a large hydrophobic pocket which might play an important role in interacting with the acyl chains of lipid molecules in the mitochondrial membrane. The actual alignment was detected with superfamily member pfam04280: Pssm-ID: 447694 Cd Length: 145 Bit Score: 35.29 E-value: 9.37e-03
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| Name | Accession | Description | Interval | E-value | ||
| Tim44 | pfam04280 | Tim44-like domain; Tim44 is an essential component of the machinery that mediates the ... |
101-166 | 9.37e-03 | ||
Tim44-like domain; Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane. Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region. This family includes the C-terminal region of Tim44 that has been shown to form a stable proteolytic fragment in yeast. This region is also found in a set of smaller bacterial proteins. The molecular function of the bacterial members of this family is unknown but transport seems likely. The crystal structure of the C terminal of Tim44 has revealed a large hydrophobic pocket which might play an important role in interacting with the acyl chains of lipid molecules in the mitochondrial membrane. Pssm-ID: 427835 Cd Length: 145 Bit Score: 35.29 E-value: 9.37e-03
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| Tim44 | COG4395 | Predicted lipid-binding transport protein, Tim44 family [Lipid transport and metabolism]; |
101-151 | 9.60e-03 | ||
Predicted lipid-binding transport protein, Tim44 family [Lipid transport and metabolism]; Pssm-ID: 443521 Cd Length: 186 Bit Score: 35.65 E-value: 9.60e-03
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| Name | Accession | Description | Interval | E-value | ||
| Tim44 | pfam04280 | Tim44-like domain; Tim44 is an essential component of the machinery that mediates the ... |
101-166 | 9.37e-03 | ||
Tim44-like domain; Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane. Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region. This family includes the C-terminal region of Tim44 that has been shown to form a stable proteolytic fragment in yeast. This region is also found in a set of smaller bacterial proteins. The molecular function of the bacterial members of this family is unknown but transport seems likely. The crystal structure of the C terminal of Tim44 has revealed a large hydrophobic pocket which might play an important role in interacting with the acyl chains of lipid molecules in the mitochondrial membrane. Pssm-ID: 427835 Cd Length: 145 Bit Score: 35.29 E-value: 9.37e-03
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| Tim44 | COG4395 | Predicted lipid-binding transport protein, Tim44 family [Lipid transport and metabolism]; |
101-151 | 9.60e-03 | ||
Predicted lipid-binding transport protein, Tim44 family [Lipid transport and metabolism]; Pssm-ID: 443521 Cd Length: 186 Bit Score: 35.65 E-value: 9.60e-03
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