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MED23 Mediator complex subunit 23 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37639, updated on 9-Dec-2024

Summary

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Official Symbol
MED23provided by FlyBase
Official Full Name
Mediator complex subunit 23provided by FlyBase
Primary source
FLYBASE:FBgn0034795
Locus tag
Dmel_CG3695
See related
AllianceGenome:FB:FBgn0034795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3695; Dmel\CG3695; dSUR2; dTRAP150beta; Gal11/SUR2; Med23; Trap150; Trap150beta
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex and transcription regulator complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Orthologous to human MED23 (mediator complex subunit 23). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See MED23 in Genome Data Viewer
Location:
59B4-59B4; 2-101 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22888928..22894425)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18776451..18781948)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene YME1 like ATPase Neighboring gene asrij Neighboring gene GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase Neighboring gene uncharacterized protein Neighboring gene nahoda

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Chu Y, et al. Cell Res, 2014 Oct. PMID 25223702, Free PMC Article
  2. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Boube M, et al. Cell, 2002 Jul 26. PMID 12150923
  3. Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes. Oh H, et al. Cell Rep, 2013 Feb 21. PMID 23395637, Free PMC Article
  4. Identification of potential pathways and biomarkers linked to progression in ALS. Huber RG, et al. Ann Clin Transl Neurol, 2023 Feb. PMID 36533811, Free PMC Article
  5. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Boube M, et al. Genes Dev, 2000 Nov 15. PMID 11090137, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mediator complex subunit 23
Names
CG3695-PA
MED23-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22888928..22894425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137891.3 → NP_611735.1  mediator complex subunit 23 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611735.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2RVE3, Q9W1X7
    Related
    FBpp0071814
    Conserved Domains (1) summary
    pfam11573
    Location:1 → 1299
    Med23; Mediator complex subunit 23
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1X7.1 Q9W1X7

Gene LinkOut

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Chemical Information
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