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Conserved domains on  [gi|19922780|ref|NP_611735|]
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mediator complex subunit 23 [Drosophila melanogaster]

Protein Classification

Med23 domain-containing protein( domain architecture ID 10569018)

Med23 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1299 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


:

Pssm-ID: 463299  Cd Length: 1301  Bit Score: 1803.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780      1 METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLLRAAG-ASGYHIKVLM 79
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHvAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780     80 AALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVDYKGVREIMKVCRDKAQWFPLNVNVTYMPQL 159
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    160 LAVEDILRFIFDRNNCLLPAYFIANEIMRPFPY-----HWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADH 234
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDakmwpHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGYADH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    235 MMNSWRLDHNTLKFNFKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVNLIVQAMEMTE 314
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHKQRCKALEEQLVELMICAMERSE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    315 ANDAtagsgfnssDEQITpyEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQLMWILLQFISGSIQKN 394
Cdd:pfam11573  321 TEPE---------DEPIT--HWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKN 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    395 PITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKARVENMNITRPLPIALKNHYDFLQHLVTANTM 474
Cdd:pfam11573  390 PLSDFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHLVLNNDS 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    475 MNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLDALNGTSKSPNGGQI---PAVTFSVTVLDSLTVHSKMSLIHSFVTQM 551
Cdd:pfam11573  470 PNLAMGSDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKSRSPGCNapgPTTPLSMEFLDSLTVHSKMSLIHSIVTHV 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    552 LKQAQSKGQV-PAAALLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLL 630
Cdd:pfam11573  550 IKFAQSKSSVaLAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHL 629

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    631 HSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVaSNESEELNRVLILTLARSMHVHGGGDEMQ 710
Cdd:pfam11573  630 HSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLV-SQESEELNRALILTLARAIHITGTGTDSE 708

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    711 GWCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQLKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLF 790
Cdd:pfam11573  709 SWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLF 788

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    791 LCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDYLVAEVASSSDGRDFiHKCVDTINNMIWKFNVVTIDRVVLC 870
Cdd:pfam11573  789 LCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHV-NKCADALNDMIWKYNIVTIDRLVLC 867

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    871 LALRTHEGNEAQVCFLIIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDE-----SASQIPL 945
Cdd:pfam11573  868 LALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGvaeydSSSNPYL 947

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    946 PVYFSNVCLRFLPVLDVVVHRFIELtiTNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYERILRDRPALKKKLVGAI 1025
Cdd:pfam11573  948 PTYFGNVCLRFLPVLDIVIHRALEL--PPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAI 1025

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780   1026 TSAFSEIRPPNWSVSEPYKVYLQSQ--DSLWTPELSYYMSLIRRLADTISGKNV--FYSTDWRFNEFPNAPTHALYVTCV 1101
Cdd:pfam11573 1026 IGSLKDCRPPGWALTEAYEKYHQKSsdEQLIWLPEDYYMKLIDRMVDTMDGKTPppFPAKDWRFNEFPNPGAHALYVTCV 1105

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780   1102 ELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWTYRFNAFELF 1181
Cdd:pfam11573 1106 ELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYPCSPFELF 1185

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780   1182 NFKTVREAMLEKTYAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGIA 1261
Cdd:pfam11573 1186 NFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDIT 1265

                         1290      1300      1310
                   ....*....|....*....|....*....|....*...
gi 19922780   1262 VLLYEILEIVDKHHgpKPLQYMDQICDFLYHIKYIHVG 1299
Cdd:pfam11573 1266 KLLYELLEQVDKEG--VELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1299 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 1803.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780      1 METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLLRAAG-ASGYHIKVLM 79
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHvAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780     80 AALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVDYKGVREIMKVCRDKAQWFPLNVNVTYMPQL 159
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    160 LAVEDILRFIFDRNNCLLPAYFIANEIMRPFPY-----HWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADH 234
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDakmwpHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGYADH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    235 MMNSWRLDHNTLKFNFKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVNLIVQAMEMTE 314
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHKQRCKALEEQLVELMICAMERSE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    315 ANDAtagsgfnssDEQITpyEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQLMWILLQFISGSIQKN 394
Cdd:pfam11573  321 TEPE---------DEPIT--HWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKN 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    395 PITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKARVENMNITRPLPIALKNHYDFLQHLVTANTM 474
Cdd:pfam11573  390 PLSDFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHLVLNNDS 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    475 MNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLDALNGTSKSPNGGQI---PAVTFSVTVLDSLTVHSKMSLIHSFVTQM 551
Cdd:pfam11573  470 PNLAMGSDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKSRSPGCNapgPTTPLSMEFLDSLTVHSKMSLIHSIVTHV 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    552 LKQAQSKGQV-PAAALLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLL 630
Cdd:pfam11573  550 IKFAQSKSSVaLAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHL 629

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    631 HSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVaSNESEELNRVLILTLARSMHVHGGGDEMQ 710
Cdd:pfam11573  630 HSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLV-SQESEELNRALILTLARAIHITGTGTDSE 708

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    711 GWCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQLKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLF 790
Cdd:pfam11573  709 SWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLF 788

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    791 LCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDYLVAEVASSSDGRDFiHKCVDTINNMIWKFNVVTIDRVVLC 870
Cdd:pfam11573  789 LCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHV-NKCADALNDMIWKYNIVTIDRLVLC 867

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    871 LALRTHEGNEAQVCFLIIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDE-----SASQIPL 945
Cdd:pfam11573  868 LALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGvaeydSSSNPYL 947

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    946 PVYFSNVCLRFLPVLDVVVHRFIELtiTNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYERILRDRPALKKKLVGAI 1025
Cdd:pfam11573  948 PTYFGNVCLRFLPVLDIVIHRALEL--PPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAI 1025

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780   1026 TSAFSEIRPPNWSVSEPYKVYLQSQ--DSLWTPELSYYMSLIRRLADTISGKNV--FYSTDWRFNEFPNAPTHALYVTCV 1101
Cdd:pfam11573 1026 IGSLKDCRPPGWALTEAYEKYHQKSsdEQLIWLPEDYYMKLIDRMVDTMDGKTPppFPAKDWRFNEFPNPGAHALYVTCV 1105

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780   1102 ELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWTYRFNAFELF 1181
Cdd:pfam11573 1106 ELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYPCSPFELF 1185

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780   1182 NFKTVREAMLEKTYAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGIA 1261
Cdd:pfam11573 1186 NFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDIT 1265

                         1290      1300      1310
                   ....*....|....*....|....*....|....*...
gi 19922780   1262 VLLYEILEIVDKHHgpKPLQYMDQICDFLYHIKYIHVG 1299
Cdd:pfam11573 1266 KLLYELLEQVDKEG--VELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 1-1299 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 1803.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780      1 METQVIDTVNEFLKVDSLDEAFVSVIVFKPNTEQERATRFANDLVTAFGNVAQENREQVLRLYLLRAAG-ASGYHIKVLM 79
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHvAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780     80 AALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIVQVDYKGVREIMKVCRDKAQWFPLNVNVTYMPQL 159
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    160 LAVEDILRFIFDRNNCLLPAYFIANEIMRPFPY-----HWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADH 234
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDakmwpHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGYADH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    235 MMNSWRLDHNTLKFNFKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVNLIVQAMEMTE 314
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHKQRCKALEEQLVELMICAMERSE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    315 ANDAtagsgfnssDEQITpyEWMWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQLMWILLQFISGSIQKN 394
Cdd:pfam11573  321 TEPE---------DEPIT--HWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKN 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    395 PITNFLPVFRLFDLLYPELEPLKLPDINKSSMVRHMAPICVWIHLMKKARVENMNITRPLPIALKNHYDFLQHLVTANTM 474
Cdd:pfam11573  390 PLSDFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHLVLNNDS 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    475 MNMTLGNDFRIILICNAYSTNQEYFGRPMGLLLDALNGTSKSPNGGQI---PAVTFSVTVLDSLTVHSKMSLIHSFVTQM 551
Cdd:pfam11573  470 PNLAMGSDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKSRSPGCNapgPTTPLSMEFLDSLTVHSKMSLIHSIVTHV 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    552 LKQAQSKGQV-PAAALLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLL 630
Cdd:pfam11573  550 IKFAQSKSSVaLAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSHL 629

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    631 HSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNDKSPGAVaSNESEELNRVLILTLARSMHVHGGGDEMQ 710
Cdd:pfam11573  630 HSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLV-SQESEELNRALILTLARAIHITGTGTDSE 708

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    711 GWCKDFLSNIIQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQLKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLF 790
Cdd:pfam11573  709 SWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGTPPLF 788

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    791 LCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDYLVAEVASSSDGRDFiHKCVDTINNMIWKFNVVTIDRVVLC 870
Cdd:pfam11573  789 LCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHV-NKCADALNDMIWKYNIVTIDRLVLC 867

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    871 LALRTHEGNEAQVCFLIIQLLLLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDE-----SASQIPL 945
Cdd:pfam11573  868 LALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGvaeydSSSNPYL 947

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780    946 PVYFSNVCLRFLPVLDVVVHRFIELtiTNVHQILGFILDHLSILYKFHDRPITYLYNTLHYYERILRDRPALKKKLVGAI 1025
Cdd:pfam11573  948 PTYFGNVCLRFLPVLDIVIHRALEL--PPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRKLVSAI 1025

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780   1026 TSAFSEIRPPNWSVSEPYKVYLQSQ--DSLWTPELSYYMSLIRRLADTISGKNV--FYSTDWRFNEFPNAPTHALYVTCV 1101
Cdd:pfam11573 1026 IGSLKDCRPPGWALTEAYEKYHQKSsdEQLIWLPEDYYMKLIDRMVDTMDGKTPppFPAKDWRFNEFPNPGAHALYVTCV 1105

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780   1102 ELLGLPVAPPLVASNLIDVIVSGYAVIPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWTYRFNAFELF 1181
Cdd:pfam11573 1106 ELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYPCSPFELF 1185

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922780   1182 NFKTVREAMLEKTYAVVLAVAHSVFHHMGAFKLAAMTRYLKEKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGIA 1261
Cdd:pfam11573 1186 NFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERERGVLDIT 1265

                         1290      1300      1310
                   ....*....|....*....|....*....|....*...
gi 19922780   1262 VLLYEILEIVDKHHgpKPLQYMDQICDFLYHIKYIHVG 1299
Cdd:pfam11573 1266 KLLYELLEQVDKEG--VELRYMDPICDLLYHIKYMFVG 1301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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