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MFS16 Major Facilitator Superfamily Transporter 16 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37427, updated on 4-Jan-2025

Summary

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Official Symbol
MFS16provided by FlyBase
Official Full Name
Major Facilitator Superfamily Transporter 16provided by FlyBase
Primary source
FLYBASE:FBgn0034611
Locus tag
Dmel_CG10069
See related
AllianceGenome:FB:FBgn0034611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10069; Dmel\CG10069
Summary
Predicted to enable glucose 6-phosphate:phosphate antiporter activity. Predicted to be involved in gluconeogenesis and glucose-6-phosphate transport. Predicted to be located in endoplasmic reticulum membrane. Is expressed in organism. Orthologous to human SLC37A1 (solute carrier family 37 member 1) and SLC37A2 (solute carrier family 37 member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See MFS16 in Genome Data Viewer
Location:
57D7-57D7; 2-94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21282298..21285679)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17169803..17173184)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rad, Gem/Kir family member 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SAGA-associated factor 29kDa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
  2. Roles of major facilitator superfamily transporters in phosphate response in Drosophila. Bergwitz C, et al. PLoS One, 2012. PMID 22359624, Free PMC Article
  3. The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death. Velentzas PD, et al. Dev Cell, 2018 Nov 5. PMID 30318245, Free PMC Article
  4. Glial solute carrier transporters in Drosophila and mice. Featherstone DE. Glia, 2011 Sep. PMID 21732427
  5. A phylogenetic analysis between humans and D. melanogaster: A repertoire of solute carriers in humans and flies. Ceder MM, et al. Gene, 2022 Jan 30. PMID 34673204

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glucose 6-phosphate:phosphate antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose 6-phosphate:phosphate antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose-6-phosphate transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major facilitator superfamily transporter 16
Names
CG10069-PA
CG10069-PB
CG10069-PC
CG10069-PD
MFS16-PA
MFS16-PB
MFS16-PC
MFS16-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21282298..21285679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166434.2 → NP_726048.1  major facilitator superfamily transporter 16, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726048.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MLW5
    Related
    FBpp0071516
    Conserved Domains (2) summary
    cd06174
    Location:139 → 549
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:84 → 545
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  2. NM_137726.3 → NP_611570.3  major facilitator superfamily transporter 16, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611570.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960B6, Q9W2I6
    Related
    FBpp0071515
    Conserved Domains (2) summary
    cd06174
    Location:101 → 511
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:46 → 507
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  3. NM_166435.2 → NP_726049.1  major facilitator superfamily transporter 16, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726049.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960B6, Q9W2I6
    Related
    FBpp0071517
    Conserved Domains (2) summary
    cd06174
    Location:101 → 511
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:46 → 507
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  4. NM_001299742.1 → NP_001286671.1  major facilitator superfamily transporter 16, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286671.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960B6, Q9W2I6
    Conserved Domains (2) summary
    cd06174
    Location:101 → 511
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:46 → 507
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MLW5 Q8MLW5
Q9W2I6 Q9W2I6

Gene LinkOut

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