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Oseg6 Outer segment 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37245, updated on 9-Dec-2024

Summary

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Official Symbol
Oseg6provided by FlyBase
Official Full Name
Outer segment 6provided by FlyBase
Primary source
FLYBASE:FBgn0034452
Locus tag
Dmel_CG11237
See related
AllianceGenome:FB:FBgn0034452
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11237; Dmel\CG11237; IFT144; OSEG; oseg6; OSEG6; Wdr19; WDR19
Summary
Involved in cilium assembly. Located in non-motile cilium. Is expressed in chordotonal neurons; eo neurons; and larval antenno-maxillary sensory complex. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; asphyxiating thoracic dystrophy 5; cranioectodermal dysplasia 4; and nephronophthisis 13. Orthologous to human WDR19 (WD repeat domain 19). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Oseg6 in Genome Data Viewer
Location:
56D12-56D13; 2-89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19487046..19491846, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15374551..15379351, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene meiotic W68 Neighboring gene par-1 Neighboring gene Tubulin-binding cofactor B Neighboring gene Rab escort protein Neighboring gene hippo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Wg/Wnt-signaling-induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interference with the IFT-A complex. Vuong LT, et al. Cell Rep, 2024 Jun 25. PMID 38870008, Free PMC Article
  2. Novel tools to unravel molecular mechanisms in cilia-related disorders. Fliegauf M, et al. Trends Genet, 2006 May. PMID 16564109
  3. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Jékely G, et al. Bioessays, 2006 Feb. PMID 16435301
  4. Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo. Gogia N, et al. Neurobiol Dis, 2020 Jul. PMID 32199908, Free PMC Article
  5. Drosophila Ovarian Germline Stem Cell Cytocensor Projections Dynamically Receive and Attenuate BMP Signaling. Wilcockson SG, et al. Dev Cell, 2019 Aug 5. PMID 31178401, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary retrograde transport IEA
Inferred from Electronic Annotation
more info
  
involved_in non-motile cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle A ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
outer segment 6
Names
CG11237-PA
Oseg6-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19487046..19491846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137582.3 → NP_611426.1  outer segment 6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611426.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBM3
    Related
    FBpp0085689
    Conserved Domains (4) summary
    COG2319
    Location:2 → 370
    WD40; WD40 repeat [General function prediction only]
    pfam15911
    Location:515 → 571
    WD40_3; WD domain, G-beta repeat
    sd00039
    Location:56 → 97
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:53 → 344
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBM3 A1ZBM3
Q8MZ45 Q8MZ45

Gene LinkOut

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