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Conserved domains on  [gi|24655809|ref|NP_611426|]
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outer segment 6 [Drosophila melanogaster]

Protein Classification

WD40 and WD40_3 domain-containing protein( domain architecture ID 11456978)

WD40 and WD40_3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
515-571 2.17e-23

WD domain, G-beta repeat;


:

Pssm-ID: 464937  Cd Length: 57  Bit Score: 94.19  E-value: 2.17e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24655809    515 CTIYRHSMGIRQLFMDIEGTKVIFIDDHSQGYVFLPVVEEALLIPDIPKQCLGCLWD 571
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
WD40 COG2319
WD40 repeat [General function prediction only];
26-344 8.25e-19

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 8.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   26 ALLATTGTDGSVALYNRQGQLVQRIIL--SGLCSGFAWDQEGDLLgiITSGSPN-ITLWDYNSQEKISVETGLRDPLTCI 102
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTghTGAVRSVAFSPDGKTL--ASGSADGtVRLWDLATGKLLRTLTGHSGAVTSV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  103 LWSKQQQLLAVGTGRGNLAIYNHSSGKRPTPVLGkHSKRITCGAWSAQ-NLLALGSEDKSFSLSneDGDTVRVVQLRDAP 181
Cdd:COG2319  169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDgKLLASGSADGTVRLW--DLATGKLLRTLTGH 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  182 TDMYFAeMA---NDERIA---GDnaismiigkRTLFLYYLPEPENPTELGFQSryGSLMQHKWFGDGYILLGFSNGHVVA 255
Cdd:COG2319  246 SGSVRS-VAfspDGRLLAsgsAD---------GTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVR 313

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  256 I---SThpkdvGQELWQVKNHKDSLTGLAYCPTLDIVASCGDD-SIKIHsitNLQETERIITVPDHAG-VQMIDWSPDGQ 330
Cdd:COG2319  314 LwdlAT-----GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDgTVRLW---DLATGELLRTLTGHTGaVTSVAFSPDGR 385

                        330
                 ....*....|....
gi 24655809  331 LLAVTTNHGTVYIY 344
Cdd:COG2319  386 TLASGSADGTVRLW 399
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 731-1024 3.60e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  731 QYDQAKEHMLKGV-------YTRAAL-DLCRDLLQWDQALLL---AHKNDPQEVPY---IAREYAQQlefnGNYTDALYH 796
Cdd:COG2956   23 QPDKAIDLLEEALeldpetvEAHLALgNLYRRRGEYDRAIRIhqkLLERDPDRAEAlleLAQDYLKA----GLLDRAEEL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  797 YEKgykedlinsketetdaLMDSSPEYEEHVRLckmgIARTSIRAGDFRRGIQYAVELEDQQLlfDCAELLatvghlTEA 876
Cdd:COG2956   99 LEK----------------LLELDPDDAEALRL----LAEIYEQEGDWEKAIEVLERLLKLGP--ENAHAY------CEL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  877 AGLYERGGFYDEAcghyiaLKMWNKANNILPKvkSTKLHAAYAKAKENDGHYEEAIRSYRIAGDLDAcvriyldhlcdph 956
Cdd:COG2956  151 AELYLEQGDYDEA------IEALEKALKLDPD--CARALLLLAELYLEQGDYEEAIAALERALEQDP------------- 209

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24655809  957 aaseivlesRSMDSAKLLAKFYQKIGDVEQALQFLvicgcvEEAFALAQRHNKLRRHGELLERYENAK 1024
Cdd:COG2956  210 ---------DYLPALPRLAELYEKLGDPEEALELL------RKALELDPSDDLLLALADLLERKEGLE 262
 
Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
515-571 2.17e-23

WD domain, G-beta repeat;


Pssm-ID: 464937  Cd Length: 57  Bit Score: 94.19  E-value: 2.17e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24655809    515 CTIYRHSMGIRQLFMDIEGTKVIFIDDHSQGYVFLPVVEEALLIPDIPKQCLGCLWD 571
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
WD40 COG2319
WD40 repeat [General function prediction only];
26-344 8.25e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 8.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   26 ALLATTGTDGSVALYNRQGQLVQRIIL--SGLCSGFAWDQEGDLLgiITSGSPN-ITLWDYNSQEKISVETGLRDPLTCI 102
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTghTGAVRSVAFSPDGKTL--ASGSADGtVRLWDLATGKLLRTLTGHSGAVTSV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  103 LWSKQQQLLAVGTGRGNLAIYNHSSGKRPTPVLGkHSKRITCGAWSAQ-NLLALGSEDKSFSLSneDGDTVRVVQLRDAP 181
Cdd:COG2319  169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDgKLLASGSADGTVRLW--DLATGKLLRTLTGH 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  182 TDMYFAeMA---NDERIA---GDnaismiigkRTLFLYYLPEPENPTELGFQSryGSLMQHKWFGDGYILLGFSNGHVVA 255
Cdd:COG2319  246 SGSVRS-VAfspDGRLLAsgsAD---------GTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVR 313

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  256 I---SThpkdvGQELWQVKNHKDSLTGLAYCPTLDIVASCGDD-SIKIHsitNLQETERIITVPDHAG-VQMIDWSPDGQ 330
Cdd:COG2319  314 LwdlAT-----GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDgTVRLW---DLATGELLRTLTGHTGaVTSVAFSPDGR 385

                        330
                 ....*....|....
gi 24655809  331 LLAVTTNHGTVYIY 344
Cdd:COG2319  386 TLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-344 8.80e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 8.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   53 SGLCSGFAWDQEGDLLGiitSGSPN--ITLWDYNSQEKISVETGLRDPLTCILWSKQQQLLAVGTGRGNLAIYNHSSGKR 130
Cdd:cd00200    9 TGGVTCVAFSPDGKLLA---TGSGDgtIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  131 PTPVLGkHSKRITCGAWSAQN-LLALGSEDKSFSL-SNEDGDTVRVVQLRDAPtdmyfaemANDERIAGDNaiSMIIG-- 206
Cdd:cd00200   86 VRTLTG-HTSYVSSVAFSPDGrILSSSSRDKTIKVwDVETGKCLTTLRGHTDW--------VNSVAFSPDG--TFVASss 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  207 -KRTLFLYylpepenptELGFQSRYGSLMQHK-------WFGDGY-ILLGFSNGHVvaisthpK----DVGQELWQVKNH 273
Cdd:cd00200  155 qDGTIKLW---------DLRTGKCVATLTGHTgevnsvaFSPDGEkLLSSSSDGTI-------KlwdlSTGKCLGTLRGH 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24655809  274 KDSLTGLAYCPTLDIVASCGDD-SIKIHsitNLQETERIITVPDH-AGVQMIDWSPDGQLLAVTTNHGTVYIY 344
Cdd:cd00200  219 ENGVNSVAFSPDGYLLASGSEDgTIRVW---DLRTGECVQTLSGHtNSVTSLAWSPDGKRLASGSADGTIRIW 288
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 731-1024 3.60e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  731 QYDQAKEHMLKGV-------YTRAAL-DLCRDLLQWDQALLL---AHKNDPQEVPY---IAREYAQQlefnGNYTDALYH 796
Cdd:COG2956   23 QPDKAIDLLEEALeldpetvEAHLALgNLYRRRGEYDRAIRIhqkLLERDPDRAEAlleLAQDYLKA----GLLDRAEEL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  797 YEKgykedlinsketetdaLMDSSPEYEEHVRLckmgIARTSIRAGDFRRGIQYAVELEDQQLlfDCAELLatvghlTEA 876
Cdd:COG2956   99 LEK----------------LLELDPDDAEALRL----LAEIYEQEGDWEKAIEVLERLLKLGP--ENAHAY------CEL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  877 AGLYERGGFYDEAcghyiaLKMWNKANNILPKvkSTKLHAAYAKAKENDGHYEEAIRSYRIAGDLDAcvriyldhlcdph 956
Cdd:COG2956  151 AELYLEQGDYDEA------IEALEKALKLDPD--CARALLLLAELYLEQGDYEEAIAALERALEQDP------------- 209

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24655809  957 aaseivlesRSMDSAKLLAKFYQKIGDVEQALQFLvicgcvEEAFALAQRHNKLRRHGELLERYENAK 1024
Cdd:COG2956  210 ---------DYLPALPRLAELYEKLGDPEEALELL------RKALELDPSDDLLLALADLLERKEGLE 262
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 280-362 4.34e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.42  E-value: 4.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809    280 LAYCPTLDIVA--SCgDDSIKIHSItNLQeteRIITVPDHAG---VQMIDWSPDGQLLAVTTNHGTVYI---YVTKLPHL 351
Cdd:pfam12894    1 MSWCPTMDLIAlaTE-DGELLLHRL-NWQ---RVWTLSPDKEdleVTSLAWRPDGKLLAVGYSDGTVRLldaENGKIVHH 75

                           90
                   ....*....|.
gi 24655809    352 FAVSAPRIVLL 362
Cdd:pfam12894   76 FSAGSDLITCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 264-301 7.23e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 7.23e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 24655809     264 GQELWQVKNHKDSLTGLAYCPTLDIVASCGDD-SIKIHS 301
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLWD 40
 
Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
515-571 2.17e-23

WD domain, G-beta repeat;


Pssm-ID: 464937  Cd Length: 57  Bit Score: 94.19  E-value: 2.17e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 24655809    515 CTIYRHSMGIRQLFMDIEGTKVIFIDDHSQGYVFLPVVEEALLIPDIPKQCLGCLWD 571
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
WD40 COG2319
WD40 repeat [General function prediction only];
26-344 8.25e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 8.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   26 ALLATTGTDGSVALYNRQGQLVQRIIL--SGLCSGFAWDQEGDLLgiITSGSPN-ITLWDYNSQEKISVETGLRDPLTCI 102
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTghTGAVRSVAFSPDGKTL--ASGSADGtVRLWDLATGKLLRTLTGHSGAVTSV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  103 LWSKQQQLLAVGTGRGNLAIYNHSSGKRPTPVLGkHSKRITCGAWSAQ-NLLALGSEDKSFSLSneDGDTVRVVQLRDAP 181
Cdd:COG2319  169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDgKLLASGSADGTVRLW--DLATGKLLRTLTGH 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  182 TDMYFAeMA---NDERIA---GDnaismiigkRTLFLYYLPEPENPTELGFQSryGSLMQHKWFGDGYILLGFSNGHVVA 255
Cdd:COG2319  246 SGSVRS-VAfspDGRLLAsgsAD---------GTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVR 313

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  256 I---SThpkdvGQELWQVKNHKDSLTGLAYCPTLDIVASCGDD-SIKIHsitNLQETERIITVPDHAG-VQMIDWSPDGQ 330
Cdd:COG2319  314 LwdlAT-----GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDgTVRLW---DLATGELLRTLTGHTGaVTSVAFSPDGR 385

                        330
                 ....*....|....
gi 24655809  331 LLAVTTNHGTVYIY 344
Cdd:COG2319  386 TLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
13-344 1.46e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   13 PHGIGDVYFIWQKALLATTGTDGSVALYNRQGQLVQRIILSGLCSGFAWDQEGDLLGIITSGSPN-ITLWDYNSQEKISV 91
Cdd:COG2319   36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGtVRLWDLATGLLLRT 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   92 ETGLRDPLTCILWSKQQQLLAVGTGRGNLAIYNHSSGKRPTPVLGkHSKRITCGAWSAQ-NLLALGSEDKSFSL-SNEDG 169
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDgKLLASGSDDGTVRLwDLATG 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  170 DTVRVVQLRDAP-TDMYFAemANDERIA---GDNaismiigkrTLFLYYLPEPENPTEL-GFQSRYGSLmqhKWFGDGYI 244
Cdd:COG2319  195 KLLRTLTGHTGAvRSVAFS--PDGKLLAsgsADG---------TVRLWDLATGKLLRTLtGHSGSVRSV---AFSPDGRL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  245 LLGFSNGHVVAI---SThpkdvGQELWQVKNHKDSLTGLAYCPTLDIVASCGDD-SIKihsITNLQETERIITVPDHAG- 319
Cdd:COG2319  261 LASGSADGTVRLwdlAT-----GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDgTVR---LWDLATGKLLRTLTGHTGa 332

                        330       340
                 ....*....|....*....|....*
gi 24655809  320 VQMIDWSPDGQLLAVTTNHGTVYIY 344
Cdd:COG2319  333 VRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-344 8.80e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 8.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   53 SGLCSGFAWDQEGDLLGiitSGSPN--ITLWDYNSQEKISVETGLRDPLTCILWSKQQQLLAVGTGRGNLAIYNHSSGKR 130
Cdd:cd00200    9 TGGVTCVAFSPDGKLLA---TGSGDgtIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  131 PTPVLGkHSKRITCGAWSAQN-LLALGSEDKSFSL-SNEDGDTVRVVQLRDAPtdmyfaemANDERIAGDNaiSMIIG-- 206
Cdd:cd00200   86 VRTLTG-HTSYVSSVAFSPDGrILSSSSRDKTIKVwDVETGKCLTTLRGHTDW--------VNSVAFSPDG--TFVASss 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  207 -KRTLFLYylpepenptELGFQSRYGSLMQHK-------WFGDGY-ILLGFSNGHVvaisthpK----DVGQELWQVKNH 273
Cdd:cd00200  155 qDGTIKLW---------DLRTGKCVATLTGHTgevnsvaFSPDGEkLLSSSSDGTI-------KlwdlSTGKCLGTLRGH 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24655809  274 KDSLTGLAYCPTLDIVASCGDD-SIKIHsitNLQETERIITVPDH-AGVQMIDWSPDGQLLAVTTNHGTVYIY 344
Cdd:cd00200  219 ENGVNSVAFSPDGYLLASGSEDgTIRVW---DLRTGECVQTLSGHtNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
27-179 3.57e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 3.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   27 LLATTGTDGSVALYNRQGQLVQRII--LSGLCSGFAWDQEGDLLgIITSGSPNITLWDYNSQEKISVETGLRDPLTCILW 104
Cdd:COG2319  260 LLASGSADGTVRLWDLATGELLRTLtgHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24655809  105 SKQQQLLAVGTGRGNLAIYNHSSGKRPTPVLGkHSKRITCGAWSAQ-NLLALGSEDKsfslsnedgdTVRVVQLRD 179
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDgRTLASGSADG----------TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 27-195 2.10e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 2.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   27 LLATTGTDGSVALYN-RQGQLVQRIIL-SGLCSGFAWDQEGDLlgiITSGSPN--ITLWDYNSQEKISVETGLRDPLTCI 102
Cdd:cd00200  107 ILSSSSRDKTIKVWDvETGKCLTTLRGhTDWVNSVAFSPDGTF---VASSSQDgtIKLWDLRTGKCVATLTGHTGEVNSV 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  103 LWSKQQQLLAVGTGRGNLAIYNHSSGKrPTPVLGKHSKRITCGAWS-AQNLLALGSEDKS---FSLSNED------GDTV 172
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLSTGK-CLGTLRGHENGVNSVAFSpDGYLLASGSEDGTirvWDLRTGEcvqtlsGHTN 262

                        170       180
                 ....*....|....*....|...
gi 24655809  173 RVVQLRDAPTDMYFAEMANDERI 195
Cdd:cd00200  263 SVTSLAWSPDGKRLASGSADGTI 285
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 731-1024 3.60e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  731 QYDQAKEHMLKGV-------YTRAAL-DLCRDLLQWDQALLL---AHKNDPQEVPY---IAREYAQQlefnGNYTDALYH 796
Cdd:COG2956   23 QPDKAIDLLEEALeldpetvEAHLALgNLYRRRGEYDRAIRIhqkLLERDPDRAEAlleLAQDYLKA----GLLDRAEEL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  797 YEKgykedlinsketetdaLMDSSPEYEEHVRLckmgIARTSIRAGDFRRGIQYAVELEDQQLlfDCAELLatvghlTEA 876
Cdd:COG2956   99 LEK----------------LLELDPDDAEALRL----LAEIYEQEGDWEKAIEVLERLLKLGP--ENAHAY------CEL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  877 AGLYERGGFYDEAcghyiaLKMWNKANNILPKvkSTKLHAAYAKAKENDGHYEEAIRSYRIAGDLDAcvriyldhlcdph 956
Cdd:COG2956  151 AELYLEQGDYDEA------IEALEKALKLDPD--CARALLLLAELYLEQGDYEEAIAALERALEQDP------------- 209

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24655809  957 aaseivlesRSMDSAKLLAKFYQKIGDVEQALQFLvicgcvEEAFALAQRHNKLRRHGELLERYENAK 1024
Cdd:COG2956  210 ---------DYLPALPRLAELYEKLGDPEEALELL------RKALELDPSDDLLLALADLLERKEGLE 262
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-373 7.58e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 7.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809   96 RDPLTCILWSKQQQLLAVGTGRGNLAIYNHSSGKRPTpVLGKHSKRITCGAWSAQ-NLLALGSEDKsfslsnedgdTVRV 174
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTGPVRDVAASADgTYLASGSSDK----------TIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  175 VQLRdaptdmyfaemaNDERIagdnaismiigkRTLFlyylpepenptelGFQSRYGSLMQHKwfgDGYILLGFSNGHVV 254
Cdd:cd00200   78 WDLE------------TGECV------------RTLT-------------GHTSYVSSVAFSP---DGRILSSSSRDKTI 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  255 AIsthpkdvgqelWQVKN---------HKDSLTGLAYCPTLDIVASCGDD-SIKIHSITNLqetERIITVPDHAG-VQMI 323
Cdd:cd00200  118 KV-----------WDVETgkclttlrgHTDWVNSVAFSPDGTFVASSSQDgTIKLWDLRTG---KCVATLTGHTGeVNSV 183

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24655809  324 DWSPDGQLLAVTTNHGTVYIY---VTKLPHLF----------AVSAPRIVLLSSLAEVSIYVY 373
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWdlsTGKCLGTLrghengvnsvAFSPDGYLLASGSEDGTIRVW 246
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 280-362 4.34e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.42  E-value: 4.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809    280 LAYCPTLDIVA--SCgDDSIKIHSItNLQeteRIITVPDHAG---VQMIDWSPDGQLLAVTTNHGTVYI---YVTKLPHL 351
Cdd:pfam12894    1 MSWCPTMDLIAlaTE-DGELLLHRL-NWQ---RVWTLSPDKEdleVTSLAWRPDGKLLAVGYSDGTVRLldaENGKIVHH 75

                           90
                   ....*....|.
gi 24655809    352 FAVSAPRIVLL 362
Cdd:pfam12894   76 FSAGSDLITCL 86
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 876-1127 1.84e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  876 AAGLYERG------GFYDEAcghyiaLKMWNKANNILPKvkSTKLHAAYAKAKENDGHYEEAIRSYRIAGDLD-----AC 944
Cdd:COG2956    8 ALGWYFKGlnyllnGQPDKA------IDLLEEALELDPE--TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDpdraeAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809  945 VRIYLDHLC--DPHAASEIV-----LESRSMDSAKLLAKFYQKIGDVEQALQFLvicgcvEEAFAL----AQRHNKLRRH 1013
Cdd:COG2956   80 LELAQDYLKagLLDRAEELLeklleLDPDDAEALRLLAEIYEQEGDWEKAIEVL------ERLLKLgpenAHAYCELAEL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655809 1014 GELLERYENAKssDYL--ALAHYFEGEKYTLLAGKYYFLAREFTKALRFLLKASAFNNEEQVSLSLAIDCVATSNNEQLA 1091
Cdd:COG2956  154 YLEQGDYDEAI--EALekALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEA 231

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 24655809 1092 TQLIEFLLGEVDGVPkDPRYLFRLYMARKHYKDAAK 1127
Cdd:COG2956  232 LELLRKALELDPSDD-LLLALADLLERKEGLEAALA 266
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 269-344 5.39e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 5.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24655809  269 QVKNHKDSLTGLAYCPTLDIVAS-CGDDSIKIHsitNLQETERIITVPDHAG-VQMIDWSPDGQLLAVTTNHGTVYIY 344
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATgSGDGTIKVW---DLETGELLRTLKGHTGpVRDVAASADGTYLASGSSDKTIRLW 78
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 264-301 7.23e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 7.23e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 24655809     264 GQELWQVKNHKDSLTGLAYCPTLDIVASCGDD-SIKIHS 301
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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