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fkbp5 FKBP prolyl isomerase 5 [ Danio rerio (zebrafish) ]

Gene ID: 368924, updated on 9-Dec-2024

Summary

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Official Symbol
fkbp5provided by ZNC
Official Full Name
FKBP prolyl isomerase 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-630
See related
Ensembl:ENSDARG00000028396 AllianceGenome:ZFIN:ZDB-GENE-030616-630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:64082; wu:fc31g11; wu:fl87b03; si:zc263a23.8
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be active in cytoplasm. Is expressed in gut; head; liver; and regenerating fin. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See fkbp5 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (41091256..41116053)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (41098481..41118517)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene RAB44, member RAS oncogene family Neighboring gene serine and arginine rich splicing factor 3a Neighboring gene solute carrier family 6 member 22, tandem duplicate 1 Neighboring gene solute carrier family 6 member 22, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Global gene expression in larval zebrafish (Danio rerio) exposed to selective serotonin reuptake inhibitors (fluoxetine and sertraline) reveals unique expression profiles and potential biomarkers of exposure. Park JW, et al. Environ Pollut, 2012 Aug. PMID 22575097
  2. A chemical screening system for glucocorticoid stress hormone signaling in an intact vertebrate. Weger BD, et al. ACS Chem Biol, 2012 Jul 20. PMID 22545806, Free PMC Article
  3. Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism. Gans IM, et al. Front Cell Dev Biol, 2021. PMID 34692682, Free PMC Article
  4. Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood. Hartig EI, et al. BMC Res Notes, 2020 Aug 3. PMID 32746894, Free PMC Article
  5. Deleterious Effects of Overfeeding on Brain Homeostasis and Plasticity in Adult Zebrafish. Ghaddar B, et al. Zebrafish, 2021 Jun. PMID 34028307

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium.
    Title: FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP5
Names
FK506 binding protein 5
NP_998314.1
XP_021332470.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213149.2 → NP_998314.1  peptidyl-prolyl cis-trans isomerase FKBP5

    See identical proteins and their annotated locations for NP_998314.1

    Status: VALIDATED

    Source sequence(s)
    AL732567
    UniProtKB/TrEMBL
    A0A8M2BDK0, Q789J5, Q801U5
    Related
    ENSDARP00000038578.4, ENSDART00000028373.5
    Conserved Domains (5) summary
    smart00028
    Location:319 → 350
    TPR; Tetratricopeptide repeats
    COG0545
    Location:143 → 247
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:268 → 296
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:45 → 135
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13414
    Location:319 → 381
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    41091256..41116053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476795.2 → XP_021332470.1  peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDK0, A0A8M9QF85
    Related
    ENSDARP00000154791.1, ENSDART00000186884.1
    Conserved Domains (4) summary
    sd00006
    Location:272 → 300
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:49 → 139
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    cl26005
    Location:267 → 456
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    cl27578
    Location:147 → 251
    FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
Nucleotide Protein
Heading Accession and Version

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