Crtc3 CREB regulated transcription coactivator 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Crtc3provided by RGD
Full Name: CREB regulated transcription coactivator 3provided by RGD
Primary source: RGD:1309666
See related: EnsemblRapid:ENSRNOG00000011975 AllianceGenome:RGD:1309666
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309666
Summary: Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to cAMP; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and regulation of DNA-templated transcription. Predicted to act upstream of or within energy homeostasis and negative regulation of lipid catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human CRTC3 (CREB regulated transcription coactivator 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 76.1), Lung (RPKM 36.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (143962038..144064324, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (134552830..134655929, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (142398248..142500562, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF400181 (e-PCR)
- UniSTS:244864

RH137450 (e-PCR)
- UniSTS:219538

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP response element binding protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CREB-regulated transcription coactivator 3

Names: CREB-regulated transcription coactivator 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427241.1 → NP_001414170.1 CREB-regulated transcription coactivator 3

Status: INFERRED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K1A6

Related

ENSRNOP00000071763.2, ENSRNOT00000089591.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

143962038..144064324 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229463.5 → XP_006229525.1 CREB-regulated transcription coactivator 3 isoform X1

See identical proteins and their annotated locations for XP_006229525.1

UniProtKB/TrEMBL

A0A0G2K1A6

Conserved Domains (3) summary

pfam12884
Location:11 → 64

TORC_N; Transducer of regulated CREB activity, N terminus

pfam12885
Location:159 → 320

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:544 → 617

TORC_C; Transducer of regulated CREB activity, C terminus
XM_039101058.2 → XP_038956986.1 CREB-regulated transcription coactivator 3 isoform X2

UniProtKB/TrEMBL

A0A0G2K1A6, F1LVL6

Related

ENSRNOP00000015949.6, ENSRNOT00000015948.8

Conserved Domains (3) summary

pfam12884
Location:11 → 64

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:159 → 308

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:532 → 606

TORC_C; Transducer of regulated CREB activity, C-terminus