CREB-regulated transcription coactivator 3 isoform X2 [Rattus norvegicus]
CREB-regulated transcription coactivator( domain architecture ID 10583816)
CREB-regulated transcription coactivator enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding)
List of domain hits
Name | Accession | Description | Interval | E-value | |||
TORC_M | pfam12885 | Transducer of regulated CREB activity middle domain; This family includes the region between ... |
159-308 | 2.51e-67 | |||
Transducer of regulated CREB activity middle domain; This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet. : Pssm-ID: 463739 Cd Length: 154 Bit Score: 216.15 E-value: 2.51e-67
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TORC_C | pfam12886 | Transducer of regulated CREB activity, C terminus; This family includes the C terminal region ... |
532-606 | 7.44e-33 | |||
Transducer of regulated CREB activity, C terminus; This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs. : Pssm-ID: 463740 Cd Length: 75 Bit Score: 120.58 E-value: 7.44e-33
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TORC_N | pfam12884 | Transducer of regulated CREB activity, N terminus; This family includes the N terminal region ... |
11-64 | 3.60e-17 | |||
Transducer of regulated CREB activity, N terminus; This family includes the N terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS). The coiled-coil structure interacts with the bZIP domain of CREB. This interaction may occur via ionic bonds because it is disrupted under high-salt conditions. In addition to CREB-binding, the N-terminal region plays a role in the tetramer formation of TORCs, but the physiological function of the multimeric complex has not been clarified yet. : Pssm-ID: 463738 Cd Length: 63 Bit Score: 75.95 E-value: 3.60e-17
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Name | Accession | Description | Interval | E-value | |||
TORC_M | pfam12885 | Transducer of regulated CREB activity middle domain; This family includes the region between ... |
159-308 | 2.51e-67 | |||
Transducer of regulated CREB activity middle domain; This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet. Pssm-ID: 463739 Cd Length: 154 Bit Score: 216.15 E-value: 2.51e-67
|
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TORC_C | pfam12886 | Transducer of regulated CREB activity, C terminus; This family includes the C terminal region ... |
532-606 | 7.44e-33 | |||
Transducer of regulated CREB activity, C terminus; This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs. Pssm-ID: 463740 Cd Length: 75 Bit Score: 120.58 E-value: 7.44e-33
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TORC_N | pfam12884 | Transducer of regulated CREB activity, N terminus; This family includes the N terminal region ... |
11-64 | 3.60e-17 | |||
Transducer of regulated CREB activity, N terminus; This family includes the N terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS). The coiled-coil structure interacts with the bZIP domain of CREB. This interaction may occur via ionic bonds because it is disrupted under high-salt conditions. In addition to CREB-binding, the N-terminal region plays a role in the tetramer formation of TORCs, but the physiological function of the multimeric complex has not been clarified yet. Pssm-ID: 463738 Cd Length: 63 Bit Score: 75.95 E-value: 3.60e-17
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Name | Accession | Description | Interval | E-value | |||
TORC_M | pfam12885 | Transducer of regulated CREB activity middle domain; This family includes the region between ... |
159-308 | 2.51e-67 | |||
Transducer of regulated CREB activity middle domain; This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet. Pssm-ID: 463739 Cd Length: 154 Bit Score: 216.15 E-value: 2.51e-67
|
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TORC_C | pfam12886 | Transducer of regulated CREB activity, C terminus; This family includes the C terminal region ... |
532-606 | 7.44e-33 | |||
Transducer of regulated CREB activity, C terminus; This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs. Pssm-ID: 463740 Cd Length: 75 Bit Score: 120.58 E-value: 7.44e-33
|
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TORC_N | pfam12884 | Transducer of regulated CREB activity, N terminus; This family includes the N terminal region ... |
11-64 | 3.60e-17 | |||
Transducer of regulated CREB activity, N terminus; This family includes the N terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS). The coiled-coil structure interacts with the bZIP domain of CREB. This interaction may occur via ionic bonds because it is disrupted under high-salt conditions. In addition to CREB-binding, the N-terminal region plays a role in the tetramer formation of TORCs, but the physiological function of the multimeric complex has not been clarified yet. Pssm-ID: 463738 Cd Length: 63 Bit Score: 75.95 E-value: 3.60e-17
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Blast search parameters | ||||
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