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Gtf3c5 general transcription factor IIIC subunit 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362095, updated on 27-Nov-2024

Summary

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Official Symbol
Gtf3c5provided by RGD
Official Full Name
general transcription factor IIIC subunit 5provided by RGD
Primary source
RGD:1305173
See related
EnsemblRapid:ENSRNOG00000010981 AllianceGenome:RGD:1305173
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase III general transcription initiation factor activity. Predicted to contribute to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to act upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C5 (general transcription factor IIIC subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 49.1), Lung (RPKM 48.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gtf3c5 in Genome Data Viewer
Location:
3p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (32291851..32312188, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (11893867..11914187, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7144354..7164678, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator Neighboring gene carboxyl ester lipase Neighboring gene RNA, U6 small nuclear 592 Neighboring gene growth factor independent 1B transcriptional repressor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. Dumay-Odelot H, et al. J Biol Chem, 2007 Jun 8. PMID 17409385
  2. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23031840
  3. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase III general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase III promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIC complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
general transcription factor 3C polypeptide 5
Names
general transcription factor IIIC, polypeptide 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079941.1 → NP_001073410.1  general transcription factor 3C polypeptide 5

    See identical proteins and their annotated locations for NP_001073410.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129109
    UniProtKB/TrEMBL
    A1L1K6
    Related
    ENSRNOP00000015068.4, ENSRNOT00000015068.8
    Conserved Domains (1) summary
    pfam09734
    Location:24 → 322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    32291851..32312188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233835.5 → XP_006233897.1  general transcription factor 3C polypeptide 5 isoform X1

    Conserved Domains (1) summary
    pfam09734
    Location:24 → 322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

  2. XM_039105367.2 → XP_038961295.1  general transcription factor 3C polypeptide 5 isoform X2

    UniProtKB/TrEMBL
    A6JTP2
    Conserved Domains (1) summary
    pfam09734
    Location:43 → 197
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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