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Rasgrp2 RAS guanyl releasing protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361714, updated on 14-Nov-2024

Summary

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Official Symbol
Rasgrp2provided by RGD
Official Full Name
RAS guanyl releasing protein 2provided by RGD
Primary source
RGD:1311630
See related
EnsemblRapid:ENSRNOG00000021098 AllianceGenome:RGD:1311630
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; cellular response to calcium ion; and positive regulation of GTPase activity. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 149.7), Thymus (RPKM 118.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rasgrp2 in Genome Data Viewer
Location:
1q43
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213135034..213152246)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203705777..203722993)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221771238..221788765)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483960 Neighboring gene U7 small nuclear RNA Neighboring gene splicing factor 1 Neighboring gene uncharacterized LOC120097407 Neighboring gene glycogen phosphorylase, muscle associated Neighboring gene neurexin 2 Neighboring gene solute carrier family 22 member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding. Canault M, et al. J Exp Med, 2014 Jun 30. PMID 24958846, Free PMC Article
  2. Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. Clyde-Smith J, et al. J Biol Chem, 2000 Oct 13. PMID 10918068
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RAS guanyl-releasing protein 2
Names
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
calDAG-GEFI
calcium and DAG-regulated guanine nucleotide exchange factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082977.2 → NP_001076446.2  RAS guanyl-releasing protein 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P0C643
    UniProtKB/TrEMBL
    A6HZH1
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213135034..213152246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230854.5 → XP_006230916.1  RAS guanyl-releasing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006230916.1

    UniProtKB/Swiss-Prot
    P0C643
    UniProtKB/TrEMBL
    A6HZH1
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  2. XM_063268258.1 → XP_063124328.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HZH1

  3. XM_063268277.1 → XP_063124347.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HZH1

  4. XM_063268267.1 → XP_063124337.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HZH1

  5. XM_063268269.1 → XP_063124339.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HZH1

  6. XM_039083977.2 → XP_038939905.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P0C643
    UniProtKB/TrEMBL
    A6HZH1
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  7. XM_006230853.3 → XP_006230915.1  RAS guanyl-releasing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006230915.1

    UniProtKB/Swiss-Prot
    P0C643
    UniProtKB/TrEMBL
    A6HZH1
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  8. XM_039084004.1 → XP_038939932.1  RAS guanyl-releasing protein 2 isoform X3

    UniProtKB/TrEMBL
    A6HZH4
    Related
    ENSRNOP00000102158.1, ENSRNOT00000162040.1
    Conserved Domains (1) summary
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

  9. XM_006230857.3 → XP_006230919.1  RAS guanyl-releasing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006230919.1

    UniProtKB/Swiss-Prot
    P0C643
    UniProtKB/TrEMBL
    A6HZH1
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  10. XM_063268263.1 → XP_063124333.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HZH1
    Related
    ENSRNOP00000028646.7, ENSRNOT00000028646.8

  11. XM_063268278.1 → XP_063124348.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HZH1

  12. XM_006230855.5 → XP_006230917.1  RAS guanyl-releasing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006230917.1

    UniProtKB/Swiss-Prot
    P0C643
    UniProtKB/TrEMBL
    A6HZH1
    Conserved Domains (4) summary
    smart00147
    Location:150 → 387
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:7 → 121
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:430 → 481
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:496 → 551
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

  13. XM_063268264.1 → XP_063124334.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HZH1

  14. XM_063268283.1 → XP_063124353.1  RAS guanyl-releasing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HZH1

  15. XM_039083991.2 → XP_038939919.1  RAS guanyl-releasing protein 2 isoform X2

    Conserved Domains (3) summary
    smart00147
    Location:5 → 242
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00051
    Location:285 → 336
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20861
    Location:351 → 406
    C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C643.1 GenPept UniProtKB/Swiss-Prot:P0C643

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