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Conserved domains on  [gi|1958647848|ref|XP_038939932|]
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RAS guanyl-releasing protein 2 isoform X3 [Rattus norvegicus]

Protein Classification

Ras-GEF domain-containing protein( domain architecture ID 10643694)

Ras guanine nucleotide exchange factor (Ras-GEF) domain-containing protein activates Ras-like small GTPases by mediating the replacement of GDP with GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
 7-121 3.20e-27

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


:

Pssm-ID: 214571  Cd Length: 127  Bit Score: 97.79  E-value: 3.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647848    7 LDKGCTVEELLRGCIEAFDDsgkvRDPQLVRMFLMMHPWYIPSSQLASKLLHFYQ-------QSRKDNSNSLQVKTCHLV 79
Cdd:smart00229   4 LIKGGTLEALIEHLTEAFDK----ADPSFVETFLLTYRSFITTQELLQLLLYRYNaippeswVEEKVNPRRVKNRVLNIL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958647848   80 RYWVSAFPAEFDLNPELAEQIKELKALLDQE-GNRRHSSLIDI 121
Cdd:smart00229  80 RTWVENYWEDFEDDPKLISFLLEFLELVDDEkYPGLVTSLLNL 122
 
Name Accession Description Interval E-value
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
 7-121 3.20e-27

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 97.79  E-value: 3.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647848    7 LDKGCTVEELLRGCIEAFDDsgkvRDPQLVRMFLMMHPWYIPSSQLASKLLHFYQ-------QSRKDNSNSLQVKTCHLV 79
Cdd:smart00229   4 LIKGGTLEALIEHLTEAFDK----ADPSFVETFLLTYRSFITTQELLQLLLYRYNaippeswVEEKVNPRRVKNRVLNIL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958647848   80 RYWVSAFPAEFDLNPELAEQIKELKALLDQE-GNRRHSSLIDI 121
Cdd:smart00229  80 RTWVENYWEDFEDDPKLISFLLEFLELVDDEkYPGLVTSLLNL 122
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
 12-123 1.02e-20

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 81.30  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647848  12 TVEELLRGCIEAFDDSgkvrDPQLVRMFLMMHPWYIPSSQLASKLLHFYQ----------QSRKDNSNSLQVKTCHLVRY 81
Cdd:cd06224     1 TLEALIEHLTSTFDMP----DPSFVSTFLLTYRSFTTPTELLEKLIERYEiappenleynDWDKKKSKPIRLRVLNVLRT 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958647848  82 WVSAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIES 123
Cdd:cd06224    77 WVENYPYDFFDDEELLELLEEFLNRLVQEGALLQELKKLLRK 118
 
Name Accession Description Interval E-value
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
 7-121 3.20e-27

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 97.79  E-value: 3.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647848    7 LDKGCTVEELLRGCIEAFDDsgkvRDPQLVRMFLMMHPWYIPSSQLASKLLHFYQ-------QSRKDNSNSLQVKTCHLV 79
Cdd:smart00229   4 LIKGGTLEALIEHLTEAFDK----ADPSFVETFLLTYRSFITTQELLQLLLYRYNaippeswVEEKVNPRRVKNRVLNIL 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958647848   80 RYWVSAFPAEFDLNPELAEQIKELKALLDQE-GNRRHSSLIDI 121
Cdd:smart00229  80 RTWVENYWEDFEDDPKLISFLLEFLELVDDEkYPGLVTSLLNL 122
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
 12-123 1.02e-20

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 81.30  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647848  12 TVEELLRGCIEAFDDSgkvrDPQLVRMFLMMHPWYIPSSQLASKLLHFYQ----------QSRKDNSNSLQVKTCHLVRY 81
Cdd:cd06224     1 TLEALIEHLTSTFDMP----DPSFVSTFLLTYRSFTTPTELLEKLIERYEiappenleynDWDKKKSKPIRLRVLNVLRT 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958647848  82 WVSAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIES 123
Cdd:cd06224    77 WVENYPYDFFDDEELLELLEEFLNRLVQEGALLQELKKLLRK 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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