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Mad1 Mitotic arrest-deficient 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35954, updated on 27-Dec-2024

Summary

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Official Symbol
Mad1provided by FlyBase
Official Full Name
Mitotic arrest-deficient 1provided by FlyBase
Primary source
FLYBASE:FBgn0026326
Locus tag
Dmel_CG2072
See related
AllianceGenome:FB:FBgn0026326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2072; Dmel\CG2072; mad1; TXBP181-like
Summary
Involved in attachment of mitotic spindle microtubules to kinetochore and mitotic spindle assembly checkpoint signaling. Located in kinetochore; nuclear envelope; and nucleoplasm. Colocalizes with mitotic spindle. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; cuboidal/columnar epithelium; embryonic/larval midgut primordium; and ganglia. Used to study microcephaly. Human ortholog(s) of this gene implicated in lymphoma; mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition; and prostate cancer. Orthologous to human MAD1L1 (mitotic arrest deficient 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Mad1 in Genome Data Viewer
Location:
45C4-45C4; 2-60 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9288957..9291565, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5176462..5179070, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Protein kinase N Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45132 Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 6 Neighboring gene DNA fragmentation factor-related protein 2 Neighboring gene Myd88

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila. Raich N, et al. Open Biol, 2018 Oct 17. PMID 30333236, Free PMC Article
  2. Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway. Ye AA, et al. Curr Biol, 2015 Jul 20. PMID 26166783, Free PMC Article
  3. Insights from an erroneous kinetochore-microtubule attachment state. Cane S, et al. Bioarchitecture, 2013 May-Jun. PMID 23887229, Free PMC Article
  4. RZZ and Mad1 dynamics in Drosophila mitosis. Défachelles L, et al. Chromosome Res, 2015 Jun. PMID 25772408, Free PMC Article
  5. Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. Cunha-Silva S, et al. J Cell Biol, 2020 Mar 2. PMID 31913420, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation.
    Title: Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation.
  2. these results suggest that Drosophila Mad1, by helping organize its interphase protein partners in the nucleoplasm, contributes to proper chromatin regulation.
    Title: Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitotic arrest-deficient 1
Names
CG2072-PA
Mad1-PA
TXBP181-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9288957..9291565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136633.4 → NP_610477.2  mitotic arrest-deficient 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610477.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KND8, Q95S25
    Related
    FBpp0087680
    Conserved Domains (1) summary
    pfam05557
    Location:80 → 726
    MAD; Mitotic checkpoint protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KND8 Q7KND8
Q95S25 Q95S25

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
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