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lea-1 Plant Late Embryo Abundant (LEA) related [ Caenorhabditis elegans ]

Gene ID: 3564838, updated on 4-Jan-2025

Summary

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Official Symbol
lea-1
Official Full Name
Plant Late Embryo Abundant (LEA) related
Primary source
WormBase:WBGene00002263
Locus tag
CELE_K08H10.1
See related
AllianceGenome:WB:WBGene00002263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lipid binding activity. Involved in hyperosmotic response; response to desiccation; and response to heat. Predicted to be located in extracellular region. Is expressed in several structures, including excretory cell; germ line; head; intestine; and tail neurons. Orthologous to human PLIN4 (perilipin 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lea-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
12
Sequence:
Chromosome: V; NC_003283.11 (10011923..10028168)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nucleoside-diphosphatase uda-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase;Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential gene expression during desiccation stress in the insect-killing nematode Steinernema feltiae IS-6. Gal TZ, et al. J Parasitol, 2003 Aug. PMID 14533688
  2. Desiccation-induced structuralization and glass formation of group 3 late embryogenesis abundant protein model peptides. Shimizu T, et al. Biochemistry, 2010 Feb 16. PMID 20028138
  3. Accumulation of Glycogen and Upregulation of LEA-1 in C. elegans daf-2(e1370) Support Stress Resistance, Not Longevity. Zečić A, et al. Cells, 2022 Jan 12. PMID 35053361, Free PMC Article
  4. LEA motifs promote desiccation tolerance in vivo. Hibshman JD, et al. BMC Biol, 2021 Dec 14. PMID 34903234, Free PMC Article
  5. An LEA group 3 family member is involved in survival of C. elegans during exposure to stress. Gal TZ, et al. FEBS Lett, 2004 Nov 5. PMID 15527756

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LEA motifs promote desiccation tolerance in vivo.
    Title: LEA motifs promote desiccation tolerance in vivo.
  2. Accumulation of Glycogen and Upregulation of LEA-1 in C. elegans daf-2(e1370) Support Stress Resistance, Not Longevity.
    Title: Accumulation of Glycogen and Upregulation of LEA-1 in C. elegans daf-2(e1370) Support Stress Resistance, Not Longevity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hyperosmotic response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to desiccation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to desiccation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Plant Late Embryo Abundant (LEA) related
NP_001256160.1
  • Confirmed by transcript evidence
NP_001256161.1
  • Confirmed by transcript evidence
NP_001256162.1
  • Confirmed by transcript evidence
NP_001256163.1
  • Confirmed by transcript evidence
NP_001256164.1
  • Confirmed by transcript evidence
NP_001256165.1
  • Confirmed by transcript evidence
NP_001256169.1
  • Confirmed by transcript evidence
NP_001256170.1
  • Confirmed by transcript evidence
NP_001256171.1
  • Confirmed by transcript evidence
NP_001256173.1
  • Confirmed by transcript evidence
NP_001256174.1
  • Confirmed by transcript evidence
NP_001360513.1
  • Confirmed by transcript evidence
NP_001360514.1
  • Confirmed by transcript evidence
NP_001360515.1
  • Confirmed by transcript evidence
NP_001360516.1
  • Confirmed by transcript evidence
NP_001360517.1
  • Confirmed by transcript evidence
NP_001360518.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10011923..10028168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373086.2 → NP_001360514.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WVD1
    Conserved Domains (2) summary
    PTZ00121
    Location:760 → 1269
    PTZ00121; MAEBL; Provisional
    pfam01442
    Location:275 → 458
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  2. NM_001373085.2 → NP_001360513.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WUR9
    Conserved Domains (2) summary
    PTZ00121
    Location:452 → 1141
    PTZ00121; MAEBL; Provisional
    PRK05035
    Location:1060 → 1294
    PRK05035; electron transport complex protein RnfC; Provisional

  3. NM_001269232.3 → NP_001256161.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLK7
    Conserved Domains (2) summary
    pfam01442
    Location:821 → 989
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl01888
    Location:761 → 830
    DUF883; Bacterial protein of unknown function (DUF883)

  4. NM_001269231.3 → NP_001256160.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256160.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLL1
    Conserved Domains (2) summary
    pfam01442
    Location:945 → 1113
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl01888
    Location:885 → 954
    DUF883; Bacterial protein of unknown function (DUF883)

  5. NM_001269233.4 → NP_001256162.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLK5
    Conserved Domains (1) summary
    pfam01442
    Location:214 → 371
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  6. NM_001269234.3 → NP_001256163.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLK8
    Conserved Domains (2) summary
    pfam01442
    Location:929 → 1097
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl01888
    Location:869 → 938
    DUF883; Bacterial protein of unknown function (DUF883)

  7. NM_001373087.2 → NP_001360515.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WVH0
    Conserved Domains (2) summary
    PTZ00121
    Location:436 → 1125
    PTZ00121; MAEBL; Provisional
    PRK05035
    Location:1044 → 1278
    PRK05035; electron transport complex protein RnfC; Provisional

  8. NM_001373088.2 → NP_001360516.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WWP8
    Conserved Domains (2) summary
    PTZ00121
    Location:744 → 1253
    PTZ00121; MAEBL; Provisional
    pfam01442
    Location:259 → 442
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  9. NM_001269235.3 → NP_001256164.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256164.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLK9
    Conserved Domains (2) summary
    pfam01442
    Location:805 → 973
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl01888
    Location:745 → 814
    DUF883; Bacterial protein of unknown function (DUF883)

  10. NM_001269236.3 → NP_001256165.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256165.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLK3
    Conserved Domains (1) summary
    pfam01442
    Location:198 → 355
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  11. NM_001269242.2 → NP_001256171.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256171.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFU3
    Conserved Domains (1) summary
    pfam01442
    Location:126 → 283
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  12. NM_001269241.4 → NP_001256170.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256170.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDH9
    Conserved Domains (2) summary
    pfam01442
    Location:733 → 901
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl01888
    Location:673 → 742
    DUF883; Bacterial protein of unknown function (DUF883)

  13. NM_001269240.3 → NP_001256169.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256169.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEF0
    Conserved Domains (2) summary
    pfam01442
    Location:857 → 1025
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl01888
    Location:797 → 866
    DUF883; Bacterial protein of unknown function (DUF883)

  14. NM_001373089.2 → NP_001360517.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WXP6
    Conserved Domains (2) summary
    PTZ00121
    Location:364 → 1053
    PTZ00121; MAEBL; Provisional
    PRK05035
    Location:972 → 1206
    PRK05035; electron transport complex protein RnfC; Provisional

  15. NM_001373090.2 → NP_001360518.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WTP6
    Conserved Domains (1) summary
    PTZ00121
    Location:672 → 1181
    PTZ00121; MAEBL; Provisional

  16. NM_001269244.3 → NP_001256173.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256173.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBW6
    Conserved Domains (2) summary
    pfam01442
    Location:104 → 272
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl01888
    Location:44 → 113
    DUF883; Bacterial protein of unknown function (DUF883)

  17. NM_001269245.3 → NP_001256174.1  Plant Late Embryo Abundant (LEA) related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256174.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGB8
    Conserved Domains (2) summary
    pfam01442
    Location:104 → 272
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl01888
    Location:44 → 113
    DUF883; Bacterial protein of unknown function (DUF883)
Nucleotide Protein
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