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Tsp42Ec Tetraspanin 42Ec [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35612, updated on 9-Dec-2024

Summary

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Official Symbol
Tsp42Ecprovided by FlyBase
Official Full Name
Tetraspanin 42Ecprovided by FlyBase
Primary source
FLYBASE:FBgn0033124
Locus tag
Dmel_CG12847
See related
AllianceGenome:FB:FBgn0033124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12847; Dm.Tsp42Ec; Dmel\CG12847
Summary
Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and embryonic midgut chamber. Orthologous to human TSPAN19 (tetraspanin 19). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Tsp42Ec in Genome Data Viewer
Location:
42E5-42E5; 2-55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7006442..7008622)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2893947..2896127)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42Ea Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 42Ed Neighboring gene Tetraspanin 42Ee

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. Stotz SC, et al. PLoS One, 2012. PMID 23056495, Free PMC Article
  2. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Overend G, et al. Sci Rep, 2016 Jun 2. PMID 27250760, Free PMC Article
  3. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin H, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16129837, Free PMC Article
  4. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
  5. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin 42Ec
Names
CG12847-PA
Tsp42Ec-PA
tetraspanin 42E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7006442..7008622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078905.3 → NP_523629.1  tetraspanin 42Ec [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523629.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NB13, Q9V4G0
    Related
    FBpp0085511
    Conserved Domains (2) summary
    cd03127
    Location:104 → 193
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:7 → 221
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NB13 Q9NB13

Gene LinkOut

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