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Conserved domains on  [gi|17648063|ref|NP_523629|]
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tetraspanin 42Ec [Drosophila melanogaster]

Protein Classification

tetraspanin family protein( domain architecture ID 11992924)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

CATH:  1.10.1450.10
Gene Ontology:  GO:0016020
PubMed:  11756464|19709882|16024509|12575999
SCOP:  4001512
TCDB:  8.A.40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
8-219 1.29e-23

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 93.15  E-value: 1.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648063     8 VNFILYIVNIVFLIVGILLIVLGsIMLSDLSRFDVAGSGTDPNTIPICVTVLGGLIFVVSFFGCYGIFRQSVCMTGAYTS 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVG-VWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648063    88 MVFVLFILQLVLTCWVFVNRSAFLGDMSNLVN--------LLWDSHDYT--AMGVLEETFGCCGdtsytnynniglsvpg 157
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLLSNWLKksledgyrDWLDLYSCLnsALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17648063   158 tccgyldrqatcntpsvyqsrpGCSAKFEEFWNDNMDIIRWSGLGLCIFDLVVFLIAGALTN 219
Cdd:pfam00335 144 ----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL super family cl02781
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 137-192 4.75e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


The actual alignment was detected with superfamily member cd03155:

Pssm-ID: 351888 [Multi-domain]  Cd Length: 110  Bit Score: 35.79  E-value: 4.75e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17648063 137 FGCCGDTSYTNY---------NNIGLSVPGTCCGYLDRQATC--NTPS-VYQSRPGCSAKFEEFWNDN 192
Cdd:cd03155  42 FKCCGSNNYTDWqdsewinsnEANGRLVPDSCCKTVVDRCGClrDHPSnIYKVEGGCIPKLEDFLYDH 109
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
8-219 1.29e-23

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 93.15  E-value: 1.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648063     8 VNFILYIVNIVFLIVGILLIVLGsIMLSDLSRFDVAGSGTDPNTIPICVTVLGGLIFVVSFFGCYGIFRQSVCMTGAYTS 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVG-VWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648063    88 MVFVLFILQLVLTCWVFVNRSAFLGDMSNLVN--------LLWDSHDYT--AMGVLEETFGCCGdtsytnynniglsvpg 157
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLLSNWLKksledgyrDWLDLYSCLnsALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17648063   158 tccgyldrqatcntpsvyqsrpGCSAKFEEFWNDNMDIIRWSGLGLCIFDLVVFLIAGALTN 219
Cdd:pfam00335 144 ----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 104-193 4.55e-16

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 71.00  E-value: 4.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648063 104 FVNRSAFLGDMSNLVNLLWDSH----DYT-AMGVLEETFGCCGDTSYTNYNNIGLSVPGTCCgylDRQATCNTPSVYQSr 178
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYyvddDFQeAMDALQSTFECCGVNGPTDYLDLRLLVPSSCC---KGTDGNCGLNLYTE- 76

                        90
                ....*....|....*
gi 17648063 179 pGCSAKFEEFWNDNM 193
Cdd:cd03127  77 -GCLEKLVDFLRSNL 90
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 137-192 4.75e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 35.79  E-value: 4.75e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17648063 137 FGCCGDTSYTNY---------NNIGLSVPGTCCGYLDRQATC--NTPS-VYQSRPGCSAKFEEFWNDN 192
Cdd:cd03155  42 FKCCGSNNYTDWqdsewinsnEANGRLVPDSCCKTVVDRCGClrDHPSnIYKVEGGCIPKLEDFLYDH 109
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
8-219 1.29e-23

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 93.15  E-value: 1.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648063     8 VNFILYIVNIVFLIVGILLIVLGsIMLSDLSRFDVAGSGTDPNTIPICVTVLGGLIFVVSFFGCYGIFRQSVCMTGAYTS 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVG-VWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648063    88 MVFVLFILQLVLTCWVFVNRSAFLGDMSNLVN--------LLWDSHDYT--AMGVLEETFGCCGdtsytnynniglsvpg 157
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLLSNWLKksledgyrDWLDLYSCLnsALDSLQSEFGCCG---------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17648063   158 tccgyldrqatcntpsvyqsrpGCSAKFEEFWNDNMDIIRWSGLGLCIFDLVVFLIAGALTN 219
Cdd:pfam00335 144 ----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 104-193 4.55e-16

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 71.00  E-value: 4.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648063 104 FVNRSAFLGDMSNLVNLLWDSH----DYT-AMGVLEETFGCCGDTSYTNYNNIGLSVPGTCCgylDRQATCNTPSVYQSr 178
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYyvddDFQeAMDALQSTFECCGVNGPTDYLDLRLLVPSSCC---KGTDGNCGLNLYTE- 76

                        90
                ....*....|....*
gi 17648063 179 pGCSAKFEEFWNDNM 193
Cdd:cd03127  77 -GCLEKLVDFLRSNL 90
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 114-192 1.03e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 37.46  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648063 114 MSNLVNllwDSHDYTAMGVLEETFGCCGDTSYTNYNNIGL----SVPGTCCGYLDRQATCNTPSVYQSRPGCSAKFEEFW 189
Cdd:cd03166  19 ISNYNK---TNDFRKILDRMQKDLKCCGANNYTDWENIPSldtdSVPDSCCINVTKGCGINFDEKVIHLEGCVTKIEGWL 95


                ...
gi 17648063 190 NDN 192
Cdd:cd03166  96 KKN 98
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 137-192 4.75e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 35.79  E-value: 4.75e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17648063 137 FGCCGDTSYTNY---------NNIGLSVPGTCCGYLDRQATC--NTPS-VYQSRPGCSAKFEEFWNDN 192
Cdd:cd03155  42 FKCCGSNNYTDWqdsewinsnEANGRLVPDSCCKTVVDRCGClrDHPSnIYKVEGGCIPKLEDFLYDH 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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