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tyn trynity [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3354987, updated on 9-Dec-2024

Summary

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Official Symbol
tynprovided by FlyBase
Official Full Name
trynityprovided by FlyBase
Primary source
FLYBASE:FBgn0284435
Locus tag
Dmel_CG17131
See related
AllianceGenome:FB:FBgn0284435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17131; CG17131-ORFA; CG17131-ORFB; Dmel\CG17131; EP(X)1421; EP1421; l(1)G0259; P277; SP71; Tyn
Summary
Involved in several processes, including apical constriction; cell-matrix adhesion; and regulation of embryonic cell shape. Located in apical plasma membrane. Is expressed in trichome. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See tyn in Genome Data Viewer
Location:
1A1-1A1; 1-0 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (140318..200663)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (38595..97667)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 1A Neighboring gene long non-coding RNA:CR45473 Neighboring gene mir-4915 stem loop Neighboring gene long non-coding RNA:CR43863 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene G9a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Trynity controls epidermal barrier function and respiratory tube maturation in Drosophila by modulating apical extracellular matrix nano-patterning. Itakura Y, et al. PLoS One, 2018. PMID 30576352, Free PMC Article
  2. nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures. Chung YD, et al. Neuron, 2001 Feb. PMID 11239432
  3. Trynity models a tube valve in the Drosophila larval airway system. Wang Y, et al. Dev Biol, 2018 May 15. PMID 29518377
  4. Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila. Lee SK, et al. Nat Commun, 2018 Nov 23. PMID 30470739, Free PMC Article
  5. A family of genes encoding zona pellucida (ZP) domain proteins is expressed in various epithelial tissues during Drosophila embryogenesis. Jaźwińska A, et al. Gene Expr Patterns, 2004 Jul. PMID 15183308

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trynity is needed for efficient tracheal gas-filling in Drosophila embryos
    Title: Trynity models a tube valve in the Drosophila larval airway system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 149973-150355 mobile_element_type = transposon:INE-1{}4648
  • Loc: 155425-155930 mobile_element_type = transposon:INE-1{}4654
  • Loc: 158644-158727 mobile_element_type = transposon:INE-1{}4660
  • Loc: 160809-168004 mobile_element_type = transposon:roo{}4733
  • Loc: 168124-168274 mobile_element_type = transposon:INE-1{}4674
  • Loc: 168328-168947 mobile_element_type = transposon:INE-1{}4677
  • Loc: 180078-180176 mobile_element_type = transposon:INE-1{}4678
  • Loc: 180225-180273 mobile_element_type = transposon:INE-1{}4679
  • Loc: 185555-185624 mobile_element_type = transposon:1360{}4749
  • Loc: 192473-192505 mobile_element_type = transposon:INE-1{}4699
  • Loc: 193508-193913 mobile_element_type = transposon:INE-1{}4701
  • Loc: 194144-194188 mobile_element_type = transposon:INE-1{}4702
  • Loc: 195822-196233 mobile_element_type = transposon:INE-1{}4704

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apical constriction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
trynity
Names
CG17131-PA
CG17131-PB
CG17131-PC
CG17131-PD
CG17131-PE
CG17131-PF
EP1421
SP71
lethal (1) G0259
tyn-PA
tyn-PB
tyn-PC
tyn-PD
tyn-PE
tyn-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    140318..200663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382036.1 → NP_001368965.1  trynity, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS37, Q9U3X0, Q9W5Z0
    Conserved Domains (4) summary
    smart00241
    Location:382 → 598
    ZP; Zona pellucida (ZP) domain
    cd01099
    Location:131 → 210
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    pfam00024
    Location:236 → 327
    PAN_1; PAN domain
    pfam14295
    Location:46 → 97
    PAN_4; PAN domain

  2. NM_001297801.1 → NP_001284730.1  trynity, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284730.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS37, Q9U3X0, Q9W5Z0
    Conserved Domains (4) summary
    smart00241
    Location:382 → 598
    ZP; Zona pellucida (ZP) domain
    cd01099
    Location:131 → 210
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    pfam00024
    Location:236 → 327
    PAN_1; PAN domain
    pfam14295
    Location:46 → 97
    PAN_4; PAN domain

  3. NM_001297799.1 → NP_001284728.1  trynity, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284728.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS37, Q9U3X0, Q9W5Z0
    Conserved Domains (4) summary
    smart00241
    Location:382 → 598
    ZP; Zona pellucida (ZP) domain
    cd01099
    Location:131 → 210
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    pfam00024
    Location:236 → 327
    PAN_1; PAN domain
    pfam14295
    Location:46 → 97
    PAN_4; PAN domain

  4. NM_001297798.1 → NP_001284727.1  trynity, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284727.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS37, Q9U3X0, Q9W5Z0
    Conserved Domains (4) summary
    smart00241
    Location:382 → 598
    ZP; Zona pellucida (ZP) domain
    cd01099
    Location:131 → 210
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    pfam00024
    Location:236 → 327
    PAN_1; PAN domain
    pfam14295
    Location:46 → 97
    PAN_4; PAN domain

  5. NM_001038726.2 → NP_001033815.1  trynity, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033815.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS37, Q9U3X0, Q9W5Z0
    Conserved Domains (4) summary
    smart00241
    Location:382 → 598
    ZP; Zona pellucida (ZP) domain
    cd01099
    Location:131 → 210
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    pfam00024
    Location:236 → 327
    PAN_1; PAN domain
    pfam14295
    Location:46 → 97
    PAN_4; PAN domain

  6. NM_001031861.2 → NP_001027032.1  trynity, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027032.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS37, Q9U3X0, Q9W5Z0
    Conserved Domains (4) summary
    smart00241
    Location:382 → 598
    ZP; Zona pellucida (ZP) domain
    cd01099
    Location:131 → 210
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    pfam00024
    Location:236 → 327
    PAN_1; PAN domain
    pfam14295
    Location:46 → 97
    PAN_4; PAN domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MS37 Q8MS37

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