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Maf1 Maf1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3354925, updated on 4-Jan-2025

Summary

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Official Symbol
Maf1provided by FlyBase
Official Full Name
Maf1provided by FlyBase
Primary source
FLYBASE:FBgn0267861
Locus tag
Dmel_CG40196
See related
AllianceGenome:FB:FBgn0267861
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG40196; CR41604; dMaf1; Dmel\CG40196; Maf; maf1
Summary
Predicted to enable RNA polymerase III core binding activity. Involved in negative regulation of transcription by RNA polymerase III. Predicted to be active in nucleus. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Maf1 in Genome Data Viewer
Location:
41A1-41A1; 2-55 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1512810..1527095, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44042 Neighboring gene long non-coding RNA:CR44043 Neighboring gene lethal (2) 41Ab Neighboring gene Branched chain keto acid dehydrogenase E1 subunit beta Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NT_033778.4 Chromosome 2R Reference Release 6 plus ISO1 MT Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Emerging Roles for Maf1 beyond the Regulation of RNA Polymerase III Activity. Khanna A, et al. J Mol Biol, 2015 Aug 14. PMID 26173035, Free PMC Article
  2. Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth. Grewal SS. Biochim Biophys Acta, 2015 Jul. PMID 25497380
  3. Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Ureña E, et al. Proc Natl Acad Sci U S A, 2024 Jan 23. PMID 38241436, Free PMC Article
  4. RNA polymerase III limits longevity downstream of TORC1. Filer D, et al. Nature, 2017 Dec 14. PMID 29186112, Free PMC Article
  5. Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. Marshall L, et al. EMBO J, 2012 Apr 18. PMID 22367393, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila RNA polymerase III repressor Maf1 (CG40196) controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling.
    Title: Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase III core binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Maf1
Names
CG40196-PA
CG40196-PB
CG40196-PC
CG40196-PD
CG40196-PE
Maf1-PA
Maf1-PB
Maf1-PC
Maf1-PD
Maf1-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    1512810..1527095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001110544.3 → NP_001104014.1  Maf1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104014.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL53, Q7PL26
    Conserved Domains (1) summary
    pfam09174
    Location:25 → 204
    Maf1; Maf1 regulator

  2. NM_001015168.4 → NP_001015168.2  Maf1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015168.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL53, Q7PL26
    Conserved Domains (1) summary
    pfam09174
    Location:25 → 204
    Maf1; Maf1 regulator

  3. NM_001300720.1 → NP_001287649.1  Maf1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287649.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL53, Q7PL26
    Conserved Domains (1) summary
    pfam09174
    Location:25 → 204
    Maf1; Maf1 regulator

  4. NM_001170411.1 → NP_001163882.1  Maf1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163882.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL53, Q7PL26
    Conserved Domains (1) summary
    pfam09174
    Location:25 → 204
    Maf1; Maf1 regulator

  5. NM_001015167.3 → NP_001015167.2  Maf1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015167.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL53, Q7PL26
    Conserved Domains (1) summary
    pfam09174
    Location:25 → 204
    Maf1; Maf1 regulator
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7PL26 Q7PL26

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