iars1 isoleucyl-tRNA synthetase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: iars1provided by ZNC
Official Full Name: isoleucyl-tRNA synthetase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6325
See related: Ensembl:ENSDARG00000007955 AllianceGenome:ZFIN:ZDB-GENE-030131-6325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: iars; fi46h05; zgc:63790; wu:fi46h05
Summary: Predicted to enable isoleucine-tRNA ligase activity. Acts upstream of or within regulation of sprouting angiogenesis. Is expressed in several structures, including brain; digestive system; optic cup; pectoral fin bud; and swim bladder. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (1337620..1392468, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (1311032..1365880, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in isoleucyl tRNA synthetase (iars(y68)) leads to increased branching angiogenesis in developing zebrafish.
Title: Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

Z7156 (e-PCR)
- UniSTS:47725

fi46h05.x1 (e-PCR)
- UniSTS:197589

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA editing activity	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables isoleucine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within isoleucyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: isoleucine--tRNA ligase, cytoplasmic

NP_956190.2

EC 6.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199896.2 → NP_956190.2 isoleucine--tRNA ligase, cytoplasmic

Status: VALIDATED

Source sequence(s)

CABZ01073866, CABZ01073867, CABZ01073868, CABZ01073869, CABZ01073870, CABZ01073871, CABZ01073872, CABZ01073873, CABZ01073874, CABZ01073875, CABZ01073876, EH583791, EH601215

UniProtKB/TrEMBL

A0A8N7UZX0

Related

ENSDARP00000009149.9, ENSDART00000004423.10

Conserved Domains (3) summary

cd07961
Location:640 → 833

Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases

cd00818
Location:39 → 640

IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases

PLN02882
Location:11 → 1070

PLN02882; aminoacyl-tRNA ligase