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CG10874 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33394, updated on 9-Dec-2024

Summary

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Official Symbol
CG10874provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031395
Locus tag
Dmel_CG10874
See related
AllianceGenome:FB:FBgn0031395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10874; FBgn 31395
Summary
Predicted to be involved in cilium assembly. Predicted to be located in centrosome. Is expressed in organism. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 1. Orthologous to human CCDC28A (coiled-coil domain containing 28A) and CCDC28B (coiled-coil domain containing 28B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG10874 in Genome Data Viewer
Location:
22D1-22D1; 2-5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2189914..2192386, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2189914..2192386, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Arginine-TCT 3-1 Neighboring gene long non-coding RNA:CR44066 Neighboring gene long non-coding RNA:CR45290 Neighboring gene antisense RNA:CR44065 Neighboring gene Cytochrome c oxidase subunit 7A-like 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw. Hao Y, et al. J Neurosci, 2019 Oct 23. PMID 31492772, Free PMC Article
  2. Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. Lehmann J, et al. BMC Evol Biol, 2010 May 26. PMID 20500887, Free PMC Article
  3. The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning. Hull R, et al. Int J Mol Sci, 2015 May 6. PMID 25955646, Free PMC Article
  4. Nociceptor-Enriched Genes Required for Normal Thermal Nociception. Honjo K, et al. Cell Rep, 2016 Jul 12. PMID 27346357, Free PMC Article
  5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10874-PA
CG10874-PB
CG10874-PC
CG10874-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2189914..2192386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164458.5 → NP_722768.2  uncharacterized protein Dmel_CG10874, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722768.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQ84
    Conserved Domains (1) summary
    pfam13270
    Location:121 → 209
    DUF4061; Domain of unknown function (DUF4061)

  2. NM_001258916.3 → NP_001245845.1  uncharacterized protein Dmel_CG10874, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKL4
    Conserved Domains (1) summary
    pfam13270
    Location:121 → 210
    DUF4061; Domain of unknown function (DUF4061)

  3. NM_134808.4 → NP_608652.1  uncharacterized protein Dmel_CG10874, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608652.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQ83
    Related
    FBpp0077520
    Conserved Domains (1) summary
    pfam13270
    Location:219 → 306
    DUF4061; Domain of unknown function (DUF4061)

  4. NM_001272982.2 → NP_001259911.1  uncharacterized protein Dmel_CG10874, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259911.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PB06
    Conserved Domains (1) summary
    pfam13270
    Location:219 → 307
    DUF4061; Domain of unknown function (DUF4061)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E4NKL4 E4NKL4
M9PB06 M9PB06
Q9VQ83 Q9VQ83
Q9VQ84 Q9VQ84

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