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Conserved domains on  [gi|386768982|ref|NP_001245845|]
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uncharacterized protein Dmel_CG10874, isoform C [Drosophila melanogaster]

Protein Classification

CCDC28 family protein( domain architecture ID 10594009)

CCDC28 family protein is a DUF4061 domain-containing protein; similar to homo sapiens coiled-coil domain containing 28A and 28B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC28 pfam13270
Coiled-coil domain-containing protein 28; This entry includes CCDC28A and CCDC28B. CCDC28B ...
 121-210 2.25e-38

Coiled-coil domain-containing protein 28; This entry includes CCDC28A and CCDC28B. CCDC28B modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation.


:

Pssm-ID: 463822  Cd Length: 88  Bit Score: 127.78  E-value: 2.25e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768982  121 PDVKHMERALLGLLDDFHSGKLRAFaGSGCTMDQMTKIREQQESLAKLHFELaAAEEDSLEHGNEFNTNKAQENMLQLMQ 200
Cdd:pfam13270   1 PDVRHMEEGLLQLLEDFHSGKLQAF-GKDCSMEQMEEIREQQEKLARLHFEL-GNEQEEFAEDEEDGLRESDENLTKLVS 78

                          90
                  ....*....|
gi 386768982  201 RLEQLSISIE 210
Cdd:pfam13270  79 NLEQLSSSIE 88
 
Name Accession Description Interval E-value
CCDC28 pfam13270
Coiled-coil domain-containing protein 28; This entry includes CCDC28A and CCDC28B. CCDC28B ...
 121-210 2.25e-38

Coiled-coil domain-containing protein 28; This entry includes CCDC28A and CCDC28B. CCDC28B modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation.


Pssm-ID: 463822  Cd Length: 88  Bit Score: 127.78  E-value: 2.25e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768982  121 PDVKHMERALLGLLDDFHSGKLRAFaGSGCTMDQMTKIREQQESLAKLHFELaAAEEDSLEHGNEFNTNKAQENMLQLMQ 200
Cdd:pfam13270   1 PDVRHMEEGLLQLLEDFHSGKLQAF-GKDCSMEQMEEIREQQEKLARLHFEL-GNEQEEFAEDEEDGLRESDENLTKLVS 78

                          90
                  ....*....|
gi 386768982  201 RLEQLSISIE 210
Cdd:pfam13270  79 NLEQLSSSIE 88
 
Name Accession Description Interval E-value
CCDC28 pfam13270
Coiled-coil domain-containing protein 28; This entry includes CCDC28A and CCDC28B. CCDC28B ...
 121-210 2.25e-38

Coiled-coil domain-containing protein 28; This entry includes CCDC28A and CCDC28B. CCDC28B modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation.


Pssm-ID: 463822  Cd Length: 88  Bit Score: 127.78  E-value: 2.25e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768982  121 PDVKHMERALLGLLDDFHSGKLRAFaGSGCTMDQMTKIREQQESLAKLHFELaAAEEDSLEHGNEFNTNKAQENMLQLMQ 200
Cdd:pfam13270   1 PDVRHMEEGLLQLLEDFHSGKLQAF-GKDCSMEQMEEIREQQEKLARLHFEL-GNEQEEFAEDEEDGLRESDENLTKLVS 78

                          90
                  ....*....|
gi 386768982  201 RLEQLSISIE 210
Cdd:pfam13270  79 NLEQLSSSIE 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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