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Gss1 Glutathione synthetase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32775, updated on 4-Jan-2025

Summary

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Official Symbol
Gss1provided by FlyBase
Official Full Name
Glutathione synthetase 1provided by FlyBase
Primary source
FLYBASE:FBgn0030882
Locus tag
Dmel_CG6835
See related
AllianceGenome:FB:FBgn0030882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6835; CG32497; CG33065; CG6835; Dmel\CG6835; GS; gss; GSS
Summary
Predicted to enable glutathione binding activity and glutathione synthase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Gss1 in Genome Data Viewer
Location:
16F1-16F1; 1-59 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17889547..17898603)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17783580..17792636)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene minibrain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Glutathione synthetase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of permissible maximum-contamination levels of VOC mixture in water on total DNA, antioxidant gene expression, and sequences of ribosomal DNA of Drosophila melanogaster. Doganlar O, et al. Environ Sci Pollut Res Int, 2015 Oct. PMID 26018283
  2. Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase. Ortiz JG, et al. Toxicol Sci, 2009 Feb. PMID 18779381, Free PMC Article
  3. Developmental ethanol exposure causes central nervous system dysfunction and may slow the aging process in a Drosophila model of fetal alcohol spectrum disorder. Belhorma K, et al. Alcohol, 2021 Aug. PMID 33961967
  4. Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila. Tsuda M, et al. FEBS Lett, 2010 Aug 4. PMID 20600005
  5. Drosophila embryos allocate lipid droplets to specific lineages to ensure punctual development and redox homeostasis. Kilwein MD, et al. PLoS Genet, 2023 Aug. PMID 37578970, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glutathione binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione synthetase 1
Names
CG6835-PE
CG6835-PF
CG6835-PG
CG6835-PH
CG6835-PI
CG6835-PJ
CG6835-PK
Gss1-PE
Gss1-PF
Gss1-PG
Gss1-PH
Gss1-PI
Gss1-PJ
Gss1-PK
glutathione synthase
glutathione synthetase
NP_001162782.1
NP_001162783.1
NP_001162784.1
NP_001285394.1
NP_573256.3
NP_788925.2
NP_788926.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17889547..17898603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176752.2 → NP_788925.2  glutathione synthetase 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788925.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A3FP33, A3FP35, Q86B44, Q8IQZ0
    Conserved Domains (1) summary
    pfam03917
    Location:20 → 552
    GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

  2. NM_001169311.1 → NP_001162782.1  glutathione synthetase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162782.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A3FP35, Q8IQZ1, Q8IQZ2
    Conserved Domains (1) summary
    pfam03917
    Location:20 → 481
    GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

  3. NM_133028.3 → NP_573256.3  glutathione synthetase 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573256.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX03
    Conserved Domains (1) summary
    cl00170
    Location:20 → 124
    eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

  4. NM_176753.2 → NP_788926.2  glutathione synthetase 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788926.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A3FP33, A3FP35, Q86B44, Q8IQZ0
    Conserved Domains (1) summary
    pfam03917
    Location:20 → 552
    GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

  5. NM_001169313.1 → NP_001162784.1  glutathione synthetase 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A3FP35, Q8IQZ1, Q8IQZ2
    Conserved Domains (1) summary
    pfam03917
    Location:20 → 481
    GSH_synth_ATP; Eukaryotic glutathione synthase, ATP binding domain

  6. NM_001169312.1 → NP_001162783.1  glutathione synthetase 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162783.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1RL06
    Conserved Domains (1) summary
    cl00170
    Location:20 → 232
    eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

  7. NM_001298465.1 → NP_001285394.1  glutathione synthetase 1, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285394.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCE7
    Conserved Domains (1) summary
    cl00170
    Location:20 → 124
    eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1RL06 Q1RL06
Q86B44 Q86B44
Q8IQZ1 Q8IQZ1
Q9VX03 Q9VX03
X2JCE7 X2JCE7

Gene LinkOut

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Research Materials
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