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Klhl4 kelch-like family member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317196, updated on 4-Jan-2025

Summary

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Official Symbol
Klhl4provided by RGD
Official Full Name
kelch-like family member 4provided by RGD
Primary source
RGD:1565441
See related
EnsemblRapid:ENSRNOG00000005215 AllianceGenome:RGD:1565441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565441
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in centriolar satellite. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL4 (kelch like family member 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 47.9), Brain (RPKM 42.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl4 in Genome Data Viewer
Location:
Xq31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (83626047..83916328)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (79429193..79719482)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (86125929..86229565)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene G3BP stress granule assembly factor 1, pseudogene 6 Neighboring gene uncharacterized LOC134484147 Neighboring gene influenza virus NS1A binding protein, pseudogene 2 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 4
Names
kelch-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108244.2 → NP_001101714.1  kelch-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001101714.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A6IVB0, D3ZHI3
    Related
    ENSRNOP00000006992.7, ENSRNOT00000006992.8
    Conserved Domains (6) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    PHA03098
    Location:175 → 697
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:465 → 508
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:171 → 275
    BTB; BTB/POZ domain
    pfam01344
    Location:464 → 509
    Kelch_1; Kelch motif
    pfam07707
    Location:283 → 382
    BACK; BTB And C-terminal Kelch

  2. NM_001434069.1 → NP_001420998.1  kelch-like protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  3. NM_001434070.1 → NP_001420999.1  kelch-like protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  4. NM_001434071.1 → NP_001421000.1  kelch-like protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    83626047..83916328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099723.2 → XP_038955651.1  kelch-like protein 4 isoform X2

    Conserved Domains (2) summary
    PHA03098
    Location:77 → 599
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:367 → 410
    Kelch; KELCH repeat [structural motif]

  2. XM_063280013.1 → XP_063136083.1  kelch-like protein 4 isoform X3

  3. XM_006257199.5 → XP_006257261.1  kelch-like protein 4 isoform X1

    UniProtKB/TrEMBL
    D3ZHI3
    Conserved Domains (6) summary
    smart00612
    Location:564 → 610
    Kelch; Kelch domain
    PHA03098
    Location:175 → 691
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:459 → 502
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:171 → 275
    BTB; BTB/POZ domain
    pfam01344
    Location:458 → 503
    Kelch_1; Kelch motif
    pfam07707
    Location:283 → 382
    BACK; BTB And C-terminal Kelch

  4. XM_039099724.2 → XP_038955652.1  kelch-like protein 4 isoform X4

    Conserved Domains (2) summary
    PHA03098
    Location:26 → 548
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:316 → 359
    Kelch; KELCH repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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