Pcnt pericentrin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcntprovided by RGD
Official Full Name: pericentrinprovided by RGD
Primary source: RGD:1595865
See related: EnsemblRapid:ENSRNOG00000001276 AllianceGenome:RGD:1595865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable molecular adaptor activity. Predicted to be involved in microtubule nucleation; mitotic spindle organization; and positive regulation of intracellular protein transport. Predicted to act upstream of or within several processes, including embryonic organ development; limb morphogenesis; and nervous system development. Predicted to be located in several cellular components, including cis-Golgi network; intercellular bridge; and microtubule organizing center. Human ortholog(s) of this gene implicated in microcephalic osteodysplastic primordial dwarfism type II. Orthologous to human PCNT (pericentrin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 102.2), Heart (RPKM 83.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (12189767..12278179)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (12190597..12278723)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (12943523..13038615)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH137318 (e-PCR)
- UniSTS:219406

D0Uwm4 (e-PCR)
- UniSTS:518750

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within brain morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar cortex morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within head development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within olfactory bulb development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pericentrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427002.1 → NP_001413931.1 pericentrin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

Related

ENSRNOP00000039329.5, ENSRNOT00000048218.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

12189767..12278179

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099203.2 → XP_038955131.1 pericentrin isoform X1

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (4) summary

PTZ00121
Location:154 → 858

PTZ00121; MAEBL; Provisional

COG1196
Location:1310 → 1561

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:1043 → 1434

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2754 → 2832

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
XM_039099208.2 → XP_038955136.1 pericentrin isoform X8

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (4) summary

PTZ00121
Location:154 → 858

PTZ00121; MAEBL; Provisional

COG1196
Location:1310 → 1561

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:1043 → 1434

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2714 → 2792

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
XM_039099209.2 → XP_038955137.1 pericentrin isoform X10

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (4) summary

PTZ00121
Location:154 → 858

PTZ00121; MAEBL; Provisional

COG1196
Location:2137 → 2479

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:1043 → 1434

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2677 → 2755

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
XM_063279161.1 → XP_063135231.1 pericentrin isoform X13
XM_017601880.3 → XP_017457369.1 pericentrin isoform X6

UniProtKB/TrEMBL

D3ZMY8
XM_063279159.1 → XP_063135229.1 pericentrin isoform X9
XM_039099210.2 → XP_038955138.1 pericentrin isoform X11

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (4) summary

PTZ00121
Location:154 → 858

PTZ00121; MAEBL; Provisional

COG1196
Location:2137 → 2461

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:1043 → 1434

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2659 → 2737

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
XM_063279162.1 → XP_063135232.1 pericentrin isoform X14
XM_039099205.2 → XP_038955133.1 pericentrin isoform X3

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (4) summary

PTZ00121
Location:154 → 858

PTZ00121; MAEBL; Provisional

COG1196
Location:1316 → 1554

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:1043 → 1427

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2747 → 2825

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
XM_039099206.2 → XP_038955134.1 pericentrin isoform X4

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (4) summary

PTZ00121
Location:154 → 858

PTZ00121; MAEBL; Provisional

COG1196
Location:1299 → 1550

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:1043 → 1423

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2743 → 2821

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
XM_006256312.5 → XP_006256374.1 pericentrin isoform X18

See identical proteins and their annotated locations for XP_006256374.1

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (7) summary

TIGR02168
Location:462 → 1423

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam07106
Location:1297 → 1405

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

pfam09455
Location:1050 → 1217

Cas_DxTHG; CRISPR-associated (Cas) DxTHG family

pfam10495
Location:2725 → 2803

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

pfam12474
Location:156 → 310

PKK; Polo kinase kinase

cd16269
Location:311 → 321

GBP_C; coiled coil [structural motif]

cl20817
Location:198 → 345

GBP_C; Guanylate-binding protein, C-terminal domain
XM_063279160.1 → XP_063135230.1 pericentrin isoform X12
XM_039099204.2 → XP_038955132.1 pericentrin isoform X2

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (3) summary

COG1196
Location:158 → 533

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:462 → 1433

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2753 → 2831

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
XM_039099207.2 → XP_038955135.1 pericentrin isoform X5

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (3) summary

COG1196
Location:158 → 533

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:462 → 1422

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:2742 → 2820

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
XM_002728936.6 → XP_002728982.2 pericentrin isoform X17

See identical proteins and their annotated locations for XP_002728982.2

UniProtKB/TrEMBL

D3ZMY8

Conserved Domains (7) summary

TIGR02168
Location:462 → 1422

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam07106
Location:1296 → 1404

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

pfam09455
Location:1049 → 1216

Cas_DxTHG; CRISPR-associated (Cas) DxTHG family

pfam10495
Location:2647 → 2725

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

pfam12474
Location:156 → 310

PKK; Polo kinase kinase

cd16269
Location:311 → 321

GBP_C; coiled coil [structural motif]

cl20817
Location:198 → 345

GBP_C; Guanylate-binding protein, C-terminal domain
XM_063279158.1 → XP_063135228.1 pericentrin isoform X7
XM_063279163.1 → XP_063135233.1 pericentrin isoform X15
XM_039099211.2 → XP_038955139.1 pericentrin isoform X16

Conserved Domains (3) summary

COG0419
Location:108 → 645

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

TIGR02168
Location:1391 → 1643

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10495
Location:1835 → 1913

PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein