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Sirt5 sirtuin 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306840, updated on 9-Dec-2024

Summary

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Official Symbol
Sirt5provided by RGD
Official Full Name
sirtuin 5provided by RGD
Primary source
RGD:1303285
See related
EnsemblRapid:ENSRNOG00000017866 AllianceGenome:RGD:1303285
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NAD+ binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and zinc ion binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to be located in cytosol; mitochondrial inner membrane; and mitochondrial intermembrane space. Predicted to be active in mitochondrial matrix. Orthologous to human SIRT5 (sirtuin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 365.5), Brain (RPKM 277.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sirt5 in Genome Data Viewer
Location:
17p14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (21515982..21543529, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (21310028..21337137, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (23986710..24013854)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene RAN binding protein 9 Neighboring gene U6 spliceosomal RNA Neighboring gene nucleolar protein 7 Neighboring gene uncharacterized LOC134482769 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke. Li J, et al. Neurochem Res, 2024 Apr. PMID 38170384
  2. The possible role of sirtuin 5 in the pathogenesis of apical periodontitis. Yang CN, et al. Oral Dis, 2021 Oct. PMID 33191606
  3. Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis. Zhang N, et al. Cell Mol Immunol, 2020 Nov. PMID 32099074, Free PMC Article
  4. SIRT5: a safeguard against oxidative stress-induced apoptosis in cardiomyocytes. Liu B, et al. Cell Physiol Biochem, 2013. PMID 24192575
  5. Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction. Wang Y, et al. Exp Cell Res, 2018 Oct 1. PMID 30098330

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
    Title: SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
  2. SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
    Title: SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
  3. The possible role of sirtuin 5 in the pathogenesis of apical periodontitis.
    Title: The possible role of sirtuin 5 in the pathogenesis of apical periodontitis.
  4. Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis.
    Title: Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis.
  5. Both diabetic rats and mice demonstrated significantly weakened SIRT5 expression in the pancreas, compared to wild-type animals, implying a possible correlation between SIRT5 and pancreatic beta cell function.
    Title: Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction.
  6. Caloric restriction (CR) retarded declines in cognitive ability and enhanced the expression of both SIRT1 and SIRT5 proteins in the cerebral tissue of CR rats compared with AL rats
    Title: SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction.
  7. Alcohol decreases mitochondrial SIRT5 level.
    Title: Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93823

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
  
enables NAD+ binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD-dependent protein lysine deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity, NAD-dependent IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glutaryllysine deglutarylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glutaryllysine deglutarylase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-malonyllysine demalonylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-malonyllysine demalonylase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-malonyllysine demalonylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-succinyllysine desuccinylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-succinyllysine desuccinylase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-succinyllysine desuccinylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine demalonylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine demalonylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within peptidyl-lysine desuccinylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine desuccinylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine desuccinylation ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in protein deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein deglutarylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein demalonylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein demalonylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein desuccinylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein desuccinylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of ketone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ketone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of succinate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to ischemia ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Names
NAD-dependent deacetylase sirtuin-5
NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
SIR2-like protein 5
regulatory protein SIR2 homolog 5
NP_001004256.1
XP_006253863.1
XP_006253864.1
XP_006253865.1
XP_006253866.1
XP_038951601.1
XP_063132446.1
XP_063132447.1
XP_063132448.1
XP_063132449.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004256.1 → NP_001004256.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial

    See identical proteins and their annotated locations for NP_001004256.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078958
    UniProtKB/Swiss-Prot
    Q68FX9
    UniProtKB/TrEMBL
    A6J749
    Related
    ENSRNOP00000024067.4, ENSRNOT00000024066.7
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    21515982..21543529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253801.3 → XP_006253863.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006253863.1

    UniProtKB/Swiss-Prot
    Q68FX9
    UniProtKB/TrEMBL
    A6J749
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  2. XM_006253802.3 → XP_006253864.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006253864.1

    UniProtKB/Swiss-Prot
    Q68FX9
    UniProtKB/TrEMBL
    A6J749
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  3. XM_039095673.2 → XP_038951601.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q68FX9
    UniProtKB/TrEMBL
    A6J749
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  4. XM_006253803.5 → XP_006253865.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006253865.1

    UniProtKB/Swiss-Prot
    Q68FX9
    UniProtKB/TrEMBL
    A6J749
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  5. XM_006253804.5 → XP_006253866.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006253866.1

    UniProtKB/Swiss-Prot
    Q68FX9
    UniProtKB/TrEMBL
    A6J749
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  6. XM_063276376.1 → XP_063132446.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  7. XM_063276377.1 → XP_063132447.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  8. XM_063276378.1 → XP_063132448.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  9. XM_063276379.1 → XP_063132449.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FX9.1 GenPept UniProtKB/Swiss-Prot:Q68FX9

Gene LinkOut

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