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Exo1 exonuclease 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305000, updated on 4-Jan-2025

Summary

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Official Symbol
Exo1provided by RGD
Official Full Name
exonuclease 1provided by RGD
Primary source
RGD:1309465
See related
EnsemblRapid:ENSRNOG00000056209 AllianceGenome:RGD:1309465
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity; DNA nuclease activity; and chromatin binding activity. Predicted to be involved in DNA recombination; DNA strand resection involved in replication fork processing; and mismatch repair. Predicted to act upstream of or within humoral immune response mediated by circulating immunoglobulin; isotype switching; and somatic hypermutation of immunoglobulin genes. Predicted to be located in nuclear body and plasma membrane. Predicted to be active in nucleus. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 35.8), Spleen (RPKM 21.1) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Exo1 in Genome Data Viewer
Location:
13q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (90341947..90366861)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (87809725..87834654)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (93936989..93962749)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692325 Neighboring gene ubiquitin-like modifier activating enzyme 2, pseudogene 1 Neighboring gene uncharacterized LOC134481598 Neighboring gene beclin 2 Neighboring gene phospholipase D family, member 5 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. Laulederkind SJ, et al. Database (Oxford), 2011. PMID 21321022, Free PMC Article
  2. Mechanism of 5'-directed excision in human mismatch repair. Genschel J, et al. Mol Cell, 2003 Nov. PMID 14636568
  3. Molecular interactions of human Exo1 with DNA. Lee Bi BI, et al. Nucleic Acids Res, 2002 Feb 15. PMID 11842105, Free PMC Article
  4. Human exonuclease I is required for 5' and 3' mismatch repair. Genschel J, et al. J Biol Chem, 2002 Apr 12. PMID 11809771
  5. The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities. Lee BI, et al. J Biol Chem, 1999 Dec 31. PMID 10608837

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5'-3' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA 5'-3' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables flap endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA 5'-3' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA strand resection involved in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within isotype switching ISO
Inferred from Sequence Orthology
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exonuclease 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107198.1 → NP_001100668.1  exonuclease 1

    See identical proteins and their annotated locations for NP_001100668.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473985
    UniProtKB/TrEMBL
    A6JGC0
    Related
    ENSRNOP00000073202.2, ENSRNOT00000088204.3
    Conserved Domains (2) summary
    cd09908
    Location:213 → 289
    H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
    cd09857
    Location:1 → 206
    PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    90341947..90366861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090805.2 → XP_038946733.1  exonuclease 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4W8
    Conserved Domains (2) summary
    cd09908
    Location:213 → 289
    H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
    cd09857
    Location:1 → 201
    PIN_EXO1; FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

  2. XM_039090806.2 → XP_038946734.1  exonuclease 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A158
    Related
    ENSRNOP00000084933.1, ENSRNOT00000110373.2
    Conserved Domains (2) summary
    cd09908
    Location:173 → 249
    H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
    cd09857
    Location:1 → 161
    PIN_EXO1; FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
Nucleotide Protein Strain
Heading Accession and Version

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