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tenm4 teneurin transmembrane protein 4 [ Danio rerio (zebrafish) ]

Gene ID: 30156, updated on 4-Jan-2025

Summary

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Official Symbol
tenm4provided by ZNC
Official Full Name
teneurin transmembrane protein 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-990714-20
See related
Ensembl:ENSDARG00000105088 AllianceGenome:ZFIN:ZDB-GENE-990714-20
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
odz4; ten-4; ten-m4
Summary
Predicted to enable cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Acts upstream of or within axon guidance. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including brain; midbrain hindbrain boundary neural rod; neural tube; optic vesicle; and retina. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See tenm4 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (10001466..10455463, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (10079292..10533098, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain-containing protein 3 Neighboring gene proline-rich proteoglycan 2-like Neighboring gene uncharacterized LOC137487718 Neighboring gene uncharacterized LOC110437888 Neighboring gene uncharacterized protein F54H12.2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptional silencing and reactivation in transgenic zebrafish. Goll MG, et al. Genetics, 2009 Jul. PMID 19433629, Free PMC Article
  2. Expression and Roles of Teneurins in Zebrafish. Cheung A, et al. Front Neurosci, 2019. PMID 30914911, Free PMC Article
  3. Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor. Hor H, et al. Hum Mol Genet, 2015 Oct 15. PMID 26188006, Free PMC Article
  4. Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Wang D, et al. J Hazard Mater, 2021 Jul 5. PMID 33621777
  5. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system myelin formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
teneurin-4
Names
protein Odd Oz/ten-m homolog 4
tenascin-M4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130969.2 → NP_571044.2  teneurin-4

    Status: VALIDATED

    Source sequence(s)
    AL807754, CU856523, CU928223, CU929551
    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A0R4IN22, A0A8N7UZE9
    Related
    ENSDARP00000136839.1, ENSDART00000165668.2
    Conserved Domains (10) summary
    COG3209
    Location:1737 → 2487
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1294 → 1331
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2438 → 2516
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:728 → 900
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1733 → 1768
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 411
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:702 → 728
    EGF_2; EGF-like domain
    pfam15636
    Location:2742 → 2817
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1284 → 1616
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:816 → 857
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    10001466..10455463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213455.1 → XP_068069556.1  teneurin-4 isoform X1

    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A2R8QIZ5, A0A8M3B0S9

  2. XM_009291510.4 → XP_009289785.1  teneurin-4 isoform X8

    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A8M3B0T4
    Related
    ENSDARP00000146538.1, ENSDART00000192971.1
    Conserved Domains (10) summary
    COG3209
    Location:1680 → 2430
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1230 → 1269
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2381 → 2459
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:625 → 773
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1676 → 1711
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 338
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:629 → 655
    EGF_2; EGF-like domain
    pfam15636
    Location:2685 → 2760
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1220 → 1559
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:743 → 784
    DSL; Delta serrate ligand

  3. XM_068213456.1 → XP_068069557.1  teneurin-4 isoform X5

    UniProtKB/Swiss-Prot
    Q9W7R3

  4. XM_009291511.4 → XP_009289786.1  teneurin-4 isoform X9

    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A8M3AIB8
    Conserved Domains (10) summary
    COG3209
    Location:1704 → 2454
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1261 → 1298
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2405 → 2483
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:695 → 867
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1700 → 1735
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 378
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:669 → 695
    EGF_2; EGF-like domain
    pfam15636
    Location:2709 → 2784
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1251 → 1583
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:783 → 824
    DSL; Delta serrate ligand

  5. XM_009291509.4 → XP_009289784.1  teneurin-4 isoform X7

    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A2R8RZ80, A0A8M3AH53
    Related
    ENSDARP00000156466.1, ENSDART00000185071.1
    Conserved Domains (10) summary
    COG3209
    Location:1711 → 2461
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1261 → 1300
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2412 → 2490
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:695 → 867
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1707 → 1742
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 378
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:669 → 695
    EGF_2; EGF-like domain
    pfam15636
    Location:2716 → 2791
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1251 → 1590
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:783 → 824
    DSL; Delta serrate ligand

  6. XM_009291508.4 → XP_009289783.1  teneurin-4 isoform X6

    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A8M3APL5
    Conserved Domains (10) summary
    COG3209
    Location:1720 → 2470
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1270 → 1309
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2421 → 2499
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:665 → 813
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1716 → 1751
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 378
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:669 → 695
    EGF_2; EGF-like domain
    pfam15636
    Location:2725 → 2800
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1260 → 1599
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:783 → 824
    DSL; Delta serrate ligand

  7. XM_005157483.5 → XP_005157540.1  teneurin-4 isoform X4

    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A0R4ICV6, A0A8M2B3L7
    Related
    ENSDARP00000132551.1, ENSDART00000162133.2
    Conserved Domains (10) summary
    COG3209
    Location:1744 → 2494
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1294 → 1333
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2445 → 2523
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:728 → 900
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1740 → 1775
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 411
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:702 → 728
    EGF_2; EGF-like domain
    pfam15636
    Location:2749 → 2824
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1284 → 1623
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:816 → 857
    DSL; Delta serrate ligand

  8. XM_009291505.4 → XP_009289780.1  teneurin-4 isoform X2

    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A8M3AIB4
    Conserved Domains (10) summary
    COG3209
    Location:1746 → 2496
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1303 → 1340
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2447 → 2525
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:698 → 846
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1742 → 1777
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 411
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:702 → 728
    EGF_2; EGF-like domain
    pfam15636
    Location:2751 → 2826
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1293 → 1625
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:816 → 857
    DSL; Delta serrate ligand

  9. XM_009291504.4 → XP_009289779.1  teneurin-4 isoform X1

    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A2R8QIZ5, A0A8M3B0S9
    Related
    ENSDARP00000155205.1, ENSDART00000192444.1
    Conserved Domains (10) summary
    COG3209
    Location:1753 → 2503
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1303 → 1342
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2454 → 2532
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:698 → 846
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1749 → 1784
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 411
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:702 → 728
    EGF_2; EGF-like domain
    pfam15636
    Location:2758 → 2833
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1293 → 1632
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:816 → 857
    DSL; Delta serrate ligand

  10. XM_009291506.4 → XP_009289781.1  teneurin-4 isoform X3

    UniProtKB/Swiss-Prot
    Q9W7R3
    UniProtKB/TrEMBL
    A0A8M3ASI0
    Conserved Domains (10) summary
    COG3209
    Location:1745 → 2495
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1295 → 1334
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2446 → 2524
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:690 → 838
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:1741 → 1776
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 403
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:694 → 720
    EGF_2; EGF-like domain
    pfam15636
    Location:2750 → 2825
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1285 → 1624
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:808 → 849
    DSL; Delta serrate ligand
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W7R3.1 GenPept UniProtKB/Swiss-Prot:Q9W7R3

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