|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-378 |
0e+00 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 613.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 11 SLT-SRRDTERRYTSSSADSEDGKIN-PKSYSSSETLKAFDQDSRLAYGSRVKDLVHHEADEFSRQGPDFSLRDMAFGDP 88
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 89 VPPHMAAYRTEMGLPHRDYSVSVASDADTETDGIMSPEHAVRLWGRsNTKSGRSSCLSSRANSNLTLTDTEHENT---EN 165
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGR-GTKSGRSSCLSSRSNSALTLTDTEHENKsdnEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 166 GPPLHCSSASSSPVD-SPYPPPShaANQSQGRLLGNSGAQAGRDSESEDEFGPNSFLVKTGSGNVCAPAAATANegsFQN 244
Cdd:pfam06484 160 GPPIPPSSSSSSPVEqHSPPPPS--LNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPN---FQN 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 245 HSRLRTPPLPLSHSHSPSQHHTASIGSLSRSNYTQRSNPSPAPTdSSAPNEGPTSaQDSSSAQDNWLLNSNVPLETRHFL 324
Cdd:pfam06484 235 HSRLRTPPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQST-QESVQLQDSWVLNSNVPLETRHFL 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 688587156 325 FKPG-GTSPLYCTTSPGYPLTSSTVYSPPPRPLPRNTFSRPAFSLKKPYKHCNWK 378
Cdd:pfam06484 313 FKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1251-1583 |
1.90e-40 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 153.84 E-value: 1.90e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1251 GLADGNKLLA----PVALACGSDGSLYVGDF--NYVRRIFTTGNVTSVLELSNS-------PAHKYY----LATSPvSGW 1313
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAgfadgggAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1314 LYLSDTSSRKVFKVkslyavkDVAKNLELVAGTGdqclpydETRCGDGGKAVEATLTNPRGITVDKYGVIFFVDGT--MI 1391
Cdd:cd14953 90 LYVADTGNHRIRKI-------TPDGVVSTLAGTG-------TAGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1392 RRIDQNGIISTLLGfndlTSARPLSCDSVMdiSQVRLEWPTDLAVSPMDNsLYVLD--NNVVLQISENHQVRIVAGRPMH 1469
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTGTA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1470 CQVPGLdhflvskIAIHATLESANALAVSHNGLLYIAESDEkkiNRVRQVSTNGEISLLAGAPSGcdckndancdcYSGD 1549
Cdd:cd14953 229 GFSGDG-------GATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....
gi 688587156 1550 DGYAKDAKLNAPSSLAVSPDGELFIADLGNIRIR 1583
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIR 321
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2707-2784 |
2.50e-33 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 124.26 E-value: 2.50e-33
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688587156 2707 EEKVRVLELARQRAVATAWAHERHRLRQGEEGSRAWTDGERQQLLSSGRVQGYEGFYIVSVDQFPELADNINNVHFLR 2784
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1539-2483 |
5.97e-32 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 137.19 E-value: 5.97e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1539 NDANCDCYSGDDGYAKDAKLNAPSSLAVSPDGELFIADLGNIRIRYVRRNKAFLNPLNMYEISSPIDDELYLFDVNASHV 1618
Cdd:COG3209 109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1619 FTQSLTTGDYLYNFTYSGEGDLSSITDKNKNRVSIRRDSTGLPLWLMGPDGQTFWFTMGTNNALKSVAAQGQEIAVMTYH 1698
Cdd:COG3209 189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1699 GSSGLLATKSNEDGWSTFYEYDNYGRLTNVTYPTGRVSSYRTDSDSTVRVQTEGSNKEDITVTTNLSASGTFYTlmQDQV 1778
Cdd:COG3209 269 ASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGT--GGTT 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1779 KNSYYIGLDGSLRLVLANGMEVSLHTEPHLLSGTVNPTISKRNVTLPIDNGLN-------LVEWRQRKEQARGQVTVYGR 1851
Cdd:COG3209 347 TTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSttgvgagTTTTSTTGGDGGPATAAGAL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1852 RLRVHNRNLLSMDFDRVTRTEKVYDDHRKFTLRIHYDHAGRPTLWAPSSRLNGVNVTYSPGGHIAGIQRGTMSVRMEYDQ 1931
Cdd:COG3209 427 TAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1932 NGRITSKIFADGKSWSYTYLEksmvLLLYSQRQYIFEFDKNDRLSSVTMPNVARQTLETTRSIGYYRNTYRPPEGNATVL 2011
Cdd:COG3209 507 GGTTTTTAGARGLVVTTGTTL----TLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTT 582
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2012 QDYSEDGLLLQTIHQGTGRRVIYKYGKLSRLLEILYDTTRIAFSYDESAGMLKTVGLQSEGFACTIRYRQIGPLIDRQIF 2091
Cdd:COG3209 583 GTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGT 662
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2092 RFSEEGMVNARFDYNYDNSFRVTSMQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYG 2171
Cdd:COG3209 663 TGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTG 742
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2172 RVKEVQYEIFRSLMYWMMvQYDNMGRVVAKELKVGPYANTTRYAYEYDADGQLQVVSINDKPLWRYSYDLNGNLHLLSPG 2251
Cdd:COG3209 743 TLTTTSTTTTTTAGALTY-TYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITV 821
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2252 NSARLTPL-----RYDIRDRITRLgdvqyrldEDGFLRQRGNDFFEYNSAGLLVKTYNKVNGWTikYRYDGLGRRVSSRS 2326
Cdd:COG3209 822 GSGGGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTD 891
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2327 TQGHHLQFFYADLssPTRVTHmynhSSLEITSLYYDLQGHlfamelssgdefyvaCDNIGTPLAVFSGAGLMIKQILHTA 2406
Cdd:COG3209 892 GGTTTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDP 950
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2407 FGEVYLDSNPSFQLVIGYQGGLYEPLTKLVHMGRRDYDVLAGRWTTPDhdiwkrlnsdnivP------FNLYMFKNNNPL 2480
Cdd:COG3209 951 FGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-------------PiglaggLNLYAYVGNNPV 1017
|
...
gi 688587156 2481 SNS 2483
Cdd:COG3209 1018 NYV 1020
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
862-892 |
3.15e-11 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 59.84 E-value: 3.15e-11
10 20 30
....*....|....*....|....*....|.
gi 688587156 862 SMETACSDGKDNDGDGLTDCMDPDCCLQASC 892
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2405-2483 |
3.16e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.58 E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2405 TAFGEVyLDSNPSFQLVIGYQGGLYEPLTKLVHMGRRDYDVLAGRWTTPDhdiwkrlnsdnivPF------NLYMFKNNN 2478
Cdd:TIGR03696 2 DPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGNN 67
|
....*
gi 688587156 2479 PLSNS 2483
Cdd:TIGR03696 68 PVNWV 72
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
602-886 |
6.19e-08 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 56.55 E-value: 6.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 602 DDCPSNCFGNGDCVSGNCH--------------CFPGFRGPDCSRASCpvlCSGngqylkgrCMCHSGwkgSECDVPTNQ 667
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASC---CGG--------VTCGAG---QTCDAKTNT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 668 CIDIT--CSGHGTCIVG--------TCICNPGYKGEnceevdcldptcSGRGvCVRGechcFVGWggpgcesprASCMEQ 737
Cdd:pfam19232 76 CVYVKgyCSADHPCPSGsacdtaknACIAQPPYGPD------------SGKG-CVRG----FGAW---------IWELDP 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 738 CSGHGSFladtnTCNCDHNW---TGHDCS----TELCAADCGGHGICVAGS---CRCDEGWmgtgceqrACHPRCSEHGT 807
Cdd:pfam19232 130 ATNSGVW-----RCRCANGSlynSAHECSpladQTLCAAENLDPNALVPASsvpAFAAYGW--------GNQPVLINKST 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 808 CKD-------GKCECSPGWNGEHCTIEGCpglCNGNGRCTLGNNGwyCVCQLGWRGAGcdtsmetacSDGKDNdgdGLTD 880
Cdd:pfam19232 197 AGAavpsplaGVCPCKPGWAGGSCTEDRT---CNGRGTWNETTGQ--CACNIDFSGHN---------SCGDDN---NCTS 259
|
....*.
gi 688587156 881 CMDPDC 886
Cdd:pfam19232 260 WTGPRC 265
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1261-1583 |
1.33e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 52.71 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1261 PVALACGSDGSLYVGDF--NYVRRI-FTTGNVTSVLELSNSPAHKyyLATSPvSGWLYLSDTSSRKVFKVkslyavkDVA 1337
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLdPATGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI-------DPK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1338 -KNLELVAGTGDQCLPYdetrcgdggkaveatltnprGITVDKYGVIFFVDGT--MIRRID-QNGIISTLLGFndLTSAR 1413
Cdd:COG4257 89 tGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPLP--TGGAG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1414 plscdsvmdisqvrlewPTDLAVSPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgldhflVSKIAIHATLESAN 1493
Cdd:COG4257 147 -----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYALPTPGAGPR 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1494 ALAVSHNGLLYIAESDEkkiNRVRQVSTN-GEISLLAGAPSGcdckndancdcysgddgyakdaklNAPSSLAVSPDGEL 1572
Cdd:COG4257 192 GLAVDPDGNLWVADTGS---GRIGRFDPKtGTVTEYPLPGGG------------------------ARPYGVAVDGDGRV 244
|
330
....*....|.
gi 688587156 1573 FIADLGNIRIR 1583
Cdd:COG4257 245 WFAESGANRIV 255
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1498-1589 |
3.64e-06 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 52.93 E-value: 3.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1498 SHNGLLYIAESDEKKINRVRQVStnGEISLLAGAPSGcdckndancdcySGDDGYAKDAKLNAPSSLAVSPDGELFIADL 1577
Cdd:PLN02919 812 AKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA------------GFKDGKALKAQLSEPAGLALGENGRLFVADT 877
|
90
....*....|..
gi 688587156 1578 GNIRIRYVRRNK 1589
Cdd:PLN02919 878 NNSLIRYLDLNK 889
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1700-1734 |
1.38e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 41.43 E-value: 1.38e-04
10 20 30
....*....|....*....|....*....|....*
gi 688587156 1700 SSGLLATKSNEDGWSTFYEYDNYGRLTNVTYPTGR 1734
Cdd:pfam05593 3 AAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1557-1651 |
3.31e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 44.97 E-value: 3.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1557 KLNAPSSLAVSPDGELFIADLGNIRIRYVRRNKAFLN----PLNMYEISSPI-----DDELYLFDVNASH--VFTQsltT 1625
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKFLKyfpeKKDRVKLISPAglaidDGKLYVSDVKKHKviVFDL---E 130
|
90 100 110
....*....|....*....|....*....|.
gi 688587156 1626 GDYLYNF--TYSGEGDLSS---ITDKNKNRV 1651
Cdd:cd14963 131 GKLLLEFgkPGSEPGELSYpngIAVDEDGNI 161
|
|
| DSL |
smart00051 |
delta serrate ligand; |
783-824 |
1.26e-03 |
|
delta serrate ligand;
Pssm-ID: 128366 Cd Length: 63 Bit Score: 39.24 E-value: 1.26e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 688587156 783 RCDEGWMGTGCE-------QRACHPRCSEHGtckdgKCECSPGWNGEHC 824
Cdd:smart00051 20 TCDENYYGEGCNkfcrprdDFFGHYTCDENG-----NKGCLEGWMGPYC 63
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
673-696 |
1.97e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.97e-03
10 20
....*....|....*....|....*...
gi 688587156 673 CSGHGTCI--VG--TCICNPGYKGENCE 696
Cdd:cd00054 11 CQNGGTCVntVGsyRCSCPPGYTGRNCE 38
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-378 |
0e+00 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 613.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 11 SLT-SRRDTERRYTSSSADSEDGKIN-PKSYSSSETLKAFDQDSRLAYGSRVKDLVHHEADEFSRQGPDFSLRDMAFGDP 88
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 89 VPPHMAAYRTEMGLPHRDYSVSVASDADTETDGIMSPEHAVRLWGRsNTKSGRSSCLSSRANSNLTLTDTEHENT---EN 165
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGR-GTKSGRSSCLSSRSNSALTLTDTEHENKsdnEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 166 GPPLHCSSASSSPVD-SPYPPPShaANQSQGRLLGNSGAQAGRDSESEDEFGPNSFLVKTGSGNVCAPAAATANegsFQN 244
Cdd:pfam06484 160 GPPIPPSSSSSSPVEqHSPPPPS--LNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPN---FQN 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 245 HSRLRTPPLPLSHSHSPSQHHTASIGSLSRSNYTQRSNPSPAPTdSSAPNEGPTSaQDSSSAQDNWLLNSNVPLETRHFL 324
Cdd:pfam06484 235 HSRLRTPPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQST-QESVQLQDSWVLNSNVPLETRHFL 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 688587156 325 FKPG-GTSPLYCTTSPGYPLTSSTVYSPPPRPLPRNTFSRPAFSLKKPYKHCNWK 378
Cdd:pfam06484 313 FKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1251-1583 |
1.90e-40 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 153.84 E-value: 1.90e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1251 GLADGNKLLA----PVALACGSDGSLYVGDF--NYVRRIFTTGNVTSVLELSNS-------PAHKYY----LATSPvSGW 1313
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAgfadgggAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1314 LYLSDTSSRKVFKVkslyavkDVAKNLELVAGTGdqclpydETRCGDGGKAVEATLTNPRGITVDKYGVIFFVDGT--MI 1391
Cdd:cd14953 90 LYVADTGNHRIRKI-------TPDGVVSTLAGTG-------TAGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1392 RRIDQNGIISTLLGfndlTSARPLSCDSVMdiSQVRLEWPTDLAVSPMDNsLYVLD--NNVVLQISENHQVRIVAGRPMH 1469
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTGTA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1470 CQVPGLdhflvskIAIHATLESANALAVSHNGLLYIAESDEkkiNRVRQVSTNGEISLLAGAPSGcdckndancdcYSGD 1549
Cdd:cd14953 229 GFSGDG-------GATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....
gi 688587156 1550 DGYAKDAKLNAPSSLAVSPDGELFIADLGNIRIR 1583
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIR 321
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2707-2784 |
2.50e-33 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 124.26 E-value: 2.50e-33
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688587156 2707 EEKVRVLELARQRAVATAWAHERHRLRQGEEGSRAWTDGERQQLLSSGRVQGYEGFYIVSVDQFPELADNINNVHFLR 2784
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1539-2483 |
5.97e-32 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 137.19 E-value: 5.97e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1539 NDANCDCYSGDDGYAKDAKLNAPSSLAVSPDGELFIADLGNIRIRYVRRNKAFLNPLNMYEISSPIDDELYLFDVNASHV 1618
Cdd:COG3209 109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1619 FTQSLTTGDYLYNFTYSGEGDLSSITDKNKNRVSIRRDSTGLPLWLMGPDGQTFWFTMGTNNALKSVAAQGQEIAVMTYH 1698
Cdd:COG3209 189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1699 GSSGLLATKSNEDGWSTFYEYDNYGRLTNVTYPTGRVSSYRTDSDSTVRVQTEGSNKEDITVTTNLSASGTFYTlmQDQV 1778
Cdd:COG3209 269 ASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGT--GGTT 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1779 KNSYYIGLDGSLRLVLANGMEVSLHTEPHLLSGTVNPTISKRNVTLPIDNGLN-------LVEWRQRKEQARGQVTVYGR 1851
Cdd:COG3209 347 TTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSttgvgagTTTTSTTGGDGGPATAAGAL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1852 RLRVHNRNLLSMDFDRVTRTEKVYDDHRKFTLRIHYDHAGRPTLWAPSSRLNGVNVTYSPGGHIAGIQRGTMSVRMEYDQ 1931
Cdd:COG3209 427 TAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1932 NGRITSKIFADGKSWSYTYLEksmvLLLYSQRQYIFEFDKNDRLSSVTMPNVARQTLETTRSIGYYRNTYRPPEGNATVL 2011
Cdd:COG3209 507 GGTTTTTAGARGLVVTTGTTL----TLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTT 582
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2012 QDYSEDGLLLQTIHQGTGRRVIYKYGKLSRLLEILYDTTRIAFSYDESAGMLKTVGLQSEGFACTIRYRQIGPLIDRQIF 2091
Cdd:COG3209 583 GTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGT 662
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2092 RFSEEGMVNARFDYNYDNSFRVTSMQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYG 2171
Cdd:COG3209 663 TGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTG 742
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2172 RVKEVQYEIFRSLMYWMMvQYDNMGRVVAKELKVGPYANTTRYAYEYDADGQLQVVSINDKPLWRYSYDLNGNLHLLSPG 2251
Cdd:COG3209 743 TLTTTSTTTTTTAGALTY-TYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITV 821
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2252 NSARLTPL-----RYDIRDRITRLgdvqyrldEDGFLRQRGNDFFEYNSAGLLVKTYNKVNGWTikYRYDGLGRRVSSRS 2326
Cdd:COG3209 822 GSGGGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTD 891
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2327 TQGHHLQFFYADLssPTRVTHmynhSSLEITSLYYDLQGHlfamelssgdefyvaCDNIGTPLAVFSGAGLMIKQILHTA 2406
Cdd:COG3209 892 GGTTTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDP 950
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2407 FGEVYLDSNPSFQLVIGYQGGLYEPLTKLVHMGRRDYDVLAGRWTTPDhdiwkrlnsdnivP------FNLYMFKNNNPL 2480
Cdd:COG3209 951 FGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-------------PiglaggLNLYAYVGNNPV 1017
|
...
gi 688587156 2481 SNS 2483
Cdd:COG3209 1018 NYV 1020
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1251-1519 |
1.95e-19 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 92.21 E-value: 1.95e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1251 GLADGN----KLLAPVALACGSDGSLYVGD-FNY-VRRIFTTGNVTSV---------LELSNSPAHKYY---LATSPvSG 1312
Cdd:cd14953 65 GFADGGgaaaQFNTPSGVAVDAAGNLYVADtGNHrIRKITPDGVVSTLagtgtagfsDDGGATAAQFNYptgVAVDA-AG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1313 WLYLSDTSSRKVFKVkslyavkDVAKNLELVAGTGdqclpydETRCGDGGKAVEATLTNPRGITVDKYGVIFFVD--GTM 1390
Cdd:cd14953 144 NLYVADTGNHRIRKI-------TPDGVVTTVAGTG-------GAGYAGDGPATAAQFNNPTGVAVDAAGNLYVADrgNHR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1391 IRRIDQNGIISTLLG-----FNDLTSArplscdsvmdiSQVRLEWPTDLAVSPMDNsLYVLD--NNVVLQISENHQVRIV 1463
Cdd:cd14953 210 IRKITPDGVVTTVAGtgtagFSGDGGA-----------TAAQLNNPTGVAVDAAGN-LYVADsgNHRIRKITPAGVVTTV 277
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 688587156 1464 AGRPmhcqvPGLDHFLVSKIAihATLESANALAVSHNGLLYIAESDEkkiNRVRQV 1519
Cdd:cd14953 278 AGGG-----AGFSGDGGPATS--AQFNNPTGVAVDAAGNLYVADTGN---NRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1369-1592 |
2.38e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 72.74 E-value: 2.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1369 LTNPRGITVDKYGVIFFVDGTM--IRRIDQNGIISTL---LGFNDltsarplscdsvmdisqVRLEWPTDLAVSPmDNSL 1443
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSfgsFGSGD-----------------GQFNEPAGVAVDS-DGNL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1444 YVLD--NNVVLQISENHQVRIVAGRPMHcQVPGLDHflvskiaihatlesANALAVSHNGLLYIAESDEkkiNRVRQVST 1521
Cdd:cd05819 69 YVADtgNHRIQKFDPDGNFLASFGGSGD-GDGEFNG--------------PRGIAVDSSGNIYVADTGN---HRIQKFDP 130
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688587156 1522 NGEISLLAGAPSGCdckndancdcysgddgyakDAKLNAPSSLAVSPDGELFIADLGNIRIRYVRRNKAFL 1592
Cdd:cd05819 131 DGEFLTTFGSGGSG-------------------PGQFNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFL 182
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1311-1594 |
2.89e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 72.74 E-value: 2.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1311 SGWLYLSDTSSRKVFKVkslyavkDVAKNLELVAGTGdqclpydetrcGDGGKaveaTLTNPRGITVDKYGVIFFVDGT- 1389
Cdd:cd05819 18 SGNIYVADTGNNRIQVF-------DPDGNFITSFGSF-----------GSGDG----QFNEPAGVAVDSDGNLYVADTGn 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1390 -MIRRIDQNGIISTLLGFNDLTsarplscdsvmdisQVRLEWPTDLAVSPMDNsLYVLDnnvvlqiSENHQVRIVA--GR 1466
Cdd:cd05819 76 hRIQKFDPDGNFLASFGGSGDG--------------DGEFNGPRGIAVDSSGN-IYVAD-------TGNHRIQKFDpdGE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1467 PMHCqvpgldhfLVSKIAIHATLESANALAVSHNGLLYIAESDEkkiNRVRQVSTNGEISLLAGapsgcdckndancdcy 1546
Cdd:cd05819 134 FLTT--------FGSGGSGPGQFNGPTGVAVDSDGNIYVADTGN---HRIQVFDPDGNFLTTFG---------------- 186
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 688587156 1547 sgdDGYAKDAKLNAPSSLAVSPDGELFIADLGNIRIRYVRRNKAFLNP 1594
Cdd:cd05819 187 ---STGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGG 231
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1248-1454 |
3.96e-13 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 72.95 E-value: 3.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1248 SCNGLADGNKLLAPVALACGSDGSLYVGDF--NYVRRIFTTGNVTSvlelsnspahkyylatspvsgwlylsdtssrkvf 1325
Cdd:cd14953 176 AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTT---------------------------------- 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1326 kvkslyavkdvaknlelVAGTGDQclPYdetrcGDGGKAVEATLTNPRGITVDKYGVIFFVD---GTmIRRIDQNGIIST 1402
Cdd:cd14953 222 -----------------VAGTGTA--GF-----SGDGGATAAQLNNPTGVAVDAAGNLYVADsgnHR-IRKITPAGVVTT 276
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688587156 1403 LL-------GFNDLTSArplscdsvmdisqVRLEWPTDLAVSPmDNSLYVLD--NNVVLQI 1454
Cdd:cd14953 277 VAgggagfsGDGGPATS-------------AQFNNPTGVAVDA-AGNLYVADtgNNRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1256-1585 |
1.32e-12 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 70.81 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1256 NKLLAPVALACGSDGSLYVGDF--NYVRR-------IFTTGNVTSVLELSNSPAHkyyLATSPvSGWLYLSDTSSRKVFK 1326
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTgnNRIQVfdpdgnfITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGNHRIQK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1327 VkslyavkDVAKNLELVAGTGDQclpydetrcGDGGkaveatLTNPRGITVDKYGVIFFVDgTM---IRRIDQNGIISTL 1403
Cdd:cd05819 81 F-------DPDGNFLASFGGSGD---------GDGE------FNGPRGIAVDSSGNIYVAD-TGnhrIQKFDPDGEFLTT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1404 LGFNDLTSArplscdsvmdisqvRLEWPTDLAVSPmDNSLYVLDnnvvlqiSENHQVRIVAgrpmhcqvPGlDHFLV--- 1480
Cdd:cd05819 138 FGSGGSGPG--------------QFNGPTGVAVDS-DGNIYVAD-------TGNHRIQVFD--------PD-GNFLTtfg 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1481 SKIAIHATLESANALAVSHNGLLYIAESDEkkiNRVRQVSTNGeislLAGAPSGcdckndancdcysgdDGYAKDAKLNA 1560
Cdd:cd05819 187 STGTGPGQFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDG----AGFGGNG---------------NFLGSDGQFNR 244
|
330 340
....*....|....*....|....*
gi 688587156 1561 PSSLAVSPDGELFIADLGNIRIRYV 1585
Cdd:cd05819 245 PSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1484-1585 |
2.36e-12 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 70.64 E-value: 2.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1484 AIHATLESANALAVSHNGLLYIAESDEkkiNRVRQVSTNGEISLLAGA-PSGcdckndancdcYSGDDGYAkdAKLNAPS 1562
Cdd:cd14953 17 GTAARFNSPSGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTgTAG-----------FADGGGAA--AQFNTPS 80
|
90 100
....*....|....*....|...
gi 688587156 1563 SLAVSPDGELFIADLGNIRIRYV 1585
Cdd:cd14953 81 GVAVDAAGNLYVADTGNHRIRKI 103
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
862-892 |
3.15e-11 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 59.84 E-value: 3.15e-11
10 20 30
....*....|....*....|....*....|.
gi 688587156 862 SMETACSDGKDNDGDGLTDCMDPDCCLQASC 892
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1254-1516 |
3.53e-10 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 63.49 E-value: 3.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1254 DGNKLLAPVALACGSDGSLYVGDF------------NYVRRIFTTGNVTSVLelsNSPahkYYLATSPvSGWLYLSDTSS 1321
Cdd:cd05819 50 GDGQFNEPAGVAVDSDGNLYVADTgnhriqkfdpdgNFLASFGGSGDGDGEF---NGP---RGIAVDS-SGNIYVADTGN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1322 RKVFKVKSlyavkdvakNLELVAGTGdqclpydetrcgdGGKAVEATLTNPRGITVDKYGVIFFVDGT--MIRRIDQNGI 1399
Cdd:cd05819 123 HRIQKFDP---------DGEFLTTFG-------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1400 ISTLLGFNDLTSArplscdsvmdisqvRLEWPTDLAVSPMDNsLYVLD--NNVVLQISENHQVRIVAGrpmhcqvpgldh 1477
Cdd:cd05819 181 FLTTFGSTGTGPG--------------QFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG------------ 233
|
250 260 270
....*....|....*....|....*....|....*....
gi 688587156 1478 flvSKIAIHATLESANALAVSHNGLLYIAESDEKKINRV 1516
Cdd:cd05819 234 ---NFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2405-2483 |
3.16e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.58 E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 2405 TAFGEVyLDSNPSFQLVIGYQGGLYEPLTKLVHMGRRDYDVLAGRWTTPDhdiwkrlnsdnivPF------NLYMFKNNN 2478
Cdd:TIGR03696 2 DPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGNN 67
|
....*
gi 688587156 2479 PLSNS 2483
Cdd:TIGR03696 68 PVNWV 72
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
602-886 |
6.19e-08 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 56.55 E-value: 6.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 602 DDCPSNCFGNGDCVSGNCH--------------CFPGFRGPDCSRASCpvlCSGngqylkgrCMCHSGwkgSECDVPTNQ 667
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASC---CGG--------VTCGAG---QTCDAKTNT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 668 CIDIT--CSGHGTCIVG--------TCICNPGYKGEnceevdcldptcSGRGvCVRGechcFVGWggpgcesprASCMEQ 737
Cdd:pfam19232 76 CVYVKgyCSADHPCPSGsacdtaknACIAQPPYGPD------------SGKG-CVRG----FGAW---------IWELDP 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 738 CSGHGSFladtnTCNCDHNW---TGHDCS----TELCAADCGGHGICVAGS---CRCDEGWmgtgceqrACHPRCSEHGT 807
Cdd:pfam19232 130 ATNSGVW-----RCRCANGSlynSAHECSpladQTLCAAENLDPNALVPASsvpAFAAYGW--------GNQPVLINKST 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 808 CKD-------GKCECSPGWNGEHCTIEGCpglCNGNGRCTLGNNGwyCVCQLGWRGAGcdtsmetacSDGKDNdgdGLTD 880
Cdd:pfam19232 197 AGAavpsplaGVCPCKPGWAGGSCTEDRT---CNGRGTWNETTGQ--CACNIDFSGHN---------SCGDDN---NCTS 259
|
....*.
gi 688587156 881 CMDPDC 886
Cdd:pfam19232 260 WTGPRC 265
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1261-1583 |
1.33e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 52.71 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1261 PVALACGSDGSLYVGDF--NYVRRI-FTTGNVTSVLELSNSPAHKyyLATSPvSGWLYLSDTSSRKVFKVkslyavkDVA 1337
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLdPATGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI-------DPK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1338 -KNLELVAGTGDQCLPYdetrcgdggkaveatltnprGITVDKYGVIFFVDGT--MIRRID-QNGIISTLLGFndLTSAR 1413
Cdd:COG4257 89 tGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPLP--TGGAG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1414 plscdsvmdisqvrlewPTDLAVSPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgldhflVSKIAIHATLESAN 1493
Cdd:COG4257 147 -----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYALPTPGAGPR 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1494 ALAVSHNGLLYIAESDEkkiNRVRQVSTN-GEISLLAGAPSGcdckndancdcysgddgyakdaklNAPSSLAVSPDGEL 1572
Cdd:COG4257 192 GLAVDPDGNLWVADTGS---GRIGRFDPKtGTVTEYPLPGGG------------------------ARPYGVAVDGDGRV 244
|
330
....*....|.
gi 688587156 1573 FIADLGNIRIR 1583
Cdd:COG4257 245 WFAESGANRIV 255
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1261-1582 |
2.64e-06 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 51.44 E-value: 2.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1261 PVALACGSDGSLYVGDFNYVRrifttgnvtsVLEL---SNSPA--------HKYYLATSPvSGWLYLSDTSSRKVfkvks 1329
Cdd:cd14952 12 PGGVAVDAAGNVYVADSGNNR----------VLKLaagSTTQTvlpftglyQPQGVAVDA-AGTVYVTDFGNNRV----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1330 lyavkdvaknLELVAGTGDQC-LPYdetrcgdggkaveATLTNPRGITVDKYGVIFFVDGTMIR--RIDQNGIISTLLGF 1406
Cdd:cd14952 76 ----------LKLAAGSTTQTvLPF-------------TGLNDPTGVAVDAAGNVYVADTGNNRvlKLAAGSNTQTVLPF 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1407 NDLTSarplscdsvmdisqvrlewPTDLAVSPMDNsLYVLD--NNVVLQISenhqvrivAGRPMHCQVPgldhFlvskia 1484
Cdd:cd14952 133 TGLSN-------------------PDGVAVDGAGN-VYVTDtgNNRVLKLA--------AGSTTQTVLP----F------ 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1485 ihATLESANALAVSHNGLLYIAESDEkkiNRVRQvstngeisLLAGAP-------SGcdckndancdcysgddgyakdak 1557
Cdd:cd14952 175 --TGLNSPSGVAVDTAGNVYVTDHGN---NRVLK--------LAAGSTtptvlpfTG----------------------- 218
|
330 340
....*....|....*....|....*
gi 688587156 1558 LNAPSSLAVSPDGELFIADLGNIRI 1582
Cdd:cd14952 219 LNGPLGVAVDAAGNVYVADRGNDRV 243
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1261-1395 |
3.54e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 51.17 E-value: 3.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1261 PVALACGSDGSLYVGDF--NYVRRIFTTGNVTSVLELSNSPAHKYYLATSPvSGWLYLSDTSSRKVFKVKSlyavkdVAK 1338
Cdd:COG4257 147 PYGIAVDPDGNLWVTDFgaNAIGRIDPDTGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSGRIGRFDP------KTG 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 688587156 1339 NLELVAGTGDQCLPYdetrcgdggkaveatltnprGITVDKYGVIFFVDGT--MIRRID 1395
Cdd:COG4257 220 TVTEYPLPGGGARPY--------------------GVAVDGDGRVWFAESGanRIVRFD 258
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1498-1589 |
3.64e-06 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 52.93 E-value: 3.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1498 SHNGLLYIAESDEKKINRVRQVStnGEISLLAGAPSGcdckndancdcySGDDGYAKDAKLNAPSSLAVSPDGELFIADL 1577
Cdd:PLN02919 812 AKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA------------GFKDGKALKAQLSEPAGLALGENGRLFVADT 877
|
90
....*....|..
gi 688587156 1578 GNIRIRYVRRNK 1589
Cdd:PLN02919 878 NNSLIRYLDLNK 889
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
784-826 |
1.48e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 44.15 E-value: 1.48e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 688587156 784 CDEGWMGTGCEqRACHPRCSE--HGTC-KDGKCECSPGWNGEHCTI 826
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDK 45
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1496-1586 |
5.16e-05 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 47.96 E-value: 5.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1496 AVSHNGLLYIAESDEKKINRV----RQVSTngeislLAGapsgcdckndancdcySGDDGYA-KDAKLNAPSSLAVSPDG 1570
Cdd:cd14951 202 AALPDGSVYVADTYNHKIKRVdpatGEVST------LAG----------------TGKAGYKdLEAQFSEPSGLVVDGDG 259
|
90
....*....|....*.
gi 688587156 1571 ELFIADLGNIRIRYVR 1586
Cdd:cd14951 260 RLYVADTNNHRIRRLD 275
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1364-1583 |
9.11e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 46.94 E-value: 9.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1364 AVEATLTNPRGITVDKYGVIFFVD--GTMIRRID-QNGIISTllgfndltsarplscdsvmdISQVRLEWPTDLAVSPmD 1440
Cdd:COG4257 11 PVPAPGSGPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFTE--------------------YPLGGGSGPHGIAVDP-D 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1441 NSLYVLD--NNVVLQIS-ENHQVRIVAGrpmhcqvPGLDHFLvskiaihatlesaNALAVSHNGLLYIAESDekkINRVR 1517
Cdd:COG4257 70 GNLWFTDngNNRIGRIDpKTGEITTFAL-------PGGGSNP-------------HGIAFDPDGNLWFTDQG---GNRIG 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1518 QVST-NGEISLL-----AGAPSGCDCKND---------ANC-DCYSGDDG----YAKDAKLNAPSSLAVSPDGELFIADL 1577
Cdd:COG4257 127 RLDPaTGEVTEFplptgGAGPYGIAVDPDgnlwvtdfgANAiGRIDPDTGtlteYALPTPGAGPRGLAVDPDGNLWVADT 206
|
....*.
gi 688587156 1578 GNIRIR 1583
Cdd:COG4257 207 GSGRIG 212
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1700-1734 |
1.38e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 41.43 E-value: 1.38e-04
10 20 30
....*....|....*....|....*....|....*
gi 688587156 1700 SSGLLATKSNEDGWSTFYEYDNYGRLTNVTYPTGR 1734
Cdd:pfam05593 3 AAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
753-795 |
1.64e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 41.46 E-value: 1.64e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 688587156 753 CDHNWTGHDCSTeLCAA--DCGGHGICVA-GSCRCDEGWMGTGCEQ 795
Cdd:pfam01414 1 CDENYYGSTCSK-FCRPrdDKFGHYTCDAnGNKVCLPGWTGPYCDK 45
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1254-1526 |
1.80e-04 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 46.17 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1254 DGNKLLAPVALACGSDGSLYVGDF--NYVRRI-FTTGNVTSVlELSNSPAHKYYLATSPvSGWLYLSDTSSRKVFKVksl 1330
Cdd:COG4257 54 PLGGGSGPHGIAVDPDGNLWFTDNgnNRIGRIdPKTGEITTF-ALPGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRL--- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1331 yavkDVAKN--LELVAGTGDqclpydetrcgdggkaveatlTNPRGITVDKYGVIFFVD--GTMIRRID-QNGIISTLLG 1405
Cdd:COG4257 129 ----DPATGevTEFPLPTGG---------------------AGPYGIAVDPDGNLWVTDfgANAIGRIDpDTGTLTEYAL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1406 FNDLTSarplscdsvmdisqvrlewPTDLAVSPmDNSLYVLDnnvvlqiSENHQVRIVAgrpmhcqvPGLDHFlvSKIAI 1485
Cdd:COG4257 184 PTPGAG-------------------PRGLAVDP-DGNLWVAD-------TGSGRIGRFD--------PKTGTV--TEYPL 226
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 688587156 1486 HATLESANALAVSHNGLLYIAESDekkINRVRQVSTNGEIS 1526
Cdd:COG4257 227 PGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELT 264
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1257-1452 |
2.47e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 45.36 E-value: 2.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1257 KLLAPVALACGSDGSLYVGDFnYVRRI--FTT-GNVTSVLelsnspAHKYYL--ATSPV-----SGWLYLSDTSSRKVF- 1325
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFDPdGKFLKYF------PEKKDRvkLISPAglaidDGKLYVSDVKKHKVIv 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1326 ------KVKS----------LYAVKDVA---KNLELVAGTGDQ-CLPYDET----RCGDGGKAVEATLTNPRGITVDKYG 1381
Cdd:cd14963 127 fdlegkLLLEfgkpgsepgeLSYPNGIAvdeDGNIYVADSGNGrIQVFDKNgkfiKELNGSPDGKSGFVNPRGIAVDPDG 206
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688587156 1382 VIFFVDgTMIRRI---DQNGIISTLLGfndltsarplscdsVMDISQVRLEWPTDLAVSPmDNSLYVLD--NNVVL 1452
Cdd:cd14963 207 NLYVVD-NLSHRVyvfDEQGKELFTFG--------------GRGKDDGQFNLPNGLFIDD-DGRLYVTDreNNRVA 266
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1557-1651 |
3.31e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 44.97 E-value: 3.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1557 KLNAPSSLAVSPDGELFIADLGNIRIRYVRRNKAFLN----PLNMYEISSPI-----DDELYLFDVNASH--VFTQsltT 1625
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKFLKyfpeKKDRVKLISPAglaidDGKLYVSDVKKHKviVFDL---E 130
|
90 100 110
....*....|....*....|....*....|.
gi 688587156 1626 GDYLYNF--TYSGEGDLSS---ITDKNKNRV 1651
Cdd:cd14963 131 GKLLLEFgkPGSEPGELSYpngIAVDEDGNI 161
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
672-695 |
4.41e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.64 E-value: 4.41e-04
10 20
....*....|....*....|....*.
gi 688587156 672 TCSGHGTCIV--GTCICNPGYKGENC 695
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1252-1400 |
4.56e-04 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.88 E-value: 4.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1252 LAD--GNKLLAPVALACGSDGSLYVGDFNYVR------RIFTTGNVTSVLE---LSNSpahkyyLATSPVSGWLYLSDTS 1320
Cdd:COG3386 84 LADeyGKPLNRPNDGVVDPDGRLYFTDMGEYLptgalyRVDPDGSLRVLADgltFPNG------IAFSPDGRTLYVADTG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1321 SRKVFKVkslyavkDVAKNLELVAGTgdqclPYDETRCGDGGkaveatltnPRGITVDKYGVIF--FVDGTMIRRIDQNG 1398
Cdd:COG3386 158 AGRIYRF-------DLDADGTLGNRR-----VFADLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDG 216
|
..
gi 688587156 1399 II 1400
Cdd:COG3386 217 EL 218
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
802-824 |
1.01e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.01e-03
|
| DSL |
smart00051 |
delta serrate ligand; |
783-824 |
1.26e-03 |
|
delta serrate ligand;
Pssm-ID: 128366 Cd Length: 63 Bit Score: 39.24 E-value: 1.26e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 688587156 783 RCDEGWMGTGCE-------QRACHPRCSEHGtckdgKCECSPGWNGEHC 824
Cdd:smart00051 20 TCDENYYGEGCNkfcrprdDFFGHYTCDENG-----NKGCLEGWMGPYC 63
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
770-793 |
1.78e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.78e-03
10 20
....*....|....*....|....*.
gi 688587156 770 DCGGHGICVA--GSCRCDEGWMGTGC 793
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
673-696 |
1.97e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.97e-03
10 20
....*....|....*....|....*...
gi 688587156 673 CSGHGTCI--VG--TCICNPGYKGENCE 696
Cdd:cd00054 11 CQNGGTCVntVGsyRCSCPPGYTGRNCE 38
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
695-867 |
2.79e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 40.93 E-value: 2.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 695 CEEVDCLDPTCSGRGVCvrGECHCFVGWGGPGCESPrASCMEQCSGHGSFLADTNTCNCDHNwtghdCSTELCAADCGGH 774
Cdd:pfam01500 4 CGTSFCGFPTCSTGGTC--GSGCCQPCCCQSSCCRP-SCCQTSCCQPTTFQSSCCRPTCQPC-----CQTSCCQPTCCQT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 775 GICVAGSCRCDEGWMG----TGCEQRACHPRCSEHGTCKDGKCECSpgwngehCTIEGCPGLCNGNGRCTLGNngwYCVc 850
Cdd:pfam01500 76 SSCQTGCGGIGYGQEGssgaVSSRTRWCRPDCRVEGTCLPPCCVVS-------CTPPTCCQLHHAQASCCRPS---YCG- 144
|
170
....*....|....*..
gi 688587156 851 QLGWRGAGCDTSMETAC 867
Cdd:pfam01500 145 QSCCRPACCCQCSEPTC 161
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1251-1582 |
3.78e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 41.88 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1251 GLADGnKLLAPVALACGSDGSLYVGD--------F----NYVRRIFTTGNVTSVLE-LSNSPAHKyylatspvSGWLYLS 1317
Cdd:cd14956 6 GSGPG-QFKDPRGIAVDADDNVYVADarngriqvFdkdgTFLRRFGTTGDGPGQFGrPRGLAVDK--------DGWLYVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1318 DTSSRKVfKVKSLyavkdvaknlelvAGTGDqclpydeTRCGDGGKAvEATLTNPRGITVDKYGVIFFVD--GTMIRRID 1395
Cdd:cd14956 77 DYWGDRI-QVFTL-------------TGELQ-------TIGGSSGSG-PGQFNAPRGVAVDADGNLYVADfgNQRIQKFD 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1396 QNGiiSTLLGFNDlTSARPLScdsvmdisqvrLEWPTDLAVSPmDNSLYVLDnnvvlqiSENHQVrivagrpmhcQVPGL 1475
Cdd:cd14956 135 PDG--SFLRQWGG-TGIEPGS-----------FNYPRGVAVDP-DGTLYVAD-------TYNDRI----------QVFDN 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688587156 1476 DHFLVSKIAIHAT----LESANALAVSHNGLLYIAESDEkkiNRVrQVSTNGEISLLA-GAPSGcdckndancdcysgdd 1550
Cdd:cd14956 183 DGAFLRKWGGRGTgpgqFNYPYGIAIDPDGNVFVADFGN---NRI-QKFTADGTFLTSwGSPGT---------------- 242
|
330 340 350
....*....|....*....|....*....|..
gi 688587156 1551 gyaKDAKLNAPSSLAVSPDGELFIADLGNIRI 1582
Cdd:cd14956 243 ---GPGQFKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
2293-2329 |
4.76e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.81 E-value: 4.76e-03
10 20 30
....*....|....*....|....*....|....*..
gi 688587156 2293 YNSAGLLVKTYNkVNGWTIKYRYDGLGRRVSSRSTQG 2329
Cdd:pfam05593 1 YDAAGRLTSVTD-PDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1698-1738 |
6.61e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 36.80 E-value: 6.61e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 688587156 1698 HGSSGLLATKSNEDGWSTFYEYDNYGRLTNVTYPTGRVSSY 1738
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
608-630 |
7.98e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.17 E-value: 7.98e-03
|
| |
