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Tmem108 transmembrane protein 108 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300967, updated on 4-Jan-2025

Summary

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Official Symbol
Tmem108provided by RGD
Official Full Name
transmembrane protein 108provided by RGD
Primary source
RGD:1311530
See related
EnsemblRapid:ENSRNOG00000010911 AllianceGenome:RGD:1311530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311530
Summary
Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in somatodendritic compartment. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynaptic density membrane. Orthologous to human TMEM108 (transmembrane protein 108). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 13.2), Adrenal (RPKM 9.2) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem108 in Genome Data Viewer
Location:
8q32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112944925..113238996, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (104066081..104360172, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111968568..112265623, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550226 Neighboring gene beaded filament structural protein 2 Neighboring gene uncharacterized LOC134480226 Neighboring gene uncharacterized LOC134480225 Neighboring gene uncharacterized LOC134480227 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 7 Neighboring gene uncharacterized LOC102550471 Neighboring gene uncharacterized LOC134479986

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus. Jiao HF, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096412, Free PMC Article
  2. Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth. Xu C, et al. Mol Biol Cell, 2016 Nov 1. PMID 27605705, Free PMC Article
  3. Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes. Fu X, et al. Mol Biol Cell, 2011 Oct. PMID 21849472, Free PMC Article
  4. Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Liu JJ, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17287360, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to brain-derived neurotrophic factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in dentate gyrus development ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic density organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic density organization ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde axonal transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399273.1 → NP_001386202.1  transmembrane protein 108 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I2K3, F1M8M1
    Conserved Domains (1) summary
    pfam15759
    Location:63 → 575
    TMEM108; TMEM108 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    112944925..113238996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082601.2 → XP_038938529.1  transmembrane protein 108 isoform X2

    UniProtKB/TrEMBL
    A6I2K3, F1M8M1
    Conserved Domains (1) summary
    pfam15759
    Location:63 → 575
    TMEM108; TMEM108 family

  2. XM_039082589.2 → XP_038938517.1  transmembrane protein 108 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALT4, A6I2K3
    Conserved Domains (1) summary
    pfam15759
    Location:95 → 607
    TMEM108; TMEM108 family

  3. XM_008766590.4 → XP_008764812.2  transmembrane protein 108 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALT4, A6I2K3
    Conserved Domains (1) summary
    pfam15759
    Location:95 → 607
    TMEM108; TMEM108 family

  4. XM_063265234.1 → XP_063121304.1  transmembrane protein 108 isoform X5

  5. XM_063265233.1 → XP_063121303.1  transmembrane protein 108 isoform X5

  6. XM_039082607.2 → XP_038938535.1  transmembrane protein 108 isoform X2

    UniProtKB/TrEMBL
    A6I2K3, F1M8M1
    Conserved Domains (1) summary
    pfam15759
    Location:63 → 575
    TMEM108; TMEM108 family

  7. XM_039082604.2 → XP_038938532.1  transmembrane protein 108 isoform X2

    UniProtKB/TrEMBL
    A6I2K3, F1M8M1
    Related
    ENSRNOP00000014520.9, ENSRNOT00000014519.9
    Conserved Domains (1) summary
    pfam15759
    Location:63 → 575
    TMEM108; TMEM108 family

  8. XM_039082592.2 → XP_038938520.1  transmembrane protein 108 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALT4, A6I2K3
    Conserved Domains (1) summary
    pfam15759
    Location:95 → 607
    TMEM108; TMEM108 family

  9. XM_063265236.1 → XP_063121306.1  transmembrane protein 108 isoform X5

  10. XM_039082593.2 → XP_038938521.1  transmembrane protein 108 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALT4, A6I2K3
    Conserved Domains (1) summary
    pfam15759
    Location:95 → 607
    TMEM108; TMEM108 family

  11. XM_039082605.2 → XP_038938533.1  transmembrane protein 108 isoform X2

    UniProtKB/TrEMBL
    A6I2K3, F1M8M1
    Conserved Domains (1) summary
    pfam15759
    Location:63 → 575
    TMEM108; TMEM108 family

  12. XM_039082594.2 → XP_038938522.1  transmembrane protein 108 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALT4, A6I2K3
    Conserved Domains (1) summary
    pfam15759
    Location:95 → 607
    TMEM108; TMEM108 family

  13. XM_039082590.2 → XP_038938518.1  transmembrane protein 108 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALT4, A6I2K3
    Conserved Domains (1) summary
    pfam15759
    Location:95 → 607
    TMEM108; TMEM108 family

  14. XM_039082606.2 → XP_038938534.1  transmembrane protein 108 isoform X2

    UniProtKB/TrEMBL
    A6I2K3, F1M8M1
    Conserved Domains (1) summary
    pfam15759
    Location:63 → 575
    TMEM108; TMEM108 family

  15. XM_039082603.2 → XP_038938531.1  transmembrane protein 108 isoform X2

    UniProtKB/TrEMBL
    A6I2K3, F1M8M1
    Conserved Domains (1) summary
    pfam15759
    Location:63 → 575
    TMEM108; TMEM108 family

  16. XM_063265235.1 → XP_063121305.1  transmembrane protein 108 isoform X5

  17. XM_063265232.1 → XP_063121302.1  transmembrane protein 108 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GI14, A6I2K3
    Related
    ENSRNOP00000094794.2, ENSRNOT00000104880.2

  18. XM_063265231.1 → XP_063121301.1  transmembrane protein 108 isoform X3

    UniProtKB/TrEMBL
    A6I2K3
Nucleotide Protein Strain
Heading Accession and Version

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