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Nin ninein [ Rattus norvegicus (Norway rat) ]

Gene ID: 299117, updated on 27-Nov-2024

Summary

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Symbol
Ninprovided by RGD
Full Name
nineinprovided by RGD
Primary source
RGD:1306492
See related
EnsemblRapid:ENSRNOG00000005540 AllianceGenome:RGD:1306492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable microtubule minus-end binding activity. Predicted to be involved in centrosome localization; microtubule cytoskeleton organization; and protein localization. Predicted to act upstream of or within axonogenesis and positive regulation of axonogenesis. Predicted to be located in several cellular components, including axonal growth cone; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of centriolar subdistal appendage and ciliary transition fiber. Predicted to be active in centriole; mitotic spindle pole; and pericentriolar material. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Orthologous to human NIN (ninein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 147.7), Spleen (RPKM 142.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nin in Genome Data Viewer
Location:
6q24
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (94261382..94363679, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88525405..88627710, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92423412..92527776, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene salvador family WW domain containing protein 1 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 5 Neighboring gene abhydrolase domain containing 12B Neighboring gene glycogen phosphorylase L Neighboring gene uncharacterized LOC134479216

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Wang X, et al. Nature, 2009 Oct 15. PMID 19829375, Free PMC Article
  2. Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: the role of ninein. Mogensen MM, et al. J Cell Sci, 2000 Sep. PMID 10934040
  3. Molecular characterisation of ninein, a new coiled-coil protein of the centrosome. Bouckson-Castaing V, et al. J Cell Sci, 1996 Jan. PMID 8834802
  4. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. Howng SL, et al. FEBS Lett, 2004 May 21. PMID 15147888
  5. Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function. Delgehyr N, et al. J Cell Sci, 2005 Apr 15. PMID 15784680

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule minus-end binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in centriole-centriole cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within centrosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome-templated microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within centrosome-templated microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within collateral sprouting ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within corpus callosum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within corticospinal tract morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule anchoring at centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule anchoring at centrosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
part_of centriolar subdistal appendage ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of ciliary transition fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ciliary transition fiber ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in pericentriolar material IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ninein
Names
ninein (GSK3B interacting protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106737.1 → NP_001100207.1  ninein isoform 1

    See identical proteins and their annotated locations for NP_001100207.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A0A8I6A7B7, A6HBY6
    Conserved Domains (5) summary
    COG1196
    Location:698 → 1573
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16269
    Location:792 → 803
    GBP_C; coiled coil [structural motif]
    cl00459
    Location:377 → 552
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:475 → 567
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:709 → 821
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001434244.1 → NP_001421173.1  ninein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001434245.1 → NP_001421174.1  ninein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    94261382..94363679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594089.3 → XP_017449578.1  ninein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7B7
    Conserved Domains (3) summary
    COG1196
    Location:1433 → 1672
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:388 → 981
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:1045 → 1998
    CCDC158; Coiled-coil domain-containing protein 158

  2. XM_008764706.4 → XP_008762928.1  ninein isoform X4

    UniProtKB/TrEMBL
    A0A8I6A7B7
    Conserved Domains (5) summary
    COG1196
    Location:698 → 1573
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16269
    Location:792 → 803
    GBP_C; coiled coil [structural motif]
    cl00459
    Location:377 → 552
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:475 → 567
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:709 → 821
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. XM_008764705.4 → XP_008762927.1  ninein isoform X3

    UniProtKB/TrEMBL
    A0A8I6A538, A0A8I6A7B7
    Related
    ENSRNOP00000088832.2, ENSRNOT00000108786.2
    Conserved Domains (5) summary
    COG1196
    Location:698 → 1573
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:358 → 951
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd16269
    Location:792 → 803
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:475 → 567
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:709 → 821
    GBP_C; Guanylate-binding protein, C-terminal domain

  4. XM_063261705.1 → XP_063117775.1  ninein isoform X2

  5. XM_006240158.5 → XP_006240220.1  ninein isoform X1

    See identical proteins and their annotated locations for XP_006240220.1

    UniProtKB/TrEMBL
    A0A8I6A7B7
    Conserved Domains (3) summary
    COG1196
    Location:1433 → 1672
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:388 → 981
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:1045 → 1998
    CCDC158; Coiled-coil domain-containing protein 158

  6. XM_039111992.2 → XP_038967920.1  ninein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7B7
    Conserved Domains (3) summary
    COG1196
    Location:1433 → 1672
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:388 → 981
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:1045 → 1998
    CCDC158; Coiled-coil domain-containing protein 158

  7. XM_063261708.1 → XP_063117778.1  ninein isoform X13

  8. XM_008764710.4 → XP_008762932.1  ninein isoform X14

    Conserved Domains (5) summary
    TIGR02168
    Location:354 → 1103
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd16269
    Location:792 → 803
    GBP_C; coiled coil [structural motif]
    cl00459
    Location:377 → 552
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:475 → 567
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:709 → 821
    GBP_C; Guanylate-binding protein, C-terminal domain

  9. XM_039111994.2 → XP_038967922.1  ninein isoform X12

    UniProtKB/TrEMBL
    A0A8I6A5C4
    Conserved Domains (2) summary
    PRK01156
    Location:833 → 1433
    PRK01156; chromosome segregation protein; Provisional
    TIGR02168
    Location:384 → 1128
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  10. XM_063261706.1 → XP_063117776.1  ninein isoform X6

  11. XM_008764707.4 → XP_008762929.1  ninein isoform X5

    UniProtKB/TrEMBL
    A0A8I6A7B7
    Conserved Domains (6) summary
    COG1196
    Location:728 → 1603
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04523
    Location:1533 → 1985
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    cd16269
    Location:822 → 833
    GBP_C; coiled coil [structural motif]
    cl00459
    Location:407 → 582
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:505 → 597
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:739 → 851
    GBP_C; Guanylate-binding protein, C-terminal domain

  12. XM_008764708.4 → XP_008762930.1  ninein isoform X7

    UniProtKB/TrEMBL
    A0A8I6A7B7, D4A1J7
    Related
    ENSRNOP00000007529.5, ENSRNOT00000007529.6
    Conserved Domains (6) summary
    COG1196
    Location:698 → 1573
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04523
    Location:1503 → 1955
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    cd16269
    Location:792 → 803
    GBP_C; coiled coil [structural motif]
    cl00459
    Location:377 → 552
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:475 → 567
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:709 → 821
    GBP_C; Guanylate-binding protein, C-terminal domain

  13. XM_063261709.1 → XP_063117779.1  ninein isoform X15

    Related
    ENSRNOP00000086179.2, ENSRNOT00000112425.2

  14. XM_017594090.3 → XP_017449579.1  ninein isoform X10

    UniProtKB/TrEMBL
    A0A8I6A7B7

  15. XM_008764709.4 → XP_008762931.1  ninein isoform X8

    UniProtKB/TrEMBL
    A0A8I6A7B7
    Related
    ENSRNOP00000044897.7, ENSRNOT00000052408.7
    Conserved Domains (6) summary
    COG1196
    Location:728 → 1603
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04523
    Location:1533 → 1984
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    cd16269
    Location:822 → 833
    GBP_C; coiled coil [structural motif]
    cl00459
    Location:407 → 582
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:505 → 597
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:739 → 851
    GBP_C; Guanylate-binding protein, C-terminal domain

  16. XM_017594091.3 → XP_017449580.1  ninein isoform X11

    UniProtKB/TrEMBL
    A0A8I6A7B7

  17. XM_039111993.2 → XP_038967921.1  ninein isoform X9

    UniProtKB/TrEMBL
    A0A8I6A7B7
    Conserved Domains (3) summary
    COG1196
    Location:1433 → 1672
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:388 → 981
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:1045 → 1982
    CCDC158; Coiled-coil domain-containing protein 158
Nucleotide Protein Strain
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