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Argp Arginine phosphatase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 261628, updated on 4-Jan-2025

Summary

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Official Symbol
Argpprovided by FlyBase
Official Full Name
Arginine phosphataseprovided by FlyBase
Primary source
FLYBASE:FBgn0051469
Locus tag
Dmel_CG31469
See related
AllianceGenome:FB:FBgn0051469
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31469; CG9599; DARP; Dmel\CG31469
Summary
Enables protein arginine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoplasm and extracellular exosome. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Argp in Genome Data Viewer
Location:
87F12-87F12; 3-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13709159..13709939, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9534881..9535661, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene neither inactivation nor afterpotential B Neighboring gene Adenosine deaminase-related growth factor D Neighboring gene Adenosine deaminase-related growth factor C Neighboring gene primo-1 Neighboring gene primo-2 Neighboring gene long non-coding RNA:CR34044

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria. Fuhrmann J, et al. Cell Rep, 2013 Jun 27. PMID 23770242
  2. Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1. Lee HS, et al. Mol Cells, 2020 Dec 31. PMID 33372666, Free PMC Article
  3. The Recent De Novo Origin of Protein C-Termini. Andreatta ME, et al. Genome Biol Evol, 2015 May 21. PMID 26002864, Free PMC Article
  4. A Drosophila-centric view of protein tyrosine phosphatases. Hatzihristidis T, et al. FEBS Lett, 2015 Apr 13. PMID 25771859
  5. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. Lai CQ, et al. Mech Ageing Dev, 2007 Mar. PMID 17196240

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein arginine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables protein tyrosine phosphatase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular exosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
arginine phosphatase
Names
Argp-PA
CG31469-PA
drosophila ARginine phosphatase
NP_731853.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13709159..13709939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169551.4 → NP_731853.2  arginine phosphatase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731853.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V6G0, Q4V6L6, Q8ING6
    Conserved Domains (1) summary
    cd00115
    Location:1 → 151
    LMWPc; Low molecular weight phosphatase family;
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8ING6 Q8ING6

Gene LinkOut

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