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Cstl1 cystatin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 228756, updated on 27-Nov-2024

Summary

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Official Symbol
Cstl1provided by MGI
Official Full Name
cystatin-like 1provided by MGI
Primary source
MGI:MGI:2652834
See related
Ensembl:ENSMUSG00000055177 AllianceGenome:MGI:2652834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RCET1; RCET2; RCET3
Summary
Enables cysteine-type peptidase activity. Involved in signaling receptor ligand precursor processing. Predicted to be located in extracellular region. Is expressed in testis. Orthologous to human CSTL1 (cystatin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 37.1) See more
Orthologs
human all
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Genomic context

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See Cstl1 in Genome Data Viewer
Location:
2 G3; 2 73.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148592272..148597354)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148750361..148755434)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:148506639-148506940 Neighboring gene predicted gene, 46771 Neighboring gene GDNF-inducible zinc finger protein 1 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein beta Neighboring gene predicted gene, 54122 Neighboring gene STARR-positive B cell enhancer ABC_E9206 Neighboring gene cystatin 11 Neighboring gene STARR-seq mESC enhancer starr_05977 Neighboring gene cystatin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning, characterization and identification of Rcet1-v1 and Rcet1-v2, two novel splice variants of mouse Rcet1 related to Cres subgroup of family 2 cystatins. Xiang Y, et al. DNA Seq, 2008 Feb. PMID 18300157
  2. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Yasothornsrikul S, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12869695, Free PMC Article
  3. A new subgroup of the family 2 cystatins. Cornwall GA, et al. Mol Cell Endocrinol, 2003 Feb 28. PMID 12644294
  4. The reproductive tissue specific cystatin subgroup of genes: expression during gonadal development in wildtype and testatin knockout animals. Frygelius J, et al. Sex Dev, 2007. PMID 18391548
  5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Primarily expressed in mouse male reproductive tract; may play important roles in mouse spermatocyte and spermatid development.
    Title: Cloning, characterization and identification of Rcet1-v1 and Rcet1-v2, two novel splice variants of mouse Rcet1 related to Cres subgroup of family 2 cystatins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC58781

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in signaling receptor ligand precursor processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signaling receptor ligand precursor processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cystatin-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362207.1 → NP_001349136.1  cystatin-like 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844519
    Consensus CDS
    CCDS89564.1
    UniProtKB/TrEMBL
    A0A2Q2AAE3
    Related
    ENSMUSP00000105580.2, ENSMUST00000109954.8
    Conserved Domains (1) summary
    cl09238
    Location:28 → 86
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

  2. NM_177655.4 → NP_808323.1  cystatin-like 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_808323.1

    Status: VALIDATED

    Source sequence(s)
    AL844519
    Consensus CDS
    CCDS16844.1
    UniProtKB/Swiss-Prot
    Q3V2I7, Q64FK4, Q64FK5, Q80Y72
    Related
    ENSMUSP00000105581.4, ENSMUST00000109955.10
    Conserved Domains (1) summary
    smart00043
    Location:32 → 138
    CY; Cystatin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    148592272..148597354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499302.2 → XP_006499365.1  cystatin-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006499365.1

    UniProtKB/Swiss-Prot
    Q3V2I7, Q64FK4, Q64FK5, Q80Y72
    Conserved Domains (1) summary
    smart00043
    Location:32 → 138
    CY; Cystatin-like domain

  2. XM_006499303.3 → XP_006499366.1  cystatin-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006499366.1

    UniProtKB/Swiss-Prot
    Q3V2I7, Q64FK4, Q64FK5, Q80Y72
    Related
    ENSMUSP00000105578.2, ENSMUST00000109952.2
    Conserved Domains (1) summary
    smart00043
    Location:32 → 138
    CY; Cystatin-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80Y72.1 GenPept UniProtKB/Swiss-Prot:Q80Y72

Gene LinkOut

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