NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1375456830|ref|NP_001349136|]
View 

cystatin-like 1 isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-86 6.18e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 45.88  E-value: 6.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1375456830   28 GVEYLVTVKIGRTKCKKNETKKASCPLQSSklkKSLICKSLIYSVPWMNYYQLWNNSCQ 86
Cdd:smart00043  52 GTNYYLKVEVGETNCKKLSVDLENCPFLDQ---GEKFCTAKVWEKPWENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-86 6.18e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 45.88  E-value: 6.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1375456830   28 GVEYLVTVKIGRTKCKKNETKKASCPLQSSklkKSLICKSLIYSVPWMNYYQLWNNSCQ 86
Cdd:smart00043  52 GTNYYLKVEVGETNCKKLSVDLENCPFLDQ---GEKFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-85 8.57e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 43.23  E-value: 8.57e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1375456830  28 GVEYLVTVKIGRTKCKKNETKKASCPLQSSKLKKSLICKSLIYSVPWMNYYQLWNNSC 85
Cdd:cd00042    48 GTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 28-74 4.66e-06

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 40.78  E-value: 4.66e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 1375456830 28 GVEYLVTVKIGRTKCKKNETKKASCPLQssKLKKSLICKSLIYSVPW 74
Cdd:pfam00031 48 GTNYFIKVEVGETDCSKSKKLLEDCPLL--DEKWLGLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-86 6.18e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 45.88  E-value: 6.18e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1375456830   28 GVEYLVTVKIGRTKCKKNETKKASCPLQSSklkKSLICKSLIYSVPWMNYYQLWNNSCQ 86
Cdd:smart00043  52 GTNYYLKVEVGETNCKKLSVDLENCPFLDQ---GEKFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-85 8.57e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 43.23  E-value: 8.57e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1375456830  28 GVEYLVTVKIGRTKCKKNETKKASCPLQSSKLKKSLICKSLIYSVPWMNYYQLWNNSC 85
Cdd:cd00042    48 GTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 28-74 4.66e-06

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 40.78  E-value: 4.66e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 1375456830 28 GVEYLVTVKIGRTKCKKNETKKASCPLQssKLKKSLICKSLIYSVPW 74
Cdd:pfam00031 48 GTNYFIKVEVGETDCSKSKKLLEDCPLL--DEKWLGLCSAQVYKVPW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH