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Fmo4 flavin containing monooxygenase 4 [ Mus musculus (house mouse) ]

Gene ID: 226564, updated on 27-Nov-2024

Summary

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Official Symbol
Fmo4provided by MGI
Official Full Name
flavin containing monooxygenase 4provided by MGI
Primary source
MGI:MGI:2429497
See related
Ensembl:ENSMUSG00000026692 AllianceGenome:MGI:2429497
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Ertd532e
Summary
Predicted to enable N,N-dimethylaniline monooxygenase activity. Acts upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and xenobiotic catabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FMO4 (flavin containing dimethylaniline monoxygenase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 10.1), large intestine adult (RPKM 5.6) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Fmo4 in Genome Data Viewer
Location:
1 H2.1; 1 70.34 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162620757..162643788, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162793188..162816072, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene myocilin Neighboring gene myocilin opposite strand Neighboring gene proline-rich coiled-coil 2C Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:164658175-164658482 Neighboring gene STARR-positive B cell enhancer ABC_E1234 Neighboring gene STARR-seq mESC enhancer starr_02843 Neighboring gene STARR-seq mESC enhancer starr_02844 Neighboring gene STARR-seq mESC enhancer starr_02845 Neighboring gene VISTA enhancer mm713 Neighboring gene STARR-seq mESC enhancer starr_02846 Neighboring gene flavin containing monooxygenase 1 Neighboring gene predicted gene, 32197

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance. Veeravalli S, et al. Biochem Pharmacol, 2014 Jul 1. PMID 24792439
  2. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. Novick RM, et al. J Pharmacol Exp Ther, 2009 Jun. PMID 19307449, Free PMC Article
  3. Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. Veeravalli S, et al. Drug Metab Dispos, 2020 May. PMID 32156684
  4. Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine. Hernandez D, et al. Pharmacogenet Genomics, 2009 Apr. PMID 19262426
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT).
    Title: The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.
  2. Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes.
    Title: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124273, MGC124274

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N,N-dimethylaniline monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within energy homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fatty acid oxidation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within xenobiotic catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dimethylaniline monooxygenase [N-oxide-forming] 4
Names
FMO 4
dimethylaniline oxidase 4
hepatic flavin-containing monooxygenase 4
NP_659127.1
XP_006496836.1
XP_006496837.1
XP_006496838.1
XP_006496839.1
XP_006496840.1
XP_030109252.1
XP_030109253.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144878.1 → NP_659127.1  dimethylaniline monooxygenase [N-oxide-forming] 4

    See identical proteins and their annotated locations for NP_659127.1

    Status: PROVISIONAL

    Source sequence(s)
    AF461145
    Consensus CDS
    CCDS15423.1
    UniProtKB/Swiss-Prot
    Q8VHG0
    UniProtKB/TrEMBL
    Q3KP75
    Related
    ENSMUSP00000028014.4, ENSMUST00000028014.10
    Conserved Domains (1) summary
    pfam00743
    Location:2 → 531
    FMO-like; Flavin-binding monooxygenase-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    162620757..162643788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496776.4 → XP_006496839.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X2

    See identical proteins and their annotated locations for XP_006496839.1

    UniProtKB/Swiss-Prot
    Q8VHG0
    UniProtKB/TrEMBL
    Q3KP75
    Conserved Domains (1) summary
    pfam00743
    Location:2 → 531
    FMO-like; Flavin-binding monooxygenase-like

  2. XM_006496773.3 → XP_006496836.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

    See identical proteins and their annotated locations for XP_006496836.1

    UniProtKB/TrEMBL
    Q3KP75
    Conserved Domains (1) summary
    pfam00743
    Location:23 → 552
    FMO-like; Flavin-binding monooxygenase-like

  3. XM_006496777.3 → XP_006496840.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X2

    See identical proteins and their annotated locations for XP_006496840.1

    UniProtKB/Swiss-Prot
    Q8VHG0
    UniProtKB/TrEMBL
    Q3KP75
    Related
    ENSMUSP00000107150.2, ENSMUST00000111525.8
    Conserved Domains (1) summary
    pfam00743
    Location:2 → 531
    FMO-like; Flavin-binding monooxygenase-like

  4. XM_006496774.3 → XP_006496837.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

    See identical proteins and their annotated locations for XP_006496837.1

    UniProtKB/TrEMBL
    Q3KP75
    Conserved Domains (1) summary
    pfam00743
    Location:23 → 552
    FMO-like; Flavin-binding monooxygenase-like

  5. XM_006496775.4 → XP_006496838.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

    See identical proteins and their annotated locations for XP_006496838.1

    UniProtKB/TrEMBL
    Q3KP75
    Conserved Domains (1) summary
    pfam00743
    Location:23 → 552
    FMO-like; Flavin-binding monooxygenase-like

  6. XM_030253393.2 → XP_030109253.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X4

    Conserved Domains (1) summary
    pfam00743
    Location:2 → 163
    FMO-like; Flavin-binding monooxygenase-like

  7. XM_030253392.2 → XP_030109252.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X3

    Conserved Domains (1) summary
    pfam00743
    Location:23 → 184
    FMO-like; Flavin-binding monooxygenase-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHG0.3 GenPept UniProtKB/Swiss-Prot:Q8VHG0

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