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Conserved domains on  [gi|568910718|ref|XP_006496840|]
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dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X2 [Mus musculus]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-530 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 896.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718    2 AKKVAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFADTSEDGMTRVYRSLVTNVCKEMSCYSDFPFREDYPNF 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   82 MSHEKFWDYLREFAEHFGLLRYIRFKTTVLSVTKRPDFSETGQWDVVTETEGKRDRAVFDAVMVCTGQFLSPHLPLESFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  162 GIHKFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTGTWVLSRSSPGGYPFNMI-QTRWLN 240
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLfSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  241 FLVRVLPSRFINWTHERKMNKILNHENYGLSIAKGKKPK-FIVNDELPTCILCGKVTMKTSVKDFTESSVIFEDGTTEAN 319
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKePVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  320 IDVVIFTTGYEFSFPFFEEPLKSLCTKKIILYKRVFPPNLERATLAIIGLISLNGSILVGTEFQARWATRVFKGLCSIPP 399
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  400 SQKLMAEATK-TEQLIKRGVIKDTSQDKLDFITYMDELTQCIGAKPSIPLLFIKDPRLAWEVFFGPCTPYQYRLVGPGRW 478
Cdd:pfam00743 401 QSEMMAEINKrQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568910718  479 DGARNAILTQWDRTLKPLKTRIVPKSPEPTSlSHYLIAWGAPVLLVSLLLIY 530
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPAS-SFTLKIFGLPVVLVAIFLIL 531
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-530 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 896.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718    2 AKKVAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFADTSEDGMTRVYRSLVTNVCKEMSCYSDFPFREDYPNF 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   82 MSHEKFWDYLREFAEHFGLLRYIRFKTTVLSVTKRPDFSETGQWDVVTETEGKRDRAVFDAVMVCTGQFLSPHLPLESFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  162 GIHKFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTGTWVLSRSSPGGYPFNMI-QTRWLN 240
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLfSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  241 FLVRVLPSRFINWTHERKMNKILNHENYGLSIAKGKKPK-FIVNDELPTCILCGKVTMKTSVKDFTESSVIFEDGTTEAN 319
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKePVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  320 IDVVIFTTGYEFSFPFFEEPLKSLCTKKIILYKRVFPPNLERATLAIIGLISLNGSILVGTEFQARWATRVFKGLCSIPP 399
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  400 SQKLMAEATK-TEQLIKRGVIKDTSQDKLDFITYMDELTQCIGAKPSIPLLFIKDPRLAWEVFFGPCTPYQYRLVGPGRW 478
Cdd:pfam00743 401 QSEMMAEINKrQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568910718  479 DGARNAILTQWDRTLKPLKTRIVPKSPEPTSlSHYLIAWGAPVLLVSLLLIY 530
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPAS-SFTLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-394 2.24e-87

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 276.36  E-value: 2.24e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   5 VAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFadtsedgmtRVYRSLVTNVCKEMSCYSDFPFREDYPNFMSH 84
Cdd:COG2072    9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRD---------NRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  85 EKFWDYLREFAEHFGLLRYIRFKTTVLSVTKRpdfSETGQWDVVTETeGKRDRAvfDAVMVCTGQFLSPHLPleSFPGIH 164
Cdd:COG2072   80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWD---EADGRWTVTTDD-GETLTA--RFVVVATGPLSRPKIP--DIPGLE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 165 KFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTGTWVLSRsspggYPFNMIQTRWLNFLVR 244
Cdd:COG2072  152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR-----PNYDPERGRPANYLGL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 245 VLPSRFINWTHERKMNKILNHENYGLSIAKgKKPKF-------IVNDELPTCILCGKVTMKTS-VKDFTESSVIFEDGtT 316
Cdd:COG2072  227 EAPPALNRRDARAWLRRLLRAQVKDPELGL-LTPDYppgckrpLLSTDYYEALRRGNVELVTGgIERITEDGVVFADG-T 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 317 EANIDVVIFTTGYEFSFPFFEEPL------KSlctkKIILYKRVFPPNLERatLAIIGLISLNG--SILVGTEFQARWAT 388
Cdd:COG2072  305 EHEVDVIVWATGFRADLPWLAPLDvrgrdgRS----GPRAYLGVVVPGFPN--LFFLGPNSPSGhsSLTLGAERQARYIA 378


                 ....*.
gi 568910718 389 RVFKGL 394
Cdd:COG2072  379 RLIAHM 384
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 2-404 1.54e-40

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 152.71  E-value: 1.54e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   2 AKKVAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFADTSEDG-----------MTRVYRSLVTNVCKEMSCYS 70
Cdd:PLN02172  10 SQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  71 DFPF-------REDYPNFMSHEKFWDYLREFAEHFGLLRYIRFKTTVLSVTkrpdfSETGQWDVVTETEGK-RDRAVFDA 142
Cdd:PLN02172  90 DFPFvprfddeSRDSRRYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGGfSKDEIFDA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 143 VMVCTGQFLSPHLPleSFPGIHKFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTgtwvls 222
Cdd:PLN02172 165 VVVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASRA------ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 223 rSSPGGY-----PFNMIqtrWLNflvrvlpsRFINWTHErkmnkilnhenyglsiakgkkpkfivndelptcilcgkvtm 297
Cdd:PLN02172 237 -SESDTYeklpvPQNNL---WMH--------SEIDTAHE----------------------------------------- 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 298 ktsvkdftESSVIFEDGTTeANIDVVIFTTGYEFSFPFFEEPLKSLCTKKII--LYKRVFPPNLErATLAIIGLISLnGS 375
Cdd:PLN02172 264 --------DGSIVFKNGKV-VYADTIVHCTGYKYHFPFLETNGYMRIDENRVepLYKHVFPPALA-PGLSFIGLPAM-GI 332

                        410       420
                 ....*....|....*....|....*....
gi 568910718 376 ILVGTEFQARWATRVFKGLCSIPPSQKLM 404
Cdd:PLN02172 333 QFVMFEIQSKWVAAVLSGRVTLPSEDKMM 361
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-530 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 896.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718    2 AKKVAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFADTSEDGMTRVYRSLVTNVCKEMSCYSDFPFREDYPNF 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   82 MSHEKFWDYLREFAEHFGLLRYIRFKTTVLSVTKRPDFSETGQWDVVTETEGKRDRAVFDAVMVCTGQFLSPHLPLESFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  162 GIHKFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTGTWVLSRSSPGGYPFNMI-QTRWLN 240
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLfSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  241 FLVRVLPSRFINWTHERKMNKILNHENYGLSIAKGKKPK-FIVNDELPTCILCGKVTMKTSVKDFTESSVIFEDGTTEAN 319
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKePVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  320 IDVVIFTTGYEFSFPFFEEPLKSLCTKKIILYKRVFPPNLERATLAIIGLISLNGSILVGTEFQARWATRVFKGLCSIPP 399
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  400 SQKLMAEATK-TEQLIKRGVIKDTSQDKLDFITYMDELTQCIGAKPSIPLLFIKDPRLAWEVFFGPCTPYQYRLVGPGRW 478
Cdd:pfam00743 401 QSEMMAEINKrQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568910718  479 DGARNAILTQWDRTLKPLKTRIVPKSPEPTSlSHYLIAWGAPVLLVSLLLIY 530
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPAS-SFTLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-394 2.24e-87

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 276.36  E-value: 2.24e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   5 VAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFadtsedgmtRVYRSLVTNVCKEMSCYSDFPFREDYPNFMSH 84
Cdd:COG2072    9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRD---------NRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  85 EKFWDYLREFAEHFGLLRYIRFKTTVLSVTKRpdfSETGQWDVVTETeGKRDRAvfDAVMVCTGQFLSPHLPleSFPGIH 164
Cdd:COG2072   80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWD---EADGRWTVTTDD-GETLTA--RFVVVATGPLSRPKIP--DIPGLE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 165 KFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTGTWVLSRsspggYPFNMIQTRWLNFLVR 244
Cdd:COG2072  152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR-----PNYDPERGRPANYLGL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 245 VLPSRFINWTHERKMNKILNHENYGLSIAKgKKPKF-------IVNDELPTCILCGKVTMKTS-VKDFTESSVIFEDGtT 316
Cdd:COG2072  227 EAPPALNRRDARAWLRRLLRAQVKDPELGL-LTPDYppgckrpLLSTDYYEALRRGNVELVTGgIERITEDGVVFADG-T 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 317 EANIDVVIFTTGYEFSFPFFEEPL------KSlctkKIILYKRVFPPNLERatLAIIGLISLNG--SILVGTEFQARWAT 388
Cdd:COG2072  305 EHEVDVIVWATGFRADLPWLAPLDvrgrdgRS----GPRAYLGVVVPGFPN--LFFLGPNSPSGhsSLTLGAERQARYIA 378


                 ....*.
gi 568910718 389 RVFKGL 394
Cdd:COG2072  379 RLIAHM 384
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 2-404 1.54e-40

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 152.71  E-value: 1.54e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   2 AKKVAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFADTSEDG-----------MTRVYRSLVTNVCKEMSCYS 70
Cdd:PLN02172  10 SQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  71 DFPF-------REDYPNFMSHEKFWDYLREFAEHFGLLRYIRFKTTVLSVTkrpdfSETGQWDVVTETEGK-RDRAVFDA 142
Cdd:PLN02172  90 DFPFvprfddeSRDSRRYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGGfSKDEIFDA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 143 VMVCTGQFLSPHLPleSFPGIHKFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTgtwvls 222
Cdd:PLN02172 165 VVVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASRA------ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 223 rSSPGGY-----PFNMIqtrWLNflvrvlpsRFINWTHErkmnkilnhenyglsiakgkkpkfivndelptcilcgkvtm 297
Cdd:PLN02172 237 -SESDTYeklpvPQNNL---WMH--------SEIDTAHE----------------------------------------- 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 298 ktsvkdftESSVIFEDGTTeANIDVVIFTTGYEFSFPFFEEPLKSLCTKKII--LYKRVFPPNLErATLAIIGLISLnGS 375
Cdd:PLN02172 264 --------DGSIVFKNGKV-VYADTIVHCTGYKYHFPFLETNGYMRIDENRVepLYKHVFPPALA-PGLSFIGLPAM-GI 332

                        410       420
                 ....*....|....*....|....*....
gi 568910718 376 ILVGTEFQARWATRVFKGLCSIPPSQKLM 404
Cdd:PLN02172 333 QFVMFEIQSKWVAAVLSGRVTLPSEDKMM 361
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
72-351 1.98e-18

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 86.12  E-value: 1.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   72 FPFREDYPnfmSHEKFWDYLREFAEHFGLLryIRFKTTVLSVTKrpdfsETGQWDVVTetegkrDRAVFDA--VMVCTGQ 149
Cdd:pfam13738  65 FTFNREHP---SGNEYAEYLRRVADHFELP--INLFEEVTSVKK-----EDDGFVVTT------SKGTYQAryVIIATGE 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  150 FLSPHLPleSFPGIHKfkgqilHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTGTWVLSRSSPGgy 229
Cdd:pfam13738 129 FDFPNKL--GVPELPK------HYSYVKDFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEWEDRDSDPS-- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  230 pfnmiqtRWLNflvrvlPsrfinWTHERkmnkilnhenyglsiakgkkpkfivndeLPTCILCGKVTM--KTSVKDFTES 307
Cdd:pfam13738 199 -------YSLS------P-----DTLNR----------------------------LEELVKNGKIKAhfNAEVKEITEV 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 568910718  308 S----VIFEDGTTEANIDVVIFTTGYEFSFPFFEEPLKSLCTKKIILY 351
Cdd:pfam13738 233 DvsykVHTEDGRKVTSNDDPILATGYHPDLSFLKKGLFELDEDGRPVL 280
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
4-215 1.76e-10

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 62.06  E-value: 1.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   4 KVAVIGAGVSGLS-SIKCCLdENLEPTCFERtSDFGG-LWKfadtsedgMTRVyrslvtnvckemscysdfpfrEDYPNF 81
Cdd:COG0492    2 DVVIIGAGPAGLTaAIYAAR-AGLKTLVIEG-GEPGGqLAT--------TKEI---------------------ENYPGF 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  82 ---MSHEKFWDYLREFAEHFGLlRYIRfkTTVLSVTKrpdfsETGQWDVVTEtEGKRDRAvfDAVMVCTGqfLSP-HLPL 157
Cdd:COG0492   51 pegISGPELAERLREQAERFGA-EILL--EEVTSVDK-----DDGPFRVTTD-DGTEYEA--KAVIIATG--AGPrKLGL 117

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568910718 158 esfPGIHKFKGQILHsqeYRIP-DA--FRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTR 215
Cdd:COG0492  118 ---PGEEEFEGRGVS---YCATcDGffFRGKDVVVVGGGDSALEEALYLTKFASKVTLIHR 172
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 8-215 4.30e-08

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 55.28  E-value: 4.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718    8 IGAGVSGLSsIKCCLDENLEPTC--FERTSDFGglWkfadtsEDGM----TRVYRS----LVT-----------NVCKEM 66
Cdd:pfam13434   8 IGIGPFNLS-LAALLEEIPELDAlfFERQPEFA--W------HPGMllpgATMQTSflkdLVTlrdptspfsflNYLHEH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   67 SCYSDFPFREDYpnFMSHEKFWDYLREFAEHFGllRYIRFKTTVLSVTKRPDfSETGQWDVVTET-EGKRDRAVFDAVMV 145
Cdd:pfam13434  79 GRLYSFYNLETF--FPSRREFNDYLQWAASHLP--NRLRFGQEVESVEPDAE-RGEPLLRVRVRDaDGEETTFLARNLVL 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568910718  146 CTGqfLSPHLPlESFPGihkfKGQILHSQEY--RIPDAFRGKRILVVGLGNTGGDIAVEL--SEIAAQVFLSTR 215
Cdd:pfam13434 154 GTG--GEPYIP-ECARG----GERVFHSSEYleRIDRLAAKKRIAVVGSGQSAAEIFRDLlrRGPAYELTWVTR 220
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 3-251 1.19e-06

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 50.76  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   3 KKVAVIGAGVSGLSS---IKCcldENLEPTCFERTSDFGGLWKFA--------DTSEDGMTRVYRSLVTNVCKEMSCYSD 71
Cdd:PRK12770  19 KKVAIIGAGPAGLAAagyLAC---LGYEVHVYDKLPEPGGLMLFGipefripiERVREGVKELEEAGVVFHTRTKVCCGE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  72 FPFREDYPnfmshekfwdylrEFAEHFgllryIRFKttvlsvtkrpdfsetgqwDVVTEtegkrdravFDAVMVCTGQFL 151
Cdd:PRK12770  96 PLHEEEGD-------------EFVERI-----VSLE------------------ELVKK---------YDAVLIATGTWK 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 152 S--PHLPLESFPGI-------HKFKG-QILHSQEYRIPDaFRGKRILVVGLGNTGGDIAVE-LSEIAAQVFLSTRTGtwv 220
Cdd:PRK12770 131 SrkLGIPGEDLPGVysaleylFRIRAaKLGYLPWEKVPP-VEGKKVVVVGAGLTAVDAALEaVLLGAEKVYLAYRRT--- 206

                        250       260       270
                 ....*....|....*....|....*....|..
gi 568910718 221 lSRSSPGG-YPFNMIQTRWLNFLVRVLPSRFI 251
Cdd:PRK12770 207 -INEAPAGkYEIERLIARGVEFLELVTPVRII 237
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
2-242 8.32e-06

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 48.41  E-value: 8.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   2 AKKVAVIGAGVSGLS---SIKCCLDENLEPTCFERTSDFG-GLwKFADTSEdgmtrvyrSLVTNVC-KEMSCYSDFPfrE 76
Cdd:COG4529    5 RKRIAIIGGGASGTAlaiHLLRRAPEPLRITLFEPRPELGrGV-AYSTDSP--------EHLLNVPaGRMSAFPDDP--D 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  77 DYPNFMSHEKFW-----------------DYLREF-------AEHFGLLRYIRFKttVLSVTKrpdfsETGQWDVVTETE 132
Cdd:COG4529   74 HFLRWLRENGARaapaidpdafvprrlfgEYLRERlaealarAPAGVRLRHIRAE--VVDLER-----DDGGYRVTLADG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718 133 gkrDRAVFDAVMVCTGqflspHLPLESFPGIHKFKGQILHS--QEYRIPDAFRGKRILVVGLGNTGGDIAVELSEI--AA 208
Cdd:COG4529  147 ---ETLRADAVVLATG-----HPPPAPPPGLAAGSPRYIADpwPPGALARIPPDARVLIIGTGLTAIDVVLSLAARghRG 218

                        250       260       270
                 ....*....|....*....|....*....|....
gi 568910718 209 QVFLSTRTGTWVLSRSSPGGYPFNMIQTRWLNFL 242
Cdd:COG4529  219 PITALSRRGLLPRAHPPGAPLPLKFLTPEALEEL 252
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 3-209 3.07e-05

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 46.16  E-value: 3.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718    3 KKVAVIGAGVSGLSSIKCCLDENLEPTCFErtsdfgglwkfadtseDGMTRVYRSLVtnVCKEMSCYSDFPfredypNFM 82
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIE----------------DEGTCPYGGCV--LSKALLGAAEAP------EIA 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   83 SHekFWDYLREFAEHFGLLRY---IRFKTTVLSVTKrpdfsETGQWDVVTETEGKRDRAVFDAVMVCTGQflSPHLPleS 159
Cdd:pfam07992  57 SL--WADLYKRKEEVVKKLNNgieVLLGTEVVSIDP-----GAKKVVLEELVDGDGETITYDRLVIATGA--RPRLP--P 125

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568910718  160 FPGIHK--FKGQILHSQEYRIPDAFRGKRILVVGlgntGGDIAVELSEIAAQ 209
Cdd:pfam07992 126 IPGVELnvGFLVRTLDSAEALRLKLLPKRVVVVG----GGYIGVELAAALAK 173
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 3-200 3.92e-03

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 39.73  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718   3 KKVAVIGAGVSGLSsikcCLDEnL-----EPTCFERTSDFGGLwkfadtsedgMTrvyrslvtnvckemscysdfpfred 77
Cdd:COG0493  122 KKVAVVGSGPAGLA----AAYQ-LaraghEVTVFEALDKPGGL----------LR------------------------- 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910718  78 Y--PNFMSHEKFWDYLREFAEHFGllryIRFKT-TVLSVTkrpdfsetgqwdvVTETEGKRDravFDAVMVCTGQFLSPH 154
Cdd:COG0493  162 YgiPEFRLPKDVLDREIELIEALG----VEFRTnVEVGKD-------------ITLDELLEE---FDAVFLATGAGKPRD 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568910718 155 LPL--ESFPGIHK---F-KGQILHSQEYRIPDAfrGKRILVVGLGNTGGDIA 200
Cdd:COG0493  222 LGIpgEDLKGVHSamdFlTAVNLGEAPDTILAV--GKRVVVIGGGNTAMDCA 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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