Mlxip MLX interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mlxipprovided by MGI
Official Full Name: MLX interacting proteinprovided by MGI
Primary source: MGI:MGI:2141183
See related: Ensembl:ENSMUSG00000038342 AllianceGenome:MGI:2141183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mir; bHLHe36
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within nucleocytoplasmic transport. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; craniocervical region bone; rib; testis; and urinary system. Orthologous to human MLXIP (MLX interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 18.7), colon adult (RPKM 18.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.95 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (123532438..123595998)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (123394521..123457932)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment.
Title: MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment.
MondoA drives muscle lipid accumulation and insulin resistance.
Title: MondoA drives muscle lipid accumulation and insulin resistance.
Data (including data from studies in knockout mice) suggest that MondoA shuttles to nucleus of pancreatic beta-cells where it is required for induction of glucose-responsive genes arrestin domain-containing protein 4 (Arrdc4) and thioredoxin interacting protein (Txnip).
Title: MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells.
MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin signaling
Title: MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.
Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism.
Title: Contrasting Patterns in the Evolution of Vertebrate MLX Interacting Protein (MLXIP) and MLX Interacting Protein-Like (MLXIPL) Genes.
MondoA is a basic helix-loop-helix/leucine zipper transcription factor that is expressed predominantly in skeletal muscle. Mice deficient for MondoA excel in sprinting, as their skeletal muscles display an enhanced glycolytic capacity.
Title: MondoA deficiency enhances sprint performance in mice.
MondoA-Mlx complexes sense elevated levels of G6P and adenine nucleotides to trigger a TXNIP-dependent feedback inhibition of glycolysis
Title: MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein.
Suppression of Txnip by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei.
Title: Thioredoxin-interacting protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responses.
the MondoA-TXNIP regulatory circuit has a role in the hexose transport curb, although other redundant pathways also contribute
Title: MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb.
Induction of TXNIP under lactic acidosis is caused by the activation of the glucose-sensing helix-loop-helix transcriptional complex MondoA:Mlx, which is usually triggered upon glucose exposure.
Title: Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit65 (e-PCR), detects polymorphism
- UniSTS:130604

NoName (e-PCR)
- UniSTS:235311

NoName (e-PCR)
- UniSTS:235313

NoName (e-PCR)
- UniSTS:235314

AW228700 (e-PCR)
- UniSTS:179263

NoName (e-PCR)
- UniSTS:224342

D5Mit413 (e-PCR), detects polymorphism
- UniSTS:142553

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within nucleocytoplasmic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MLX-interacting protein

Names: Mlx interactor; transcriptional activator MondoA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133917.3 → NP_598678.2 MLX-interacting protein isoform 2

See identical proteins and their annotated locations for NP_598678.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).

Source sequence(s)

AK047475, AY968204, BC067045

Consensus CDS

CCDS19662.1

UniProtKB/Swiss-Prot

Q2VPU4, Q6NXJ4, Q6P9J8, Q8C8C6, Q8VI53

UniProtKB/TrEMBL

G5E8D8

Related

ENSMUSP00000064943.6, ENSMUST00000068237.12

Conserved Domains (3) summary

cd00083
Location:717 → 771

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam01698
Location:425 → 476

FLO_LFY; Floricaula / Leafy protein

cl21462
Location:758 → 799

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_177582.3 → NP_808250.1 MLX-interacting protein isoform 1

See identical proteins and their annotated locations for NP_808250.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 1 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK047475, BB349293

Consensus CDS

CCDS39268.1

UniProtKB/TrEMBL

B2RQ56

Related

ENSMUSP00000107223.2, ENSMUST00000111596.8

Conserved Domains (1) summary

pfam01698
Location:425 → 476

FLO_LFY; Floricaula / Leafy protein