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kmo-2 FAD-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187655, updated on 4-Jan-2025

Summary

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Official Symbol
kmo-2
Official Full Name
FAD-binding domain-containing protein
Primary source
WormBase:WBGene00011088
Locus tag
CELE_R07B7.4
See related
AllianceGenome:WB:WBGene00011088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable kynurenine 3-monooxygenase activity. Predicted to be involved in kynurenine metabolic process. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See kmo-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (12065965..12067957, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Chloride channel protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene Kynurenine 3-monooxygenase Neighboring gene Nucleotid_trans domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine 3-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in kynurenine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FAD-binding domain-containing protein
NP_001129902.1
  • Confirmed by transcript evidence
NP_001359579.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12065965..12067957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373128.2 → NP_001359579.1  FAD-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21794
    Conserved Domains (1) summary
    COG0654
    Location:9 → 304
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

  2. NM_001136430.1 → NP_001129902.1  FAD-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129902.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5BM30
    Conserved Domains (1) summary
    COG0654
    Location:1 → 344
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
Nucleotide Protein
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