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Conserved domains on  [gi|212646493|ref|NP_001129902|]
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FAD-binding domain-containing protein [Caenorhabditis elegans]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11428987)

FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0071949|GO:0016491

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-344 5.42e-35

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 132.37  E-value: 5.42e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   1 MPSVVIAGGGLVGSANACFFGQKGWIVDVYESR----FDPRGnhmengksinLALGVRAMSTMKRIGLKEKVIHIGVPIR 76
Cdd:COG0654    3 RTDVLIVGGGPAGLALALALARAGIRVTVVERAppprPDGRG----------IALSPRSLELLRRLGLWDRLLARGAPIR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  77 DQIAHFGDTKGKLKRLPVLNDD-DFILTINRQELSQILINEAEKYnNVKFHFNCKATKFDLKSESLIVQNSDNlSTVDGD 155
Cdd:COG0654   73 GIRVRDGSDGRVLARFDAAETGlPAGLVVPRADLERALLEAARAL-GVELRFGTEVTGLEQDADGVTVTLADG-RTLRAD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 156 LFLACDGAHSSIRRSL-LKAPGFNFSQKyseFGYIDLSVNstqqcdlklgthysWRRRgiilvaivnkdqsltvsmFATF 234
Cdd:COG0654  151 LVVGADGARSAVRRLLgIGFTGRDYPQR---ALWAGVRTE--------------LRAR------------------LAAA 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 235 sefesnlvgpvesvlffknnFYEIFKILgedhirnTIARNKPQAIISVQCSQHVfFDKLVLMGDAAHAMVPFNGQGVNCG 314
Cdd:COG0654  196 --------------------GPRLGELL-------ELSPRSAFPLRRRRAERWR-RGRVVLLGDAAHTMHPLGGQGANLA 247

                        330       340       350
                 ....*....|....*....|....*....|.
gi 212646493 315 FEDCLVLQEIMDQYEEDE-LEDVIKEYSKVR 344
Cdd:COG0654  248 LRDAAALAWKLAAALRGRdDEAALARYERER 278
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-344 5.42e-35

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 132.37  E-value: 5.42e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   1 MPSVVIAGGGLVGSANACFFGQKGWIVDVYESR----FDPRGnhmengksinLALGVRAMSTMKRIGLKEKVIHIGVPIR 76
Cdd:COG0654    3 RTDVLIVGGGPAGLALALALARAGIRVTVVERAppprPDGRG----------IALSPRSLELLRRLGLWDRLLARGAPIR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  77 DQIAHFGDTKGKLKRLPVLNDD-DFILTINRQELSQILINEAEKYnNVKFHFNCKATKFDLKSESLIVQNSDNlSTVDGD 155
Cdd:COG0654   73 GIRVRDGSDGRVLARFDAAETGlPAGLVVPRADLERALLEAARAL-GVELRFGTEVTGLEQDADGVTVTLADG-RTLRAD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 156 LFLACDGAHSSIRRSL-LKAPGFNFSQKyseFGYIDLSVNstqqcdlklgthysWRRRgiilvaivnkdqsltvsmFATF 234
Cdd:COG0654  151 LVVGADGARSAVRRLLgIGFTGRDYPQR---ALWAGVRTE--------------LRAR------------------LAAA 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 235 sefesnlvgpvesvlffknnFYEIFKILgedhirnTIARNKPQAIISVQCSQHVfFDKLVLMGDAAHAMVPFNGQGVNCG 314
Cdd:COG0654  196 --------------------GPRLGELL-------ELSPRSAFPLRRRRAERWR-RGRVVLLGDAAHTMHPLGGQGANLA 247

                        330       340       350
                 ....*....|....*....|....*....|.
gi 212646493 315 FEDCLVLQEIMDQYEEDE-LEDVIKEYSKVR 344
Cdd:COG0654  248 LRDAAALAWKLAAALRGRdDEAALARYERER 278
PRK06753 PRK06753
hypothetical protein; Provisional
 4-353 1.85e-16

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 80.50  E-value: 1.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   4 VVIAGGGLVGSANACFFGQKGWIVDVYESrfdprgNHMENGKSINLALGVRAMSTMKRIGLKEKVIHIGvpirDQIAHFG 83
Cdd:PRK06753   3 IAIIGAGIGGLTAAALLQEQGHEVKVFEK------NESVKEVGAGIGIGDNVIKKLGNHDLAKGIKNAG----QILSTMN 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  84 --DTKG------KLKRLPVLndddfiLTINRQELSQILINEaekYNNVKFHFNCKATKFDLKSESLIVQNSDNlSTVDGD 155
Cdd:PRK06753  73 llDDKGtllnkvKLKSNTLN------VTLHRQTLIDIIKSY---VKEDAIFTGKEVTKIENETDKVTIHFADG-ESEAFD 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 156 LFLACDGAHSSIRRSLLKAPGFNFsQKYSEF-GYIDlsvnstqQCDLKLGTHYS--WRRRGII-LVAIVNKDQSLTVSMF 231
Cdd:PRK06753 143 LCIGADGIHSKVRQSVNADSKVRY-QGYTCFrGLID-------DIDLKLPDCAKeyWGTKGRFgIVPLLNNQAYWFITIN 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 232 ATFSEFESNLVGPVESVLFFKNNFYEIFKILGEDHIRNTIARNkpqaIISVQCSQHVFFDKLVLMGDAAHAMVPFNGQGV 311
Cdd:PRK06753 215 AKERDPKYSSFGKPHLQAYFNHYPNEVREILDKQSETGILHHD----IYDLKPLKSFVYGRIVLLGDAAHATTPNMGQGA 290

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 212646493 312 NCGFEDCLVLQEIMDQYeedELEDVIKEYSKVRTNET-NIINQ 353
Cdd:PRK06753 291 GQAMEDAIVLANCLNAY---DFEKALQRYDKIRVKHTaKVIKR 330
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 4-331 1.56e-11

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 65.42  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493    4 VVIAGGGLVGSANACFFGQKG---WIVDVYESRF-DPRGnhmengksinLALGVRAMSTMKRIGLKEKVIHIGVPIrdqi 79
Cdd:pfam01494   4 VLIVGGGPAGLMLALLLARAGvrvVLVERHATTSvLPRA----------HGLNQRTMELLRQAGLEDRILAEGVPH---- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   80 AHFGDTKGKLKRLPVLNDDD---FILTINRQELSQILINEAEKYNnVKFHFNCKATKF--DLKSESLIVQNSDN--LSTV 152
Cdd:pfam01494  70 EGMGLAFYNTRRRADLDFLTsppRVTVYPQTELEPILVEHAEARG-AQVRFGTEVLSLeqDGDGVTAVVRDRRDgeEYTV 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  153 DGDLFLACDGAHSSIRRSL-LKAPGFnfsqKYSEFGYIDLSVNSTqqcDLKLgthysWRRRGIILVAIvnkdqsltvsmf 231
Cdd:pfam01494 149 RAKYLVGCDGGRSPVRKTLgIEFEGF----EGVPFGSLDVLFDAP---DLSD-----PVERAFVHYLI------------ 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  232 aTFSEFESNLVGPVESVlfFKNNFYeIFKILGEDHIRNTIARNKPQAI-----------------------ISVQCSQHV 288
Cdd:pfam01494 205 -YAPHSRGFMVGPWRSA--GRERYY-VQVPWDEEVEERPEEFTDEELKqrlrsivgidlalveilwksiwgVASRVATRY 280

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 212646493  289 FFDKLVLMGDAAHAMVPFNGQGVNCGFED--------CLVL-----QEIMDQYEED 331
Cdd:pfam01494 281 RKGRVFLAGDAAHIHPPTGGQGLNTAIQDafnlawklAAVLrgqagESLLDTYSAE 336
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 4-344 7.52e-10

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 60.29  E-value: 7.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493    4 VVIAGGGLVGSANACFFGQKGWIV---------DVYESRFDPRgnhmengksiNLALGVRAMSTMKRIGLKEKVIHIGV- 73
Cdd:TIGR01988   2 IVIVGGGMVGLALALALARSGLKValieatplpAPADPGFDNR----------VSALSAASIRLLEKLGVWDKIEPARAq 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   74 PIRDqiAHF--GDTKGKLK-RLPVLNDDDFILTINRQELSQILINEAEKYNNVKFHFN--CKATKFDLKSESLIVQNSDN 148
Cdd:TIGR01988  72 PIRD--IHVsdGGSFGALRfDADEIGLEALGYVVENRVLQQALWERLQELPNVTLLCParVVELPRHSDHVELTLDDGQQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  149 LSTvdgDLFLACDGAHSSIRRSL-LKAPGFNFSQkysefgyidLSVNSTQQCDLKLGtHYSWRR---RGII--------- 215
Cdd:TIGR01988 150 LRA---RLLVGADGANSKVRQLAgIPTTGWDYGQ---------SAVVANVKHERPHQ-GTAWERftpTGPLallplpdnr 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  216 --LVAIVNKDQSLTV-SMfatfsefesnlvgPVESVLFFKNN----FYEIFKILGEDHI---RNTIArnkpqaiisvqcs 285
Cdd:TIGR01988 217 ssLVWTLPPEEAERLlAL-------------SDEEFLAELQRafgsRLGAITLVGERHAfplSLTHA------------- 270

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212646493  286 qHVFFDK-LVLMGDAAHAMVPFNGQGVNCGFEDCLVLQEIMDQYEEDeLED-----VIKEYSKVR 344
Cdd:TIGR01988 271 -KRYVAPrLALIGDAAHTIHPLAGQGLNLGLRDVAALAEVLEDARRR-GEDigslrVLQRYERRR 333
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-344 5.42e-35

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 132.37  E-value: 5.42e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   1 MPSVVIAGGGLVGSANACFFGQKGWIVDVYESR----FDPRGnhmengksinLALGVRAMSTMKRIGLKEKVIHIGVPIR 76
Cdd:COG0654    3 RTDVLIVGGGPAGLALALALARAGIRVTVVERAppprPDGRG----------IALSPRSLELLRRLGLWDRLLARGAPIR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  77 DQIAHFGDTKGKLKRLPVLNDD-DFILTINRQELSQILINEAEKYnNVKFHFNCKATKFDLKSESLIVQNSDNlSTVDGD 155
Cdd:COG0654   73 GIRVRDGSDGRVLARFDAAETGlPAGLVVPRADLERALLEAARAL-GVELRFGTEVTGLEQDADGVTVTLADG-RTLRAD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 156 LFLACDGAHSSIRRSL-LKAPGFNFSQKyseFGYIDLSVNstqqcdlklgthysWRRRgiilvaivnkdqsltvsmFATF 234
Cdd:COG0654  151 LVVGADGARSAVRRLLgIGFTGRDYPQR---ALWAGVRTE--------------LRAR------------------LAAA 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 235 sefesnlvgpvesvlffknnFYEIFKILgedhirnTIARNKPQAIISVQCSQHVfFDKLVLMGDAAHAMVPFNGQGVNCG 314
Cdd:COG0654  196 --------------------GPRLGELL-------ELSPRSAFPLRRRRAERWR-RGRVVLLGDAAHTMHPLGGQGANLA 247

                        330       340       350
                 ....*....|....*....|....*....|.
gi 212646493 315 FEDCLVLQEIMDQYEEDE-LEDVIKEYSKVR 344
Cdd:COG0654  248 LRDAAALAWKLAAALRGRdDEAALARYERER 278
PRK06753 PRK06753
hypothetical protein; Provisional
 4-353 1.85e-16

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 80.50  E-value: 1.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   4 VVIAGGGLVGSANACFFGQKGWIVDVYESrfdprgNHMENGKSINLALGVRAMSTMKRIGLKEKVIHIGvpirDQIAHFG 83
Cdd:PRK06753   3 IAIIGAGIGGLTAAALLQEQGHEVKVFEK------NESVKEVGAGIGIGDNVIKKLGNHDLAKGIKNAG----QILSTMN 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  84 --DTKG------KLKRLPVLndddfiLTINRQELSQILINEaekYNNVKFHFNCKATKFDLKSESLIVQNSDNlSTVDGD 155
Cdd:PRK06753  73 llDDKGtllnkvKLKSNTLN------VTLHRQTLIDIIKSY---VKEDAIFTGKEVTKIENETDKVTIHFADG-ESEAFD 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 156 LFLACDGAHSSIRRSLLKAPGFNFsQKYSEF-GYIDlsvnstqQCDLKLGTHYS--WRRRGII-LVAIVNKDQSLTVSMF 231
Cdd:PRK06753 143 LCIGADGIHSKVRQSVNADSKVRY-QGYTCFrGLID-------DIDLKLPDCAKeyWGTKGRFgIVPLLNNQAYWFITIN 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 232 ATFSEFESNLVGPVESVLFFKNNFYEIFKILGEDHIRNTIARNkpqaIISVQCSQHVFFDKLVLMGDAAHAMVPFNGQGV 311
Cdd:PRK06753 215 AKERDPKYSSFGKPHLQAYFNHYPNEVREILDKQSETGILHHD----IYDLKPLKSFVYGRIVLLGDAAHATTPNMGQGA 290

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 212646493 312 NCGFEDCLVLQEIMDQYeedELEDVIKEYSKVRTNET-NIINQ 353
Cdd:PRK06753 291 GQAMEDAIVLANCLNAY---DFEKALQRYDKIRVKHTaKVIKR 330
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 4-331 1.56e-11

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 65.42  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493    4 VVIAGGGLVGSANACFFGQKG---WIVDVYESRF-DPRGnhmengksinLALGVRAMSTMKRIGLKEKVIHIGVPIrdqi 79
Cdd:pfam01494   4 VLIVGGGPAGLMLALLLARAGvrvVLVERHATTSvLPRA----------HGLNQRTMELLRQAGLEDRILAEGVPH---- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   80 AHFGDTKGKLKRLPVLNDDD---FILTINRQELSQILINEAEKYNnVKFHFNCKATKF--DLKSESLIVQNSDN--LSTV 152
Cdd:pfam01494  70 EGMGLAFYNTRRRADLDFLTsppRVTVYPQTELEPILVEHAEARG-AQVRFGTEVLSLeqDGDGVTAVVRDRRDgeEYTV 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  153 DGDLFLACDGAHSSIRRSL-LKAPGFnfsqKYSEFGYIDLSVNSTqqcDLKLgthysWRRRGIILVAIvnkdqsltvsmf 231
Cdd:pfam01494 149 RAKYLVGCDGGRSPVRKTLgIEFEGF----EGVPFGSLDVLFDAP---DLSD-----PVERAFVHYLI------------ 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  232 aTFSEFESNLVGPVESVlfFKNNFYeIFKILGEDHIRNTIARNKPQAI-----------------------ISVQCSQHV 288
Cdd:pfam01494 205 -YAPHSRGFMVGPWRSA--GRERYY-VQVPWDEEVEERPEEFTDEELKqrlrsivgidlalveilwksiwgVASRVATRY 280

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 212646493  289 FFDKLVLMGDAAHAMVPFNGQGVNCGFED--------CLVL-----QEIMDQYEED 331
Cdd:pfam01494 281 RKGRVFLAGDAAHIHPPTGGQGLNTAIQDafnlawklAAVLrgqagESLLDTYSAE 336
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
9-312 9.11e-11

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 62.29  E-value: 9.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   9 GGLVGSANACFFGQKGWIVDVYESRFDPRGNHM-EngksinlALGVRAMSTMKRIGLKEKVIHigvPIRDQIAHFGDtkG 87
Cdd:COG0644    1 AGPAGSAAARRLARAGLSVLLLEKGSFPGDKICgG-------GLLPRALEELEPLGLDEPLER---PVRGARFYSPG--G 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  88 KLKRLPVlnDDDFILTINRQELSQILINEAEKYNnVKFHFNCKATKFDLKSESLIVQnSDNLSTVDGDLFLACDGAHSSI 167
Cdd:COG0644   69 KSVELPP--GRGGGYVVDRARFDRWLAEQAEEAG-AEVRTGTRVTDVLRDDGRVVVR-TGDGEEIRADYVVDADGARSLL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 168 RRSLlkapgfnfsqkysefgyidlsvnstqqcdlklgthyswrrrgiILVAIVNKDQSLTVSMFATFSEFESNLVGPVES 247
Cdd:COG0644  145 ARKL-------------------------------------------GLKRRSDEPQDYALAIKEHWELPPLEGVDPGAV 181

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212646493 248 VLFFKNNFYE----IFKiLGEDHIRNTIARNKPQaiisvqcsQHVFFDKLVLMGDAAHAMVPFNGQGVN 312
Cdd:COG0644  182 EFFFGEGAPGgygwVFP-LGDGRVSVGIPLGGPR--------PRLVGDGVLLVGDAAGFVDPLTGEGIH 241
PRK06475 PRK06475
FAD-binding protein;
3-345 4.19e-10

FAD-binding protein;


Pssm-ID: 180582 [Multi-domain]  Cd Length: 400  Bit Score: 61.38  E-value: 4.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   3 SVVIAGGGLVGSANACFFGQKGWIVDVYESRfdprgNHMEN-GKSINLAlgVRAMSTMKRIGLKEKVIHIGVpirdqIAH 81
Cdd:PRK06475   4 SPLIAGAGVAGLSAALELAARGWAVTIIEKA-----QELSEvGAGLQLA--PNAMRHLERLGVADRLSGTGV-----TPK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  82 FGDTKGKLKRLPVLNDDDFIL----------TINRQELSQILINEAEKYNNVKFHFNCKATKFDLKSESLIVQ--NSDNL 149
Cdd:PRK06475  72 ALYLMDGRKARPLLAMQLGDLarkrwhhpyiVCHRADLQSALLDACRNNPGIEIKLGAEMTSQRQTGNSITATiiRTNSV 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 150 STVDGDLFLACDGAHSSIRRsllKAP--GFNFS-----QKYSEFGYIDLSVNSTQQcDLKLGTHYSWRRRGIILVAIvnk 222
Cdd:PRK06475 152 ETVSAAYLIACDGVWSMLRA---KAGfsKARFSghiawRTTLAADALPASFLSAMP-EHKAVSAWLGNKAHFIAYPV--- 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 223 dQSLTVSMFATFSEFESNLVG------PVESVLFFKNNFYEIFKILgeDHIRNTiarnKPQAIISVQCSQHVFFDKLVLM 296
Cdd:PRK06475 225 -KGGKFFNFVAITGGENPGEVwsktgdKAHLKSIYADWNKPVLQIL--AAIDEW----TYWPLFEMADAQFVGPDRTIFL 297

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 212646493 297 GDAAHAMVPFNGQGVNCGFEDCLVLQEIMDQyeeDELEDVIKEYSKVRT 345
Cdd:PRK06475 298 GDASHAVTPFAAQGAAMAIEDAAALAEALDS---DDQSAGLKRFDSVRK 343
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 4-344 7.52e-10

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 60.29  E-value: 7.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493    4 VVIAGGGLVGSANACFFGQKGWIV---------DVYESRFDPRgnhmengksiNLALGVRAMSTMKRIGLKEKVIHIGV- 73
Cdd:TIGR01988   2 IVIVGGGMVGLALALALARSGLKValieatplpAPADPGFDNR----------VSALSAASIRLLEKLGVWDKIEPARAq 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   74 PIRDqiAHF--GDTKGKLK-RLPVLNDDDFILTINRQELSQILINEAEKYNNVKFHFN--CKATKFDLKSESLIVQNSDN 148
Cdd:TIGR01988  72 PIRD--IHVsdGGSFGALRfDADEIGLEALGYVVENRVLQQALWERLQELPNVTLLCParVVELPRHSDHVELTLDDGQQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  149 LSTvdgDLFLACDGAHSSIRRSL-LKAPGFNFSQkysefgyidLSVNSTQQCDLKLGtHYSWRR---RGII--------- 215
Cdd:TIGR01988 150 LRA---RLLVGADGANSKVRQLAgIPTTGWDYGQ---------SAVVANVKHERPHQ-GTAWERftpTGPLallplpdnr 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  216 --LVAIVNKDQSLTV-SMfatfsefesnlvgPVESVLFFKNN----FYEIFKILGEDHI---RNTIArnkpqaiisvqcs 285
Cdd:TIGR01988 217 ssLVWTLPPEEAERLlAL-------------SDEEFLAELQRafgsRLGAITLVGERHAfplSLTHA------------- 270

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212646493  286 qHVFFDK-LVLMGDAAHAMVPFNGQGVNCGFEDCLVLQEIMDQYEEDeLED-----VIKEYSKVR 344
Cdd:TIGR01988 271 -KRYVAPrLALIGDAAHTIHPLAGQGLNLGLRDVAALAEVLEDARRR-GEDigslrVLQRYERRR 333
PRK06126 PRK06126
hypothetical protein; Provisional
 3-317 2.56e-09

hypothetical protein; Provisional


Pssm-ID: 235704 [Multi-domain]  Cd Length: 545  Bit Score: 59.24  E-value: 2.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   3 SVVIAGGGLVGSANACFFGQKGWIVDVYE----SRFDPRGNHmengksinlaLGVRAMSTMKRIGLKEKVIHIGVPiRD- 77
Cdd:PRK06126   9 PVLIVGGGPVGLALALDLGRRGVDSILVErkdgTAFNPKANT----------TSARSMEHFRRLGIADEVRSAGLP-VDy 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  78 --QIAHF-GDTKGKLKRL----------PVLNDDDFILT------INRQELSQILINEAEKYNNVKFHFNCKATKFDLKS 138
Cdd:PRK06126  78 ptDIAYFtRLTGYELARFrlpsareaitPVGGPDGSWPSpelphrIPQKYLEPILLEHAAAQPGVTLRYGHRLTDFEQDA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 139 ESLIVQ----NSDNLSTVDGDLFLACDGAHSSIRRSL-----------------LKAPGFNFSQKYSEfGYIDLSVNStq 197
Cdd:PRK06126 158 DGVTATvedlDGGESLTIRADYLVGCDGARSAVRRSLgisyegtsglqrdlsiyIRAPGLAALVGHDP-AWMYWLFNP-- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 198 qcdlklgthyswRRRGiILVAIVNKDQSLTVSMFATFSEFESNLVGPVESVlffknnfyeiFKILGEDhIRNTIARNKP- 276
Cdd:PRK06126 235 ------------DRRG-VLVAIDGRDEWLFHQLRGGEDEFTIDDVDARAFV----------RRGVGED-IDYEVLSVVPw 290

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 212646493 277 --QAIISVQCSQhvffDKLVLMGDAAHAMVPFNGQGVNCGFED 317
Cdd:PRK06126 291 tgRRLVADSYRR----GRVFLAGDAAHLFTPTGGYGMNTGIGD 329
PRK06617 PRK06617
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 1-376 1.83e-07

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 168629 [Multi-domain]  Cd Length: 374  Bit Score: 53.00  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   1 MPSVVIAGGGLVGSANACFFGQKGWIVDVYESRFDPRGNHMENGKSInlALGVRAMSTMKRIGLKEKVIHIGVPIRDqiA 80
Cdd:PRK06617   1 MSNTVILGCGLSGMLTALSFAQKGIKTTIFESKSVKSPEFFKDIRTT--ALTPHSKNFLFSIDIWEELEKFVAEMQD--I 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  81 HFGDTKGKlKRLPVLNDDDFIL--TINRQELSQILIN-----------EAEKYNNVKFHFNCKATKFDLKSeslivqnsd 147
Cdd:PRK06617  77 YVVDNKAS-EILDLRNDADAVLgyVVKNSDFKKILLSkitnnplitliDNNQYQEVISHNDYSIIKFDDKQ--------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 148 nlstVDGDLFLACDGAHSSIR---------RSLLKAPGFNFSQKYSEfgyidlsVNSTQQCDLKLGThyswrrrgiiLVA 218
Cdd:PRK06617 147 ----IKCNLLIICDGANSKVRshyfaneieKPYQTALTFNIKHEKPH-------ENCAMEHFLPLGP----------FAL 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 219 IVNKDQSLTVSMFATFSEFESNLVG-PVESVLFFKNNfyEIFKILGEDHIRNTIARNKPQAIISvqcsQHVFFDKLVLMG 297
Cdd:PRK06617 206 LPLKDQYASSVIWSTSSDQAALIVNlPVEEVRFLTQR--NAGNSLGKITIDSEISSFPLKARIA----NRYFHNRIVLIA 279

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212646493 298 DAAHAMVPFNGQGVNCGFEDCLVLQEIMDQyeedelEDVIKEYSKVRTNETNIINQMEWDVNlTLTSSVHGSLGWIREI 376
Cdd:PRK06617 280 DTAHTVHPLAGQGLNQGIKDIEILSMIVSN------NGTLQEYQKLRQEDNFIMYKLTDELN-NIFSNYSKNLRCLRQI 351
PRK07045 PRK07045
putative monooxygenase; Reviewed
 4-344 2.15e-07

putative monooxygenase; Reviewed


Pssm-ID: 136171 [Multi-domain]  Cd Length: 388  Bit Score: 52.60  E-value: 2.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   4 VVIAGGGLVGSANACFFGQKGWIVDVYESrfdPRGNHMENGKSINLALGVRAMSTMkriGLKEKVIHIGVPIRDQIAHFG 83
Cdd:PRK07045   8 VLINGSGIAGVALAHLLGARGHSVTVVER---AARNRAQNGADLLKPSGIGVVRAM---GLLDDVFAAGGLRRDAMRLYH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  84 DtKGKLKRLPVLNDDD---FILtINRQELSQILINEAEKYNNVKFHFNCKATKFDLKSESLIvqnsDNLSTVDGD----- 155
Cdd:PRK07045  82 D-KELIASLDYRSASAlgyFIL-IPCEQLRRLLLAKLDGLPNVRLRFETSIERIERDADGTV----TSVTLSDGErvapt 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 156 LFLACDGAHSSIRRSLLKAPGFNFSqkYSE---FGYIDLSvNSTQQC-----DLKLGTHYSW-----RRRgiiLVAIVNK 222
Cdd:PRK07045 156 VLVGADGARSMIRDDVLRMPAERVP--YATpmaFGTIALT-DSVRECnrlyvDSNQGLAYFYpigdqATR---LVVSFPA 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 223 DQSLTV-------SMFATFSEFESNLVGPVESVLFFKNNFYEIfkILGEDHIRNTIARNkpqaiisvqcsqhvffdkLVL 295
Cdd:PRK07045 230 DEMQGYladttrtKLLARLNEFVGDESADAMAAIGAGTAFPLI--PLGRMNLDRYHKRN------------------VVL 289

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 212646493 296 MGDAAHAMVPFNGQGVNCGFEDCLVLQEIMDQYEEDE--LEDVIKEYSKVR 344
Cdd:PRK07045 290 LGDAAHSIHPITGQGMNLAIEDAGELGACLDLHLSGQiaLADALERFERIR 340
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 285-376 2.69e-07

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 52.47  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 285 SQHVFFDKLVLMGDAAHAMVPFNGQGVNCGFEDCLVLQEIMDqyEEDELED-VIKEYSKVRTNEtNIINQMEWDVNLTLT 363
Cdd:PRK08849 273 AQQYVKNNCVLLGDAAHTINPLAGQGVNLGFKDVDVLLAETE--KQGVLNDaSFARYERRRRPD-NLLMQTGMDLFYKTF 349

                         90
                 ....*....|...
gi 212646493 364 SSVHGSLGWIREI 376
Cdd:PRK08849 350 SNSLTPLKFVRNA 362
PRK08163 PRK08163
3-hydroxybenzoate 6-monooxygenase;
2-172 3.50e-07

3-hydroxybenzoate 6-monooxygenase;


Pssm-ID: 181262 [Multi-domain]  Cd Length: 396  Bit Score: 51.96  E-value: 3.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   2 PSVVIAGGGLVGSANACFFGQKGWIVDVYEsrfdpRGNHM-ENGKSINlaLGVRAMSTMKRIGLKEKVIHIGVPIRDQIA 80
Cdd:PRK08163   5 TPVLIVGGGIGGLAAALALARQGIKVKLLE-----QAAEIgEIGAGIQ--LGPNAFSALDALGVGEAARQRAVFTDHLTM 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  81 HFGDTKGKLKRLPVlnDDDFI-------LTINRQELSQILINEAEKYNNVKFHFNCKATKFDLKSESLIVQNSDNlSTVD 153
Cdd:PRK08163  78 MDAVDAEEVVRIPT--GQAFRarfgnpyAVIHRADIHLSLLEAVLDHPLVEFRTSTHVVGIEQDGDGVTVFDQQG-NRWT 154

                        170
                 ....*....|....*....
gi 212646493 154 GDLFLACDGAHSSIRRSLL 172
Cdd:PRK08163 155 GDALIGCDGVKSVVRQSLV 173
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 4-317 2.11e-06

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 49.76  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493    4 VVIAGGGLVGSANACFFGQ-------KGWIVD----------VYESRFDPRGNHMEngksinlALGVRAMSTMKRIGLKE 66
Cdd:TIGR01989   3 VVIVGGGPVGLALAAALGNnpltkdlKVLLLDavdnpklksrNYEKPDGPYSNRVS-------SITPASISFFKKIGAWD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   67 KVIHigvpirDQIAHFG-----DTKGK----LKRLPVLNDDDFILTINRQELSQILINEAEKYNNVKFHFNCKATKFDLK 137
Cdd:TIGR01989  76 HIQS------DRIQPFGrmqvwDGCSLalirFDRDNGKEDMACIIENDNIQNSLYNRLQEYNGDNVKILNPARLISVTIP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  138 SES---------LIVQNSDNLSTvdgDLFLACDGAHSSIRR-SLLKAPGFNFSQkYSEFGYIDLSVNSTQQCdlklgthy 207
Cdd:TIGR01989 150 SKYpndnsnwvhITLSDGQVLYT---KLLIGADGSNSNVRKaANIDTTGWNYNQ-HAVVATLKLEEATENDV-------- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  208 SWRR---RG-IILVAIVNKDQSLTVSMfatfSEFESNL---VGPVESVLFFKNNF--------------YEIFKiLGEDH 266
Cdd:TIGR01989 218 AWQRflpTGpIALLPLPDNNSTLVWST----SPEEALRllsLPPEDFVDALNAAFdlgysdhpysylldYAMEK-LNEDI 292

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212646493  267 IRNTIARNK----PQAIISVQCSQHVFF------------DKLVLMGDAAHAMVPFNGQGVNCGFED 317
Cdd:TIGR01989 293 GFRTEGSKScfqvPPRVIGVVDKSRAAFplglghadeyvtKRVALVGDAAHRVHPLAGQGVNLGFGD 359
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
4-330 5.30e-06

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 48.75  E-value: 5.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   4 VVIAGGGLVGSANACFFGQKGWIVDVYESRFD----PRGNHMENgksinlalgvRAMSTMKRIGLKEKVIHIGVPirDQI 79
Cdd:PRK06183  13 VVIVGAGPVGLTLANLLGQYGVRVLVLERWPTlydlPRAVGIDD----------EALRVLQAIGLADEVLPHTTP--NHG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  80 AHFGDTKGK-LKRLPVLNDDDF----ILTINRQELSQILINEAEKYNNVKFHFNCKATKFDLKSESLIVQNSD---NLST 151
Cdd:PRK06183  81 MRFLDAKGRcLAEIARPSTGEFgwprRNAFHQPLLEAVLRAGLARFPHVRVRFGHEVTALTQDDDGVTVTLTDadgQRET 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 152 VDGDLFLACDGAHSSIRRSL-LKAPGFNFSQKYSefgYIDLSV--------NSTQQCD-------LKLGthYSWRRRGII 215
Cdd:PRK06183 161 VRARYVVGCDGANSFVRRTLgVPFEDLTFPERWL---VVDVLIandplggpHTYQYCDparpytsVRLP--HGRRRWEFM 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 216 LV-----AIVNKDQSLTvSMFATFsefesnLVGPVESVLffknnfyeifkilgedhIRNTI----ARnkpqaIISVQCSQ 286
Cdd:PRK06183 236 LLpgeteEQLASPENVW-RLLAPW------GPTPDDAEL-----------------IRHAVytfhAR-----VADRWRSG 286

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 212646493 287 HVFfdklvLMGDAAHAMVPFNGQGVNCGFEDC--------LVLQ-----EIMDQYEE 330
Cdd:PRK06183 287 RVL-----LAGDAAHLMPPFAGQGMNSGIRDAanlawklaAVLRgragdALLDTYEQ 338
PRK06847 PRK06847
hypothetical protein; Provisional
 4-172 5.86e-06

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 48.33  E-value: 5.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   4 VVIAGGGLVGSANACFFGQKGWIVDVYESRFDPRgnhmENGKSINLaLG--VRAmstMKRIGLKEKVIHIGVPIrDQIAH 81
Cdd:PRK06847   7 VLIVGGGIGGLSAAIALRRAGIAVDLVEIDPEWR----VYGAGITL-QGnaLRA---LRELGVLDECLEAGFGF-DGVDL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  82 FgDTKG-KLKRLPV--LNDDDF--ILTINRQELSQILINEAEKyNNVKFHFNCKATKFDLKSESLIVQNSDNlSTVDGDL 156
Cdd:PRK06847  78 F-DPDGtLLAELPTprLAGDDLpgGGGIMRPALARILADAARA-AGADVRLGTTVTAIEQDDDGVTVTFSDG-TTGRYDL 154

                        170
                 ....*....|....*.
gi 212646493 157 FLACDGAHSSIRRSLL 172
Cdd:PRK06847 155 VVGADGLYSKVRSLVF 170
PRK05714 PRK05714
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 293-336 1.03e-05

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 168201 [Multi-domain]  Cd Length: 405  Bit Score: 47.52  E-value: 1.03e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 212646493 293 LVLMGDAAHAMVPFNGQGVNCGFEDCLVLQEIMDQYEE--DELEDV 336
Cdd:PRK05714 287 LALIGDAAHTIHPLAGQGVNLGFLDAAVLAEVLLHAAErgERLADV 332
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
293-330 3.18e-05

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 46.10  E-value: 3.18e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 212646493 293 LVLMGDAAHAMVPFNGQGVNCGFEDCLVLQEIMDQYEE 330
Cdd:PRK07608 282 VALVGDAAHLIHPLAGQGMNLGLRDVAALADVLAGREP 319
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 293-353 3.39e-05

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 45.74  E-value: 3.39e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212646493 293 LVLMGDAAHAMVPFNGQGVNCGFED--CL--VLQEIMDQYEEDELEDVIKEYSKVRTNEtNIINQ 353
Cdd:PRK08020 283 LALVGDAAHTINPLAGQGVNLGYRDvdALldVLVNARSYGEAWASEAVLKRYQRRRMAD-NLLMQ 346
PRK08013 PRK08013
oxidoreductase; Provisional
 292-317 6.85e-05

oxidoreductase; Provisional


Pssm-ID: 236139 [Multi-domain]  Cd Length: 400  Bit Score: 45.04  E-value: 6.85e-05
                         10        20
                 ....*....|....*....|....*.
gi 212646493 292 KLVLMGDAAHAMVPFNGQGVNCGFED 317
Cdd:PRK08013 283 RLALVGDAAHTIHPLAGQGVNLGFMD 308
PRK06185 PRK06185
FAD-dependent oxidoreductase;
291-312 1.10e-04

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 44.08  E-value: 1.10e-04
                         10        20
                 ....*....|....*....|..
gi 212646493 291 DKLVLMGDAAHAMVPFNGQGVN 312
Cdd:PRK06185 284 PGLLCIGDAAHAMSPVGGVGIN 305
PRK08773 PRK08773
UbiH/UbiF family hydroxylase;
283-327 3.11e-04

UbiH/UbiF family hydroxylase;


Pssm-ID: 181552 [Multi-domain]  Cd Length: 392  Bit Score: 42.93  E-value: 3.11e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 212646493 283 QCSQHVFFDKLVLMGDAAHAMVPFNGQGVNCGFEDCLVLQEIMDQ 327
Cdd:PRK08773 274 QLVQQYVSGRVLTLGDAAHVVHPLAGQGVNLGLRDVAALQQLVRQ 318
PRK08850 PRK08850
2-octaprenyl-6-methoxyphenol hydroxylase; Validated
 291-332 5.43e-04

2-octaprenyl-6-methoxyphenol hydroxylase; Validated


Pssm-ID: 236341 [Multi-domain]  Cd Length: 405  Bit Score: 42.07  E-value: 5.43e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 212646493 291 DKLVLMGDAAHAMVPFNGQGVNCGFEDCLVL-QEIMDQYEEDE 332
Cdd:PRK08850 282 ERVALVGDAAHTIHPLAGQGVNLGLLDAASLaQEILALWQQGR 324
PRK05868 PRK05868
FAD-binding protein;
1-169 6.03e-04

FAD-binding protein;


Pssm-ID: 180297 [Multi-domain]  Cd Length: 372  Bit Score: 41.90  E-value: 6.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   1 MPSVVIAGGGLVGSANACFFGQKGWIVDVYESRFDPRgnhmENGKSINlalgVR--AMSTMKRIGL-------KEKVIHI 71
Cdd:PRK05868   1 MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLR----PGGQAID----VRgpALDVLERMGLlaaaqehKTRIRGA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493  72 GVPIRDQIAHFGDTKGKLKRLPVLNDDDFILtinRQELSQILINEAEkyNNVKFHFNCKATKFDLKSESLIVqNSDNLST 151
Cdd:PRK05868  73 SFVDRDGNELFRDTESTPTGGPVNSPDIELL---RDDLVELLYGATQ--PSVEYLFDDSISTLQDDGDSVRV-TFERAAA 146

                        170
                 ....*....|....*...
gi 212646493 152 VDGDLFLACDGAHSSIRR 169
Cdd:PRK05868 147 REFDLVIGADGLHSNVRR 164
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
292-324 1.48e-03

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 40.73  E-value: 1.48e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 212646493 292 KLVLMGDAAHAMVPFNGQGVNCGFEDCLVLQEI 324
Cdd:PRK07333 281 RFALVGDAAHGIHPIAGQGLNLGLKDVAALAEV 313
PLN02487 PLN02487
zeta-carotene desaturase
 3-92 2.94e-03

zeta-carotene desaturase


Pssm-ID: 215268 [Multi-domain]  Cd Length: 569  Bit Score: 39.78  E-value: 2.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493   3 SVVIAGGGLVGSANACFFGQKGWIVDVYESR----------FDPRGNHMENGKSINLALGVRAMSTMKRIGLKEKVIhig 72
Cdd:PLN02487  77 KVAIIGAGLAGMSTAVELLDQGHEVDIYESRpfiggkvgsfVDKNGNHIEMGLHVFFGCYNNLFRLMKKVGADENLL--- 153

                         90       100
                 ....*....|....*....|
gi 212646493  73 vpIRDQIAHFGDTKGKLKRL 92
Cdd:PLN02487 154 --VKDHTHTFVNKGGDVGEL 171
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-64 3.11e-03

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 39.84  E-value: 3.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212646493   1 MPSVVIAGGGLVGSANACFFGQKGWIVDVYESR----------FDPR-GNHMENGksINLALG----VRAmsTMKRIGL 64
Cdd:COG3349    3 PPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARprlggrarsfPDPDtGLPIDNG--QHVLLGcyrnTLD--LLRRIGA 77
PRK07364 PRK07364
FAD-dependent hydroxylase;
291-351 3.90e-03

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 39.23  E-value: 3.90e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212646493 291 DKLVLMGDAAHAMVPFNGQGVNCGFEDCLVLQEIMD---QYEED--ELEdVIKEYSKVRTNETNII 351
Cdd:PRK07364 294 HRLALVGDAAHCCHPVGGQGLNLGIRDAAALAQVLQtahQRGEDigSLA-VLKRYERWRKRENWLI 358
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
280-367 4.53e-03

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 39.12  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646493 280 ISVQCSQHVFFDKLVLMGDAAHAMVPFNGQGVNCGFEDCLVLQEIMDQYEEDEL-EDVIKEYSKVRtnetniinqmEWDV 358
Cdd:PRK07494 269 LSGQVAHRFAAGRTALVGEAAHVFPPIGAQGLNLGLRDVATLVEIVEDRPEDPGsAAVLAAYDRAR----------RPDI 338


                 ....*....
gi 212646493 359 nLTLTSSVH 367
Cdd:PRK07494 339 -LSRTASVD 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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