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unc-80 Protein unc-80 [ Caenorhabditis elegans ]

Gene ID: 180374, updated on 9-Dec-2024

Summary

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Official Symbol
unc-80
Official Full Name
Protein unc-80
Primary source
WormBase:WBGene00006812
Locus tag
CELE_F25C8.3
See related
AllianceGenome:WB:WBGene00006812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Is expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Orthologous to human UNC80 (unc-80 homolog, NALCN channel complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-80 in Genome Data Viewer
Location:
chromosome: V
Exon count:
37
Sequence:
Chromosome: V; NC_003283.11 (20879601..20898948)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MATH domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Amine oxidase domain-containing protein Neighboring gene 4-coumarate--CoA ligase 1-like Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Food deprivation and nicotine correct akinesia and freezing in Na(+) -leak current channel (NALCN)-deficient strains of Caenorhabditis elegans. Bonnett K, et al. Genes Brain Behav, 2014 Sep. PMID 24995777
  2. The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate Caenorhabditis elegans Reversal Behavior. Zhou C, et al. G3 (Bethesda), 2020 Jan 7. PMID 31690562, Free PMC Article
  3. Structures of spontaneous deletions in Caenorhabditis elegans. Pulak RA, et al. Mol Cell Biol, 1988 Sep. PMID 3221864, Free PMC Article
  4. The effect of two genes on anesthetic response in the nematode Caenorhabditis elegans. Morgan PG, et al. Anesthesiology, 1988 Aug. PMID 2900611
  5. Genetic analysis of crawling and swimming locomotory patterns in C. elegans. Pierce-Shimomura JT, et al. Proc Natl Acad Sci U S A, 2008 Dec 30. PMID 19074276, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UNC-80 regulates C. elegans reversal behavior through command interneurons.
    Title: The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate Caenorhabditis elegans Reversal Behavior.
  2. at least in part by transmitting depolarization signals to synapses in C. elegans neurons.
    Title: A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of locomotion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to anesthetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cation channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein unc-80
NP_001023839.2
  • Confirmed by transcript evidence
NP_001023840.2
  • Confirmed by transcript evidence
NP_001129895.2
  • Confirmed by transcript evidence
NP_001256961.1
  • Confirmed by transcript evidence
NP_001256962.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20879601..20898948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028669.4 → NP_001023840.2  Protein unc-80 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023840.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XV66
    Conserved Domains (1) summary
    pfam15778
    Location:42 → 229
    UNC80; Cation channel complex component UNC80

  2. NM_001028668.4 → NP_001023839.2  Protein unc-80 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023839.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XV66
    Conserved Domains (2) summary
    TIGR03825
    Location:1845 → 2013
    FliH_bacil; flagellar assembly protein FliH
    pfam15778
    Location:42 → 229
    UNC80; Cation channel complex component UNC80

  3. NM_001270033.2 → NP_001256962.1  Protein unc-80 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256962.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XV66
    Conserved Domains (1) summary
    pfam15778
    Location:42 → 229
    UNC80; Cation channel complex component UNC80

  4. NM_001270032.3 → NP_001256961.1  Protein unc-80 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256961.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5U8P2, C1P651, H9G315, Q7JKT8, Q9XV66
    Conserved Domains (2) summary
    pfam15778
    Location:42 → 229
    UNC80; Cation channel complex component UNC80
    pfam19424
    Location:770 → 3065
    UNC80; Protein UNC80

  5. NM_001136423.4 → NP_001129895.2  Protein unc-80 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129895.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XV66
    Conserved Domains (1) summary
    pfam15778
    Location:24 → 211
    UNC80; Cation channel complex component UNC80
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XV66.4

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