Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, ...
1893-2999
0e+00
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.
The actual alignment was detected with superfamily member pfam20262:
Pssm-ID: 466412 Cd Length: 1079 Bit Score: 1035.84 E-value: 0e+00
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a ...
1079-1894
4.45e-154
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.
The actual alignment was detected with superfamily member pfam19424:
Pssm-ID: 466075 Cd Length: 704 Bit Score: 497.01 E-value: 4.45e-154
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the ...
24-211
8.75e-94
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.
:
Pssm-ID: 464864 Cd Length: 187 Bit Score: 301.97 E-value: 8.75e-94
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, ...
1893-2999
0e+00
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.
Pssm-ID: 466412 Cd Length: 1079 Bit Score: 1035.84 E-value: 0e+00
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a ...
1079-1894
4.45e-154
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.
Pssm-ID: 466075 Cd Length: 704 Bit Score: 497.01 E-value: 4.45e-154
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the ...
24-211
8.75e-94
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.
Pssm-ID: 464864 Cd Length: 187 Bit Score: 301.97 E-value: 8.75e-94
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, ...
1893-2999
0e+00
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.
Pssm-ID: 466412 Cd Length: 1079 Bit Score: 1035.84 E-value: 0e+00
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a ...
1079-1894
4.45e-154
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.
Pssm-ID: 466075 Cd Length: 704 Bit Score: 497.01 E-value: 4.45e-154
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the ...
24-211
8.75e-94
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.
Pssm-ID: 464864 Cd Length: 187 Bit Score: 301.97 E-value: 8.75e-94
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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the domain superfamily to which the specific and non-specific hits belong
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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