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scc-3 Cohesin subunit scc-3 [ Caenorhabditis elegans ]

Gene ID: 179749, updated on 4-Jan-2025

Summary

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Official Symbol
scc-3
Official Full Name
Cohesin subunit scc-3
Primary source
WormBase:WBGene00004738
Locus tag
CELE_F18E2.3
See related
AllianceGenome:WB:WBGene00004738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity and chromatin binding activity. Involved in meiotic sister chromatid cohesion; nuclear division; and regulation of DNA damage checkpoint. Located in chromatin and condensed chromosome. Part of cohesin complex. Is expressed in gonad. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked; Mullegama-Klein-Martinez syndrome; autosomal dominant intellectual developmental disorder 47; primary ovarian insufficiency 8; and spermatogenic failure 61. Orthologous to several human genes including STAG1 (STAG1 cohesin complex component) and STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See scc-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (12763945..12767933)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ABC transporter domain-containing protein Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint. Lightfoot J, et al. Curr Biol, 2011 Sep 13. PMID 21856158
  2. Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis. Wang F, et al. Mol Cell Biol, 2003 Nov. PMID 14560015, Free PMC Article
  3. Distinct developmental function of two Caenorhabditis elegans homologs of the cohesin subunit Scc1/Rad21. Mito Y, et al. Mol Biol Cell, 2003 Jun. PMID 12808038, Free PMC Article
  4. The Caenorhabditis elegans SCC-3 homologue is required for meiotic synapsis and for proper chromosome disjunction in mitosis and meiosis. Pasierbek P, et al. Exp Cell Res, 2003 Oct 1. PMID 14499625
  5. Condensin I protects meiotic cohesin from WAPL-1 mediated removal. Hernandez MR, et al. PLoS Genet, 2018 May. PMID 29768402, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that condensin I binds to WAPL-1 and counteracts WAPL-1-dependent cohesin removal.
    Title: Condensin I protects meiotic cohesin from WAPL-1 mediated removal.
  2. Cytological localization and the consequences of the lack of the protein indicate that C. elegans SCC-3 is essential for sister chromatid cohesion both in mitosis and in meiosis.
    Title: The Caenorhabditis elegans SCC-3 homologue is required for meiotic synapsis and for proper chromosome disjunction in mitosis and meiosis.
  3. These results indicate that EVL-14/PDS-5 and SCC-3 have functions in both mitosis and meiosis.
    Title: Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair involved in meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cohesin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cohesin subunit scc-3
NP_506193.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12763945..12767933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073792.6 → NP_506193.1  Cohesin subunit scc-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506193.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19555
    Conserved Domains (1) summary
    pfam08514
    Location:184 → 286
    STAG; STAG domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19555.1

Gene LinkOut

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