rga-5 Rho-GAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rga-5
Official Full Name: Rho-GAP domain-containing protein
Primary source: WormBase:WBGene00010374
Locus tag: CELE_H08M01.2
See related: AllianceGenome:WB:WBGene00010374
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in Rho protein signal transduction; regulation of axonogenesis; and regulation of cell size. Predicted to be active in cytosol. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35) and ARHGAP5 (Rho GTPase activating protein 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rga-5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 21

Sequence:: Chromosome: IV; NC_003282.8 (13827886..13844991)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H08M01.1 (e-PCR)
- UniSTS:314563

H08M01.2 (e-PCR)
- UniSTS:314564

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell size	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rho-GAP domain-containing protein

NP_001023257.1

Confirmed by transcript evidence

NP_001255759.1

Confirmed by transcript evidence

NP_001255760.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13827886..13844991

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028086.6 → NP_001023257.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023257.1

Status: REVIEWED

UniProtKB/TrEMBL

O45611

Conserved Domains (2) summary

cd00882
Location:164 → 257

Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)

cl02570
Location:1141 → 1332

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
NM_001268830.3 → NP_001255759.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255759.1

Status: REVIEWED

UniProtKB/TrEMBL

D3YT91

Conserved Domains (1) summary

cl02570
Location:333 → 524

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
NM_001268831.3 → NP_001255760.1 Rho-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255760.1

Status: REVIEWED

UniProtKB/TrEMBL

D3YT92

Conserved Domains (1) summary

cl02570
Location:24 → 215

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...