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pyk-2 Pyruvate kinase [ Caenorhabditis elegans ]

Gene ID: 177984, updated on 4-Jan-2025

Summary

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Official Symbol
pyk-2
Official Full Name
Pyruvate kinase
Primary source
WormBase:WBGene00014001
Locus tag
CELE_ZK593.1
See related
AllianceGenome:WB:WBGene00014001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable pyruvate kinase activity. Predicted to be involved in glycolytic process. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in intestine. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pyk-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (10909913..10913078)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene TransThyretin-Related family domain;Transposase Neighboring gene ncRNA Neighboring gene High-affinity choline transporter 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension. Onken B, et al. PLoS Genet, 2020 Aug. PMID 32841230, Free PMC Article
  2. Exploring transcriptional conservation between Ancylostoma caninum and Haemonchus contortus by oligonucleotide microarray and bioinformatic analyses. Cantacessi C, et al. Mol Cell Probes, 2009 Feb. PMID 18977290
  3. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
  4. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
  5. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in sarcomere HDA PubMed 
located_in striated muscle dense body HDA PubMed 

General protein information

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Preferred Names
Pyruvate kinase
NP_001255515.1
  • Confirmed by transcript evidence
NP_001255516.1
  • Confirmed by transcript evidence
NP_001255517.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10909913..10913078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268587.3 → NP_001255516.1  Pyruvate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255516.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT36
    Conserved Domains (2) summary
    cd00288
    Location:32 → 512
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:32 → 509
    pyruv_kin; pyruvate kinase

  2. NM_001268586.3 → NP_001255515.1  Pyruvate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255515.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23539
    Conserved Domains (2) summary
    cd00288
    Location:34 → 514
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:34 → 511
    pyruv_kin; pyruvate kinase

  3. NM_001268588.3 → NP_001255517.1  Pyruvate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255517.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT37
    Conserved Domains (2) summary
    cd00288
    Location:1 → 460
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:1 → 457
    pyruv_kin; pyruvate kinase
Nucleotide Protein
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