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dnc-4 Dynactin subunit 4 [ Caenorhabditis elegans ]

Gene ID: 177600, updated on 4-Jan-2025

Summary

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Official Symbol
dnc-4
Official Full Name
Dynactin subunit 4
Primary source
WormBase:WBGene00016124
Locus tag
CELE_C26B2.1
See related
AllianceGenome:WB:WBGene00016124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Part of dynactin complex. Orthologous to human DCTN4 (dynactin subunit 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dnc-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (8018175..8019808, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C3H1-type domain-containing protein Neighboring gene Cytochrome c oxidase assembly protein COX14;Cytochrome c oxidase assembly protein COX20, mitochondrial Neighboring gene Elongator complex protein 4 Neighboring gene Membrane-associated kinase regulator Neighboring gene Nuclear hormone receptor family member nhr-31 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KLP6: a newly identified kinesin that regulates the morphology and transport of mitochondria in neuronal cells. Tanaka K, et al. J Cell Sci, 2011 Jul 15. PMID 21693574
  2. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Terasawa M, et al. Genes Cells, 2010 Nov. PMID 20964796, Free PMC Article
  3. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
  4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of dynactin complex IEA
Inferred from Electronic Annotation
more info
  
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dynactin subunit 4
NP_501344.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8018175..8019808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068943.6 → NP_501344.1  Dynactin subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501344.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18194
    Conserved Domains (1) summary
    pfam05502
    Location:25 → 103
    Dynactin_p62; Dynactin p62 family
Nucleotide Protein
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