kel-3 BTB domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kel-3
Official Full Name: BTB domain-containing protein
Primary source: WormBase:WBGene00002185
Locus tag: CELE_T27E9.4
See related: AllianceGenome:WB:WBGene00002185
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and vulval muscle. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See kel-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (13464829..13471347)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

T27E9.1 (e-PCR)
- UniSTS:311044

T27E9.3 (e-PCR)
- UniSTS:311045

T27E9.4 (e-PCR)
- UniSTS:315120

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BTB domain-containing protein

NP_499784.2

Confirmed by transcript evidence

NP_499785.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13464829..13471347

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067384.7 → NP_499785.2 BTB domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499785.2

Status: REVIEWED

UniProtKB/TrEMBL

O18147

Conserved Domains (3) summary

PHA03098
Location:51 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:386 → 429

Kelch; KELCH repeat [structural motif]

cd18247
Location:32 → 147

BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
NM_067383.7 → NP_499784.2 BTB domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499784.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8WQC4

Conserved Domains (3) summary

PHA03098
Location:51 → 568

PHA03098; kelch-like protein; Provisional

sd00038
Location:388 → 431

Kelch; KELCH repeat [structural motif]

cl38908
Location:32 → 149

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily