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cccp-1 CARD domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176674, updated on 9-Dec-2024

Summary

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Official Symbol
cccp-1
Official Full Name
CARD domain-containing protein
Primary source
WormBase:WBGene00013042
Locus tag
CELE_Y49E10.23
See related
AllianceGenome:WB:WBGene00013042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables small GTPase binding activity. Involved in dense core granule maturation and regulation of locomotion involved in locomotory behavior. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in intestine; neurons; and spermatheca. Orthologous to human CCDC186 (coiled-coil domain containing 186). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cccp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (12472873..12484651)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Phosphoryl Seryl-TRNA (Ser/Sec) Kinase Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Arrestin C-terminal-like domain-containing protein Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The dense-core vesicle maturation protein CCCP-1 binds RAB-2 and membranes through its C-terminal domain. Cattin-Ortolá J, et al. Traffic, 2017 Nov. PMID 28755404, Free PMC Article
  2. Two Rab2 interactors regulate dense-core vesicle maturation. Ailion M, et al. Neuron, 2014 Apr 2. PMID 24698274, Free PMC Article
  3. Genetic analysis of defecation in Caenorhabditis elegans. Thomas JH. Genetics, 1990 Apr. PMID 2323555, Free PMC Article
  4. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
  5. Functional transcriptomics of a migrating cell in Caenorhabditis elegans. Schwarz EM, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22991463, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We conclude that CCCP-1 is a coiled-coil protein that binds an activated Rab and localizes to the Golgi via its C-terminus.
    Title: The dense-core vesicle maturation protein CCCP-1 binds RAB-2 and membranes through its C-terminal domain.
  2. This study demonistrated that cccp-1 regulate dense-core vesicle maturation.
    Title: Two Rab2 interactors regulate dense-core vesicle maturation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dense core granule maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of locomotion involved in locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle cytoskeletal trafficking IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CARD domain-containing protein
NP_499628.1
  • Confirmed by transcript evidence
NP_871700.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12472873..12484651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181971.6 → NP_871700.1  CARD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871700.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I0Z1
    Conserved Domains (1) summary
    COG1196
    Location:159 → 507
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_067227.7 → NP_499628.1  CARD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499628.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XTT2
    Conserved Domains (1) summary
    COG1196
    Location:159 → 507
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version

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