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ift-139 Tetratricopeptide repeat protein 21 homolog [ Caenorhabditis elegans ]

Gene ID: 175855, updated on 4-Jan-2025

Summary

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Official Symbol
ift-139
Official Full Name
Tetratricopeptide repeat protein 21 homolog
Primary source
WormBase:WBGene00022696
Locus tag
CELE_ZK328.7
See related
AllianceGenome:WB:WBGene00022696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in intraciliary retrograde transport and protein localization to cilium. Predicted to be located in several cellular components, including cilium; cytoskeleton; and dendrite. Predicted to be part of intraciliary transport particle A. Is expressed in neurons. Used to study nephronophthisis. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 4; nephronophthisis 12; and spermatogenic failure 37. Orthologous to human TTC21A (tetratricopeptide repeat domain 21A) and TTC21B (tetratricopeptide repeat domain 21B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ift-139 in Genome Data Viewer
Location:
chromosome: III
Exon count:
15
Sequence:
Chromosome: III; NC_003281.10 (6032563..6039470, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative F-box protein ZK328.6 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Putative T-box protein 11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans. Niwa S. Sci Rep, 2016 Aug 12. PMID 27515926, Free PMC Article
  2. Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans. Higashida M, et al. Genes Cells, 2023 Feb. PMID 36461782
  3. Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia. Yi P, et al. Curr Biol, 2017 May 22. PMID 28479320
  4. Functional genomics of the cilium, a sensory organelle. Blacque OE, et al. Curr Biol, 2005 May 24. PMID 15916950
  5. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that ift-139 is evolutionarily conserved and fundamental to the formation of cilia.
    Title: The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tetratricopeptide repeat protein 21 homolog
NP_001022993.2
  • Confirmed by transcript evidence
NP_001022994.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6032563..6039470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027822.5 → NP_001022993.2  Tetratricopeptide repeat protein 21 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022993.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20255, Q23468, Q7Z146
    Conserved Domains (2) summary
    sd00006
    Location:1206 → 1233
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:740 → 802
    TPR_11; TPR repeat

  2. NM_001027823.4 → NP_001022994.1  Tetratricopeptide repeat protein 21 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20255
    Conserved Domains (3) summary
    COG0457
    Location:618 → 784
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:707 → 732
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:740 → 802
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20255.3

Gene LinkOut

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